A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change
饮食失调的网络信息个性化治疗与增强认知行为疗法和动态变化机制的试点研究
基本信息
- 批准号:10347759
- 负责人:
- 金额:$ 23.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-17 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAftercareAnorexia NervosaBehavior DisordersBinge EatingBinge eating disorderBody mass indexBulimiaCaringCellular PhoneCessation of lifeClinicalCognitive TherapyComplexDataDevelopmentDiagnosisDiagnosticDropoutEating DisordersEvidence based treatmentFrightGoalsGoldHeterogeneityImpairmentIndividualInterventionInvestigationJudgmentLeadLeftMental disordersMethodologyMethodsModelingOutcomeParticipantPathologyPathway AnalysisPatternPopulationPrecision therapeuticsPsychiatryPsychotherapyQuality of lifeRandomizedRecoveryResearchSpecific qualifier valueStructureSymptomsTestingTimeTranslatingUnited States National Institutes of HealthWeight GainWorkacceptability and feasibilitybaseclinical efficacycognitive enhancementcomorbidityeconomic costevidence basefeedingfollow-upimprovedindividualized medicineinnovationmobile computingmortalitynovelpersonalized medicinepreventpublic health relevanceresponsesevere mental illnesssmartphone based assessmentsocietal costsstandard caretherapy developmenttreatment optimizationtreatment planningtreatment responseuser friendly softwarevirtual
项目摘要
PROJECT SUMMARY/ABSTRACT
Eating disorders (EDs) are serious mental illness, with the second highest mortality rate of any
psychiatric disorder and carry high societal, personal, and economic costs. Treatment response
for EDs are suboptimal, with only 50% of adults responding to evidence based treatments and
no evidence-based treatment for anorexia nervosa (AN) or Other Specified Feeding or Eating
Disorder (OSFED) in existence. Part of the reason EDs are so difficult to treat is the high
heterogeneity in symptom presentation, making it difficult to identify what to target in treatment,
as two individuals, even with the same diagnosis, substantially vary. Personalized treatments for
EDs are urgently needed that can improve treatment response and minimize the suffering
associated with these illnesses. Our scientific premise, developed from our past work, is that
treatment personalized based on idiographic models (termed Network Informed Personalized
Treatment; NA-PT) will outperform the current gold-standard treatment (Enhanced Cognitive
Behavioral Therapy: CBT-E). Our study goals are to (1) develop and test the acceptability,
feasibility, and preliminary efficacy of a randomization of NA-PT versus CBT-E and (2) to test if
network-identified precision targets are the mechanism of change. These goals will ultimately
lead to the very first personalized treatment for ED and can be extended to additional
psychiatric illnesses. The proposed research uses highly innovative methods; intensive
longitudinal data collected with mobile technology is combined with state-of-the art idiographic
modeling methods to deliver a virtual, personalized treatment. Specific aims are (1) To collect
preliminary data on the feasibility and acceptability of the randomization of NA-PT (n=40) for
EDs versus CBT-E (n=40), (2) To test the initial clinical efficacy of NA-PT versus CBT-E on
clinical outcomes (e.g., ED symptoms, body mass index, quality of life) and (3) To examine if
changes in NA-identified, precision targets, as well as in dynamic network structure, are
associated with change in clinical outcomes. The proposed research has clinical impact.
Ultimately, this proposal will lead directly to the creation and dissemination of an evidence-
based personalized treatment for EDs, as well as will serve as an exemplar for personalized
treatment development across the entire field of psychiatry.
项目总结/摘要
饮食失调(ED)是严重的精神疾病,死亡率在所有疾病中排名第二。
精神疾病,并带来很高的社会,个人和经济成本。治疗反应
ED的治疗效果并不理想,只有50%的成年人对循证治疗有反应,
无神经性厌食症(AN)或其他特定喂养或进食的循证治疗
疾病(OSFED)存在。ED如此难以治疗的部分原因是
症状表现的异质性,使其难以确定治疗的目标,
因为两个人,即使有相同的诊断,也有很大的不同。个性化治疗,
紧急需要能够改善治疗反应并最大限度地减少痛苦的ED
与这些疾病有关。我们的科学前提是,从我们过去的工作中发展出来的,
基于特定模型的个性化治疗(称为网络信息个性化
治疗; NA-PT)将优于目前的金标准治疗(增强认知功能
行为疗法:CBT-E)。我们的研究目标是(1)开发和测试可接受性,
NA-PT与CBT-E随机化的可行性和初步疗效以及(2)测试是否
网络识别的精确目标是变化的机制。这些目标最终将
导致了艾德的第一个个性化治疗,并可扩展到其他
精神疾病。拟议的研究采用高度创新的方法;密集的
利用移动的技术收集的纵向数据与最先进的具体
建模方法来提供虚拟的个性化治疗。具体目标是:(1)收集
关于NA-PT(n=40)随机化的可行性和可接受性的初步数据,
EDs与CBT-E(n=40),(2)为了测试NA-PT与CBT-E在以下方面的初步临床疗效:
临床结果(例如,艾德症状、体重指数、生活质量)和(3)检查是否
对于由NA识别的精确目标,以及动态网络结构的变化,
与临床结果的变化相关。这项研究具有临床意义。
最终,这一提议将直接导致证据的产生和传播-
基于ED的个性化治疗,以及将作为个性化治疗的典范。
整个精神病学领域的治疗发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cheri Alicia Levinson其他文献
Cheri Alicia Levinson的其他文献
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{{ truncateString('Cheri Alicia Levinson', 18)}}的其他基金
Longitudinal Personalized Dynamics Among Anorexia Nervosa Symptoms, Core Dimensions, and Physiology Predicting Suicide Risk
神经性厌食症症状、核心维度和预测自杀风险的生理学之间的纵向个性化动态
- 批准号:
10731597 - 财政年份:2023
- 资助金额:
$ 23.43万 - 项目类别:
Personalized Networks and Sensor Technology Algorithms of Eating Disorder Symptoms Predicting Eating Disorder Outcomes
个性化网络和传感器技术饮食失调症状的算法预测饮食失调的结果
- 批准号:
10652078 - 财政年份:2023
- 资助金额:
$ 23.43万 - 项目类别:
Innovations in Personalizing Treatment for Eating Disorders Using Idiographic Methods and the Impact of Personalization on Psychological, Physical, and Sociodemographic Outcomes
使用具体方法对饮食失调进行个性化治疗的创新以及个性化对心理、身体和社会人口学结果的影响
- 批准号:
10685796 - 财政年份:2023
- 资助金额:
$ 23.43万 - 项目类别:
Facing Eating Disorder Fears for Anorexia Nervosa: A Virtual Relapse Prevention Program Targeted at Approach and Avoidance Behaviors
面对饮食失调对神经性厌食症的恐惧:针对接近和回避行为的虚拟复发预防计划
- 批准号:
10425019 - 财政年份:2022
- 资助金额:
$ 23.43万 - 项目类别:
Facing Eating Disorder Fears for Anorexia Nervosa: A Virtual Relapse Prevention Program Targeted at Approach and Avoidance Behaviors
面对饮食失调对神经性厌食症的恐惧:针对接近和回避行为的虚拟复发预防计划
- 批准号:
10611448 - 财政年份:2022
- 资助金额:
$ 23.43万 - 项目类别:
A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change
饮食失调的网络信息个性化治疗与增强认知行为疗法和动态变化机制的试点研究
- 批准号:
10612256 - 财政年份:2022
- 资助金额:
$ 23.43万 - 项目类别:
A Pilot Randomized Control Trial of a Relapse Prevention Online Exposure Protocol for Eating Disorders and Mechanisms of Change
针对饮食失调和变化机制的复发预防在线暴露协议的试点随机对照试验
- 批准号:
10579874 - 财政年份:2021
- 资助金额:
$ 23.43万 - 项目类别:
A Pilot Randomized Control Trial of a Relapse Prevention Online Exposure Protocol for Eating Disorders and Mechanisms of Change
针对饮食失调和变化机制的复发预防在线暴露协议的试点随机对照试验
- 批准号:
10372099 - 财政年份:2021
- 资助金额:
$ 23.43万 - 项目类别:
A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change
饮食失调的网络信息个性化治疗与增强认知行为疗法和动态变化机制的试点研究
- 批准号:
10542414 - 财政年份:2021
- 资助金额:
$ 23.43万 - 项目类别:
Diversity Supplement for 'Personalized Networks and Sensor Technology Algorithms of Eating Disorder Symptoms Predicting Eating Disorder Outcomes'
“饮食失调症状的个性化网络和传感器技术算法预测饮食失调结果”的多样性补充
- 批准号:
10329150 - 财政年份:2021
- 资助金额:
$ 23.43万 - 项目类别:
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