Admin-Core-001

管理核心-001

• 批准号: 10025683
• 负责人: PETER Karl SORGER
• 金额: $ 21.19万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-08 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10025683
• 关键词: Achievement; Administrative Coordination; Administrator; Advisory Committees; Alzheimer' s disease related dementia; Area; Belief; Biocompatible Materials; Bioinformatics; Cancer Biology; Cardiology; Clinical Sciences; Collaborations; Communication; Communication Tools; Complement; Computational Biology; Computational Science; Congresses; Data; Deposition; Development; Drug resistance; Ensure; Evaluation; Evolution; Experimental Designs; Faculty; Feedback; Funding; Future; Goals; Grant; Hospitals; Immune checkpoint inhibitor; Infrastructure; Knowledge; Laboratories; Lead; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of brain; Measurement; Methodology; Methods; Modeling; Monitor; Nature; Pharmaceutical Preparations; Pharmacology; Pilot Projects; Postdoctoral Fellow; Process; Progress Reports; Reagent; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Resistance; Risk; Role; Scientist; Site; Statistical Computing; Statistical Models; Structure; Students; Support System; System; Systems Biology; Toxic effect; Training; United States National Institutes of Health; Update; Ursidae Family; Validation; Visit; Work; base; computer science; drug sensitivity; experience; experimental study; innovation; inter-institutional; malignant breast neoplasm; meetings; melanoma; multidisciplinary; operation; organizational structure; outreach; response; senior faculty; skills; small molecule; symposium; treatment response; web site; website development

The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center’s scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.

行政核心由一组教职员工组成，他们将共同监督研究， 中心的培训、规划和外展活动。我们的多学科、跨机构的性质 提案不仅重视有效的科学管理，而且还为 与其他组织的协作。利用这些机会的结构极大地促进了 HMS系统药理学实验室(LSP)，目前的提案所基于的。LSP是 成立于2014年，旨在精确支持这里提出的系统生物学研究类型，并分为 实验室和计算研究之间的比例约为60：40。 我们的管理计划反映了这样一种信念，即有效地应用系统生物学方法来 了解黑色素瘤、脑癌和乳腺癌药物敏感性和耐药性的预测因素 需要具有不同技能集的研究人员参与，包括计算生物学、临床 科学、生物信息学、系统生物学和统计推理。行政核心将支持 帮助学生、博士后和初级教师成为系统未来的领导者 癌症生物学(目标1.1)。该核心将促进参与实验的不同小组的会议 设计(目标4项目1；目标5项目2；目标6项目3)和测量和分析方法 由系统药理学核心执行(目标2)。它还将组织一个外部咨询委员会。 (AIM 1.2)，协调中心试点赠款(AIM 1.2)，并开发一个网站，以分享关于 中心的活动(目标1.1)，并分发其成果和数据。行政核心将监督 对中心的整体科学进步情况进行综合评价，并对中心的科研成果进行综合评价。 特定于项目的指标(目标1.3)。最后，核心还将支持中心在外联方面的努力 活动包括网站开发、培训和未来与来访科学家的合作(目标1.1)。 这里描述的计划将确保调查人员之间在 该中心与NCI和其他系统生物学中心合作。