IMSD at Rush University

项目摘要/摘要：关于新兴科学家职业选择的国家数据表明， 在学术环境中追求传统的独立途径。这一严峻的现实更是雪上加霜， 代表性不足的少数民族（URM），他们占大学年龄段的39%，但只有13%的博士在生活中 以理工科为重在2015年，我们被授予NIGM R25倡议最大化学生发展（拉什IMSD）。 拉什R25-IMSD被控在拉什大学生物科学的博士前培训URMs， 伊利诺伊州芝加哥虽然Rush R25-IMSD是一个萌芽计划，但我们在我们的 前5年的培训和保留博士URMs学生，其中一些人收到F31和/或研究 追加奖励。这种正式的结构致力于URM博士培训，第一次在拉什，是在 建立联盟，以促进URM教育内外我们的大学。Rush R25-IMSD 是一个有记录的成功与机构的多元化和包容性的承诺一致。 认识到少数民族在博士生命科学项目中的代表性仍然不足， 因此，生物医学劳动力并不能反映我们国家的多样性，我们提出了一个新的计划， 在T32机制下在拉什大学培训URM博士生（因为NIGM正在逐步淘汰R25 IMSD）。T32 IMSD-Rush的支柱是严格的指导，教育和研究培训的三位一体， 博士URM学生通过利用国家认可的导师和计划教师的专业知识 在几个部门。每年将选出三名学生参加T32 IMSD-Rush， 在大学入学前三年获得支助（另一名参加者将获得机构支助）。 我们预计在五年内将有20名学生。T32 IMSD-Rush的总体目标是 通过两个相互关联的具体目标实现： 1)在基于学科的研究的技术和操作基础上培训新兴的URM科学家： T32 IMSD-Rush将是URM博士生培训的跨学科计划， 学科（免疫学/微生物学、生理学和生物物理学、细胞和分子医学、神经病学 科学、整形外科/生物工程）。参加者将选择一个学科，并与一位主要导师配对 谁沿着与国家公认的领导人将指导研究发展的参与者从想法 概念到成功执行（例如，培训操作阶段包括知识获取， 严格的实验设计和数据解释）。参与者还将接受高度创新和 尖端技术，可用于跨学科，以解决有影响力的科学问题， 通过指定的成像（活细胞成像，CT扫描，共聚焦显微镜），小 动物模型（动物护理，人源化小鼠，转基因大鼠），分子方法（RNA/DNA范围， 定量基因敲除），定量和计算方法（高投入统计学，生物信息学） 以及科学再现性和严谨性的训练。参与者将尽早被捕获并集成到 通过预科（夏季）培训模块提供课程。军事包括提交和获取 NIH个人博士前奖学金（F31）或个人博士前到博士后研究员过渡奖 (F99/K 00），出版了两篇同行评审的手稿，其中一篇是第一作者， 完成PhD课程。 2)实施和优化培训新兴URM科学调查人员的最佳实践： 传统的导师制在很大程度上依赖于科学研究能力。有一个更大的认知， 赞赏导师制应是一项整体战略，将严谨的研究培训与 专业技能和网络/联盟建设，以促进发展一个全面的新兴 科学家，一个谁将成功地面对学术研究的挑战，特别是，和科学在 将军T32 IMSD-Rush将通过直接和定期的一对一接触提供URM指导， 通过讲习班组织活动，最大限度地提高每个参与者的专业发展。这些 课程将包括海报和口头陈述，情商，冲突 决议、口头和非口头沟通、谈判、财务预算/财务责任 团队和/或实验室、面试技巧，最重要的是建立包容文化作为支持网络 对于URMs。将采用最佳做法对参与者进行培训。导师/项目教师将接受导师制 国家研究指导网络（NRMN）。 总的来说，这些举措是确保T32 IMSD-Rush参与者充分 准备好应对URM科学家面临的需求和挑战。 T32 IMSD-Rush将通过一个良好的综合过程进行评估，以跟踪、报告和评估长期 学员的长期成果。我们的研究结果将通过公开传播信息和建立网络来分享 有类似兴趣的组织。我们的长期目标是增加博士URM学生的入学率， 拉什的生物医学科学至少有50%，90%成功完成计划，≥50%将 选择研究生培训。此外，我们设想T32 IMSD-Rush为研究生制定模型 培训将发展成为一个具有大学和社区可持续性和可持续伙伴关系的平台。

Project summary/abstract: National data on career choices of emerging scientists indicate that less than 25% pursue a traditional independent pathway in an academic environment. This grim reality is even worse for underrepresented minorities (URM), who represent 39% of college age individuals yet only 13% of PhDs in life sciences. In 2015, we were awarded a NIGM R25 Initiative for Maximizing Student Development (Rush-IMSD). Rush R25-IMSD was charged with training pre-doctoral URMs in biological sciences at Rush University in Chicago, IL. Although Rush R25-IMSD was a budding program, we achieved an impressive track record in our first 5 years of training and retaining of PhD URMs students, some of whom received F31s and/or research supplement awards. This formal structure dedicated to URM PhD training, a first at Rush, was instrumental in building alliances to promote URM education within and outside of our university. Specifically, Rush R25-IMSD is a documented success aligned with institutional commitment for diversity and inclusion. With the recognition that minorities continue to be underrepresented in PhD life science programs, and consequently the biomedical workforce does not reflect the diversity of our nation, we propose a new program for training of URM PhD students at Rush University under a T32 mechanism (as NIGM is phasing out R25 IMSDs). The pillars of T32 IMSD-Rush is a triad of rigorous mentoring, education, and research training of pre- doctoral URM students through harnessing the expertise of nationally recognized mentors and program faculty across several departments. Three students per year will be selected to participate in T32 IMSD-Rush and supported for the first three years of matriculation (an additional participant will be under institutional support). Together, we expect a cohort of 20 students over five years. The overarching goal of T32 IMSD-Rush will be attained through two interrelated specific aims: 1) Train emerging URM scientists in technical and operational basis of discipline-based research: T32 IMSD-Rush will be inter-and multidisciplinary program for training of URM PhD students in one of several disciplines (immunology/microbiology, physiology and biophysics, cell and molecular medicine, neurologic sciences, orthopedics/bioengineering). Participants will select a discipline and be matched with a primary mentor who along with nationally recognized leaders will guide the research development of the participant from idea conception to successful execution (e.g., the operational phase of training include knowledge acquisition, rigorous experimental design and data interpretation). Participants will also be trained in highly innovative and cutting-edge technology that can be used across disciplines to address impactful scientific questions and discoveries through designated workshops in imaging (live cell imaging, CT scans, confocal microscopy), small animal models (animal care, humanized mice, transgenic rats), molecular approaches (RNA/DNA scope, quantitative gene knockdown), quantitative and computational approaches (high-input statistics, bioinformatics) and training in scientific reproducibility and rigor. The participants will be captured early and integrated into the program through pre-matriculation (summer) training modules. Milestones include submission and acquisition of NIH individual predoctoral awards (F31) or individual predoctoral to postdoctoral fellow transition award (F99/K00), publication of two peer-reviewed manuscripts, one of which as a first author, and successful completion of the PhD program. 2) Implement and optimize best practices for training of emerging URM science investigators: Classical mentorship relies heavily on scientific research prowess. There is a greater recognition and appreciation that mentorship should be a holistic strategy, combining training in rigor in research with professional skills and network/alliance building to facilitate the development of a well-rounded emerging scientist, one who will successfully face the challenges of academic research, in particular, and of science in general. T32 IMSD-Rush will provide URM mentorship through direct and regular one-on-one contact and organized activities through workshops to maximize each participant’s professional development. These programs will include training modules on poster and oral presentations, emotional intelligence, conflict resolution, verbal and non-verbal communication, negotiations, financial budgeting/fiscal responsibility of running a team and/or lab, interviewing skills and most importantly building a culture of inclusion as a supportive network for URMs. Best practices will be used to train the participants. Mentors/program faculty will undergo mentorship training established by the National Research Mentoring Network (NRMN). Collectively, these initiatives are the cornerstones to ensure that T32 IMSD-Rush participants will be fully prepared to navigate the demands and challenges facing URM scientists. T32 IMSD-Rush will be evaluated through a well-integrated process to track, report, and assess long- term outcomes of trainees. Our findings will be shared through open dissemination of information and networking with organizations with similar interest. Our long-term goal is to increase enrollment of PhD URM students in biomedical sciences at Rush by at least 50%, with 90% successfully completing the program, and ≥50% will choose post-graduate training. Also, we envision that T32 IMSD-Rush instituted model for graduate student training will evolve into a platform that has university and community sustainability and sustained partnerships.