Administrative Core
行政核心
基本信息
- 批准号:10900843
- 负责人:
- 金额:$ 50.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-04 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdministratorAffectAreaAtlasesAwardBackBenchmarkingBiological AssayBiological Specimen BanksBudgetsClinicalCollectionCommunicationCommunication ToolsCompetenceComplexComputer softwareConsultationsCore FacilityCutaneousDataData AnalysesData CollectionData Coordinating CenterData Storage and RetrievalDiseaseElectronic MailEmerging TechnologiesEnsureEuropeanEvaluationFacultyFundingGoalsHematologyHomeHumanImageImaging technologyIncubatorsInfrastructureInstitutionLaboratoriesMeasuresMediationMedicalMethodsParticipantPathologistPharmacologyProcessProtocols documentationPublishingQuality ControlReagentResearchResearch PersonnelResolutionResourcesRunningScheduleScientistSoftware EngineeringSynapsesSystemTechnologyTechnology AssessmentTrainingUnited States National Institutes of HealthUniversitiesValidationWorkcohortdata analysis pipelinedata pipelinedata repositoryexperienceimprovedindexinginter-institutionalinterestmedical schoolsmeetingsmembernew technologyoperationpremalignantprogramsprospectivequality assurancesoftware developmenttechnology developmenttooltumor
项目摘要
ADMINISTRATIVE CORE – SUMMARY ABSTRACT
The Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH Center) will construct
two pre-cancer atlases (PCAs) by combining the expertise of investigators from multiple institutions in the
Longwood Medical Area (LMA), Harvard University and the Broad Institute. By leveraging the expertise and
resources of the Laboratory of Systems Pharmacology (LSP) at Harvard Medical School, where the majority of
PATCH Center operations will be co-located, the Administrative Core will ensure bi-directional exchange of
findings and resources with other PCA/HCAs and with participants in the Human Tumor Atlas Network. The
Administrative Core will be responsible for providing logistical and organizational support for Center activities,
for coordinating workflows across institutions and for interaction with the Human Tumor Atlas Network (HTAN).
Working closely with the HTAN Data Coordinating Center (HTAN-DCC) and the NCI, the Administrative Core
will ensure that data, tools and protocols are collected and shared following standards set by the HTAN
Steering Committee.
Aim 1 will establish an Executive Committee to lead the PATCH Center and its functional units
(Biospecimen, Characterization and Data Analysis) and three subcommittees: (i) a Quality Control and
Assurance (QA) Subcommittee will be responsible for implementing QA/QC processes and compliance with
SOPs (ii) a Milestone and Benchmark (MB) Subcommittee will be responsible for ensuring timely completion of
milestones and benchmarks and for addressing any problems that arise (iii) a Technology Development and
Evaluation (TD) Subcommittee will be responsible for evaluating new and emerging technologies,
troubleshooting problems with existing technologies, and working closely with other members of the HTAN on
technology assessment, improvement and integration. Pathologist Sandro Santagata will serve as quality
assurance officer and apply his experience in CLIA laboratory operations to competency and proficiency
training across the Center. Aim 2 will develop and maintain effective communication strategies within the
PATCH Center and between HTAN centers through regular meetings and using electronic communication
tools such as Slack and Trello; and will ensure timely release of Atlas data and transfer to the HTAN-DCC via
an API. Aim 3 will perform regular evaluation of overall and interim center milestones and take corrective
action when required, including communicating to the NCI any problems likely to affect overall progress in
Atlas construction and release.
管理核心-摘要
皮肤和血液来源癌前病变中心(PATCH中心)将建立
两个癌前病变图谱(PCA),结合来自多个机构的研究人员的专业知识,
朗伍德医疗区(LMA),哈佛大学和布罗德研究所。通过利用专业知识和
资源的系统药理学实验室(LSP)在哈佛医学院,其中大多数
PATCH中心的运营将位于同一地点,管理核心将确保双向交换
与其他PCA/HCA和人类肿瘤图谱网络的参与者一起研究结果和资源。的
行政核心将负责为中心活动提供后勤和组织支持,
协调各机构的工作流程,并与人类肿瘤图谱网络(HTAN)进行互动。
与HTAN数据协调中心(HTAN-DCC)和NCI密切合作,
将确保数据、工具和协议按照HTAN设定的标准收集和共享
指导委员会。
目标1将建立一个执行委员会,领导PATCH中心及其职能部门
(生物标本、表征和数据分析)和三个小组委员会:(一)质量控制和
保证(QA)小组委员会将负责实施QA/QC流程,并遵守
(ii)一个里程碑和基准小组委员会将负责确保及时完成
(iii)技术发展和
评价小组委员会将负责评价新技术和新兴技术,
解决现有技术的问题,并与HTAN的其他成员密切合作,
技术评估、改进和整合。病理学家桑德罗·斯奇拉塔将担任质量
保证官员,并将其在CLIA实验室操作中的经验应用于能力和熟练程度
在整个中心训练。目标2将制定和维持有效的沟通战略,
PATCH中心和HTAN中心之间通过定期会议和使用电子通信
工具,如Slack和Trello;并将确保及时发布Atlas数据,并通过
一个API。目标3将定期评估总体和中期中心里程碑,并采取纠正措施
必要时采取行动,包括向NCI传达可能影响整体进展的任何问题,
Atlas的构建和发布。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PETER Karl SORGER的其他文献
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{{ truncateString('PETER Karl SORGER', 18)}}的其他基金
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
皮肤和血液来源的癌前图谱(PATCH 中心)
- 批准号:
10818803 - 财政年份:2023
- 资助金额:
$ 50.3万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
10405812 - 财政年份:2021
- 资助金额:
$ 50.3万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
10343835 - 财政年份:2018
- 资助金额:
$ 50.3万 - 项目类别:
Project 1: Multi-scale modeling of adaptive drug resistance in BRAF-mutant melanoma
项目 1:BRAF 突变黑色素瘤适应性耐药的多尺度建模
- 批准号:
10343839 - 财政年份:2018
- 资助金额:
$ 50.3万 - 项目类别:
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
免疫检查点和小分子药物治疗和不良反应的系统药理学
- 批准号:
9886211 - 财政年份:2018
- 资助金额:
$ 50.3万 - 项目类别:
Pharmaco Response Signatures and Disease Mechanism
药物反应特征和疾病机制
- 批准号:
8926239 - 财政年份:2014
- 资助金额:
$ 50.3万 - 项目类别:
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