IMSD at Rush University

项目摘要/摘要：关于新兴科学家职业选择的国家数据表明，不到25% 在学术环境中追求一条传统的独立道路。这一严峻的现实对 代表不足的少数族裔(URM)，他们占大学适龄个人的39%，但只占生活中博士学位的13% 科学。2015年，我们获得了NIGM R25最大限度促进学生发展倡议(Rush-IMSD)。 年，Rush R25-IMSD负责在拉什大学培训生物科学博士后 伊利诺伊州芝加哥尽管Rush R25-IMSD是一个萌芽项目，但我们在 前5年培训和留住博士生，其中一些人获得了F31和/或研究 补充奖励。这个致力于URM博士培训的正式结构是Rush的第一个，在 建立联盟，在校内外推广URM教育。具体地说，Rush R25-IMSD 这是一项有据可查的成功，符合机构对多样性和包容性的承诺。 认识到少数族裔在博士生命科学项目中的代表性仍然不足，以及 因此，生物医学劳动力没有反映出我们国家的多样性，我们提出了一个新的计划 根据T32机制培训拉什大学的URM博士生(因为NIGM正在逐步淘汰R25 IMSD)。T32 IMSD-Rush的支柱是严格的指导、教育和研究培训的三合一 通过利用国家公认的导师和项目教师的专业知识来培养URM博士生 跨几个部门。每年将选出三名学生参加T32 IMSD-Rush和 为预科的前三年提供支助(另有一名参与者将得到机构支助)。 总而言之，我们预计未来五年将有20名学生。T32 IMSD-Rush的首要目标将是 通过两个相互关联的具体目标实现： 1)在以学科为基础的研究的技术和操作基础上培训新兴的URM科学家： T32 IMSD-Rush将是培养URM博士生的跨学科和多学科计划之一 学科(免疫学/微生物学、生理学和生物物理学、细胞和分子医学、神经学 科学、整形外科/生物工程)。参与者将选择一个学科，并与主要导师匹配 世卫组织将与国家公认的领导人一起从IDEA指导参与者的研究发展 成功执行的概念(例如，培训的操作阶段包括知识获取， 严格的实验设计和数据解释)。参与者还将接受高度创新和 可以跨学科使用的尖端技术，以解决有影响力的科学问题和 通过指定的成像研讨会(活细胞成像、CT扫描、共聚焦显微镜)发现，小型 动物模型(动物护理、人源化小鼠、转基因大鼠)、分子方法(RNA/DNA范围、 定量基因敲除)、定量和计算方法(高投入统计、生物信息学) 以及科学可重复性和严谨性方面的培训。参与者将被及早捕获并整合到 通过预科(暑期)培训模块进行培训。里程碑包括提交和收购 NIH个人博士后奖(F31)或个人博士后向博士后过渡奖 (F99/K00)，出版了两份同行评议的手稿，其中一份是第一作者，并成功 完成博士学位课程。 2)落实和优化培训新出现的URM科学调查员的最佳做法： 传统的导师制在很大程度上依赖于科研能力。有更大的认知度和 认识到指导应该是一种整体战略，将严谨的研究培训与 专业技能和网络/联盟建设，促进全面发展的新兴市场 科学家，他将成功地面对学术研究，特别是科学研究的挑战 将军。T32 IMSD-Rush将通过直接和定期的一对一联系提供URM指导，并 通过研讨会组织活动，最大限度地促进每个参与者的专业发展。这些 课程将包括海报和口头演示、情商、冲突等培训模块 决议、口头和非口头沟通、谈判、财务预算/财务责任 团队和/或实验室，面试技能，最重要的是建立包容的文化，作为支持性网络 对于URM。将使用最佳做法对参与者进行培训。导师/项目教职员工将接受指导 由国家研究指导网络(NRMN)建立的培训。 总的来说，这些计划是确保T32 IMSD-Rush参与者充分参与的基石 准备好应对URM科学家面临的需求和挑战。 T32 IMSD-Rush将通过一个良好集成的流程进行评估，以跟踪、报告和评估长期 受训者的任期结果。我们的调查结果将通过公开传播信息和建立网络来分享 与有类似兴趣的组织合作。我们的长期目标是在#年增加博士生的招生人数。 拉什的生物医学科学至少增加了50%，90%的人成功完成了计划，≥将有50%的人 选择研究生培训。此外，我们还设想T32 IMSD-Rush将为研究生建立模型 培训将演变为一个具有大学和社区可持续性以及持续伙伴关系的平台。

Project summary/abstract: National data on career choices of emerging scientists indicate that less than 25% pursue a traditional independent pathway in an academic environment. This grim reality is even worse for underrepresented minorities (URM), who represent 39% of college age individuals yet only 13% of PhDs in life sciences. In 2015, we were awarded a NIGM R25 Initiative for Maximizing Student Development (Rush-IMSD). Rush R25-IMSD was charged with training pre-doctoral URMs in biological sciences at Rush University in Chicago, IL. Although Rush R25-IMSD was a budding program, we achieved an impressive track record in our first 5 years of training and retaining of PhD URMs students, some of whom received F31s and/or research supplement awards. This formal structure dedicated to URM PhD training, a first at Rush, was instrumental in building alliances to promote URM education within and outside of our university. Specifically, Rush R25-IMSD is a documented success aligned with institutional commitment for diversity and inclusion. With the recognition that minorities continue to be underrepresented in PhD life science programs, and consequently the biomedical workforce does not reflect the diversity of our nation, we propose a new program for training of URM PhD students at Rush University under a T32 mechanism (as NIGM is phasing out R25 IMSDs). The pillars of T32 IMSD-Rush is a triad of rigorous mentoring, education, and research training of pre- doctoral URM students through harnessing the expertise of nationally recognized mentors and program faculty across several departments. Three students per year will be selected to participate in T32 IMSD-Rush and supported for the first three years of matriculation (an additional participant will be under institutional support). Together, we expect a cohort of 20 students over five years. The overarching goal of T32 IMSD-Rush will be attained through two interrelated specific aims: 1) Train emerging URM scientists in technical and operational basis of discipline-based research: T32 IMSD-Rush will be inter-and multidisciplinary program for training of URM PhD students in one of several disciplines (immunology/microbiology, physiology and biophysics, cell and molecular medicine, neurologic sciences, orthopedics/bioengineering). Participants will select a discipline and be matched with a primary mentor who along with nationally recognized leaders will guide the research development of the participant from idea conception to successful execution (e.g., the operational phase of training include knowledge acquisition, rigorous experimental design and data interpretation). Participants will also be trained in highly innovative and cutting-edge technology that can be used across disciplines to address impactful scientific questions and discoveries through designated workshops in imaging (live cell imaging, CT scans, confocal microscopy), small animal models (animal care, humanized mice, transgenic rats), molecular approaches (RNA/DNA scope, quantitative gene knockdown), quantitative and computational approaches (high-input statistics, bioinformatics) and training in scientific reproducibility and rigor. The participants will be captured early and integrated into the program through pre-matriculation (summer) training modules. Milestones include submission and acquisition of NIH individual predoctoral awards (F31) or individual predoctoral to postdoctoral fellow transition award (F99/K00), publication of two peer-reviewed manuscripts, one of which as a first author, and successful completion of the PhD program. 2) Implement and optimize best practices for training of emerging URM science investigators: Classical mentorship relies heavily on scientific research prowess. There is a greater recognition and appreciation that mentorship should be a holistic strategy, combining training in rigor in research with professional skills and network/alliance building to facilitate the development of a well-rounded emerging scientist, one who will successfully face the challenges of academic research, in particular, and of science in general. T32 IMSD-Rush will provide URM mentorship through direct and regular one-on-one contact and organized activities through workshops to maximize each participant’s professional development. These programs will include training modules on poster and oral presentations, emotional intelligence, conflict resolution, verbal and non-verbal communication, negotiations, financial budgeting/fiscal responsibility of running a team and/or lab, interviewing skills and most importantly building a culture of inclusion as a supportive network for URMs. Best practices will be used to train the participants. Mentors/program faculty will undergo mentorship training established by the National Research Mentoring Network (NRMN). Collectively, these initiatives are the cornerstones to ensure that T32 IMSD-Rush participants will be fully prepared to navigate the demands and challenges facing URM scientists. T32 IMSD-Rush will be evaluated through a well-integrated process to track, report, and assess long- term outcomes of trainees. Our findings will be shared through open dissemination of information and networking with organizations with similar interest. Our long-term goal is to increase enrollment of PhD URM students in biomedical sciences at Rush by at least 50%, with 90% successfully completing the program, and ≥50% will choose post-graduate training. Also, we envision that T32 IMSD-Rush instituted model for graduate student training will evolve into a platform that has university and community sustainability and sustained partnerships.