Administrative Core

行政构成部分 行政核心包括一个由教职员工组成的团队，他们将共同监督研究， 中心的培训、规划和外展活动。我们的多学科、机构间性质 建议不仅重视有效的科学管理，而且还创造了许多机会， 与其他组织的合作。利用这些机会是非常方便的结构， HMS系统药理学实验室（LSP），目前的提案是基于该实验室。LSP是 成立于2014年，旨在支持这里提出的系统生物学研究类型， 实验室和计算研究之间的比例约为60：40。 我们的管理计划反映了系统生物学方法的有效应用， 了解黑色素瘤、脑癌和乳腺癌的药物敏感性和耐药性的预测因素 需要研究人员的参与，这些研究人员具有跨越计算生物学、临床 科学、生物信息学、系统生物学和统计推理。行政核心将支持 这个团队的努力，并协助学生，博士后和初级教师成为未来的领导者系统 癌症生物学（目标1.1）。该核心将为参与实验性研究的不同团体的会议提供便利。 设计（目标4项目1;目标5项目2;目标6项目3）以及测量和分析方法 由系统药理学核心（目标2）执行。它还将组织一个外部咨询委员会 (Aim协调中心试点赠款（目标1.2），并开发一个网站， 中心的活动（目标1.1），并分发其成果和数据。行政核心将监测 该中心的整体科学进展，并评估该中心的科学成就， 具体项目指标（目标1.3）。最后，核心还将支持中心的外联工作 活动包括网站开发、培训和未来与访问科学家的合作（目标1.1）。 本文所述的计划将确保研究者之间的有效沟通和互动， 中心，并与NCI和其他系统生物学中心。

SUMMARY ADMINISTRATIVE COMPONENT The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center's scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.