Admin-Core-001
管理核心-001
基本信息
- 批准号:10025683
- 负责人:
- 金额:$ 21.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-03-08 至 2023-02-28
- 项目状态:已结题
- 来源:
- 关键词:AchievementAdministrative CoordinationAdministratorAdvisory CommitteesAlzheimer&aposs disease related dementiaAreaBeliefBiocompatible MaterialsBioinformaticsCancer BiologyCardiologyClinical SciencesCollaborationsCommunicationCommunication ToolsComplementComputational BiologyComputational ScienceCongressesDataDepositionDevelopmentDrug resistanceEnsureEvaluationEvolutionExperimental DesignsFacultyFeedbackFundingFutureGoalsGrantHospitalsImmune checkpoint inhibitorInfrastructureKnowledgeLaboratoriesLeadLeadershipLinkMalignant NeoplasmsMalignant neoplasm of brainMeasurementMethodologyMethodsModelingMonitorNaturePharmaceutical PreparationsPharmacologyPilot ProjectsPostdoctoral FellowProcessProgress ReportsReagentResearchResearch ActivityResearch PersonnelResearch Project GrantsResearch TrainingResistanceRiskRoleScientistSiteStatistical ComputingStatistical ModelsStructureStudentsSupport SystemSystemSystems BiologyToxic effectTrainingUnited States National Institutes of HealthUpdateUrsidae FamilyValidationVisitWorkbasecomputer sciencedrug sensitivityexperienceexperimental studyinnovationinter-institutionalmalignant breast neoplasmmeetingsmelanomamultidisciplinaryoperationorganizational structureoutreachresponsesenior facultyskillssmall moleculesymposiumtreatment responseweb sitewebsite development
项目摘要
The Administrative Core comprises a team of faculty and staff who will work together to oversee the research,
training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our
proposal not only places a premium on effective scientific management but also creates many opportunities for
collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the
HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was
established in 2014 to support precisely the type of systems biology research proposed here and is split
~60:40 between laboratory and computational research.
Our management plan reflects the belief that effective application of Systems Biology methods to
understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer
requires the participation of investigators with diverse skill sets spanning computational biology, clinical
science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the
efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems
biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental
design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods
executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee
(Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the
activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the
overall scientific progress of the Center and evaluate the Center’s scientific achievements using general and
project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach
activities including website development, training, and future collaborations with visiting scientists (Aim 1.1).
The plan described herein will ensure effective communication and interaction among investigators within the
Center and with the NCI and other Systems Biology Centers.
行政核心包括一个由教职员工组成的团队,他们将共同监督研究,
中心的培训、规划和外展活动。我们的多学科、机构间性质
建议不仅重视有效的科学管理,而且还创造了许多机会,
与其他组织的合作。利用这些机会是非常方便的结构,
HMS系统药理学实验室(LSP),目前的提案是基于该实验室。LSP是
成立于2014年,旨在支持这里提出的系统生物学研究类型,
实验室和计算研究之间的比例约为60:40。
我们的管理计划反映了系统生物学方法的有效应用,
了解黑色素瘤、脑癌和乳腺癌的药物敏感性和耐药性的预测因素
需要研究人员的参与,这些研究人员具有跨越计算生物学、临床
科学、生物信息学、系统生物学和统计推理。行政核心将支持
这个团队的努力,并协助学生,博士后和初级教师成为未来的领导者系统
癌症生物学(目标1.1)。该核心将为参与实验性研究的不同团体的会议提供便利。
设计(目标4项目1;目标5项目2;目标6项目3)以及测量和分析方法
由系统药理学核心(目标2)执行。它还将组织一个外部咨询委员会
(Aim协调中心试点赠款(目标1.2),并开发一个网站,
中心的活动(目标1.1),并分发其成果和数据。行政核心将监测
该中心的整体科学进展,并评估该中心的科学成就,
具体项目指标(目标1.3)。最后,核心还将支持中心的外联工作
活动包括网站开发、培训和未来与访问科学家的合作(目标1.1)。
本文所述的计划将确保研究者之间的有效沟通和互动,
中心,并与NCI和其他系统生物学中心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PETER Karl SORGER其他文献
PETER Karl SORGER的其他文献
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{{ truncateString('PETER Karl SORGER', 18)}}的其他基金
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
皮肤和血液来源的癌前图谱(PATCH 中心)
- 批准号:
10818803 - 财政年份:2023
- 资助金额:
$ 21.19万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
10405812 - 财政年份:2021
- 资助金额:
$ 21.19万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
10343835 - 财政年份:2018
- 资助金额:
$ 21.19万 - 项目类别:
Project 1: Multi-scale modeling of adaptive drug resistance in BRAF-mutant melanoma
项目 1:BRAF 突变黑色素瘤适应性耐药的多尺度建模
- 批准号:
10343839 - 财政年份:2018
- 资助金额:
$ 21.19万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
9886211 - 财政年份:2018
- 资助金额:
$ 21.19万 - 项目类别:
Pharmaco Response Signatures and Disease Mechanism
药物反应特征和疾病机制
- 批准号:
8926239 - 财政年份:2014
- 资助金额:
$ 21.19万 - 项目类别:
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