Administrative Core

行政核心

• 批准号: 10900843
• 负责人: PETER Karl SORGER
• 金额: $ 50.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900843
• 关键词: Address; Administrator; Affect; Area; Atlases; Award; Back; Benchmarking; Biological Assay; Biological Specimen Banks; Budgets; Clinical; Collection; Communication; Communication Tools; Competence; Complex; Computer software; Consultations; Core Facility; Cutaneous; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Storage and Retrieval; Disease; Electronic Mail; Emerging Technologies; Ensure; European; Evaluation; Faculty; Funding; Goals; Hematology; Home; Human; Image; Imaging technology; Incubators; Infrastructure; Institution; Laboratories; Measures; Mediation; Medical; Methods; Participant; Pathologist; Pharmacology; Process; Protocols documentation; Publishing; Quality Control; Reagent; Research; Research Personnel; Resolution; Resources; Running; Schedule; Scientist; Software Engineering; Synapses; System; Technology; Technology Assessment; Training; United States National Institutes of Health; Universities; Validation; Work; cohort; data analysis pipeline; data pipeline; data repository; experience; improved; indexing; inter-institutional; interest; medical schools; meetings; member; new technology; operation; premalignant; programs; prospective; quality assurance; software development; technology development; tool; tumor

ADMINISTRATIVE CORE – SUMMARY ABSTRACT The Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH Center) will construct two pre-cancer atlases (PCAs) by combining the expertise of investigators from multiple institutions in the Longwood Medical Area (LMA), Harvard University and the Broad Institute. By leveraging the expertise and resources of the Laboratory of Systems Pharmacology (LSP) at Harvard Medical School, where the majority of PATCH Center operations will be co-located, the Administrative Core will ensure bi-directional exchange of findings and resources with other PCA/HCAs and with participants in the Human Tumor Atlas Network. The Administrative Core will be responsible for providing logistical and organizational support for Center activities, for coordinating workflows across institutions and for interaction with the Human Tumor Atlas Network (HTAN). Working closely with the HTAN Data Coordinating Center (HTAN-DCC) and the NCI, the Administrative Core will ensure that data, tools and protocols are collected and shared following standards set by the HTAN Steering Committee. Aim 1 will establish an Executive Committee to lead the PATCH Center and its functional units (Biospecimen, Characterization and Data Analysis) and three subcommittees: (i) a Quality Control and Assurance (QA) Subcommittee will be responsible for implementing QA/QC processes and compliance with SOPs (ii) a Milestone and Benchmark (MB) Subcommittee will be responsible for ensuring timely completion of milestones and benchmarks and for addressing any problems that arise (iii) a Technology Development and Evaluation (TD) Subcommittee will be responsible for evaluating new and emerging technologies, troubleshooting problems with existing technologies, and working closely with other members of the HTAN on technology assessment, improvement and integration. Pathologist Sandro Santagata will serve as quality assurance officer and apply his experience in CLIA laboratory operations to competency and proficiency training across the Center. Aim 2 will develop and maintain effective communication strategies within the PATCH Center and between HTAN centers through regular meetings and using electronic communication tools such as Slack and Trello; and will ensure timely release of Atlas data and transfer to the HTAN-DCC via an API. Aim 3 will perform regular evaluation of overall and interim center milestones and take corrective action when required, including communicating to the NCI any problems likely to affect overall progress in Atlas construction and release.

管理核心-摘要 皮肤和血液来源癌前病变中心（PATCH中心）将建立 两个癌前病变图谱（PCA），结合来自多个机构的研究人员的专业知识， 朗伍德医疗区（LMA），哈佛大学和布罗德研究所。通过利用专业知识和 资源的系统药理学实验室（LSP）在哈佛医学院，其中大多数 PATCH中心的运营将位于同一地点，管理核心将确保双向交换 与其他PCA/HCA和人类肿瘤图谱网络的参与者一起研究结果和资源。的 行政核心将负责为中心活动提供后勤和组织支持， 协调各机构的工作流程，并与人类肿瘤图谱网络（HTAN）进行互动。 与HTAN数据协调中心（HTAN-DCC）和NCI密切合作， 将确保数据、工具和协议按照HTAN设定的标准收集和共享 指导委员会。 目标1将建立一个执行委员会，领导PATCH中心及其职能部门 （生物标本、表征和数据分析）和三个小组委员会：（一）质量控制和 保证（QA）小组委员会将负责实施QA/QC流程，并遵守 （ii）一个里程碑和基准小组委员会将负责确保及时完成 （iii）技术发展和 评价小组委员会将负责评价新技术和新兴技术， 解决现有技术的问题，并与HTAN的其他成员密切合作， 技术评估、改进和整合。病理学家桑德罗·斯奇拉塔将担任质量 保证官员，并将其在CLIA实验室操作中的经验应用于能力和熟练程度 在整个中心训练。目标2将制定和维持有效的沟通战略， PATCH中心和HTAN中心之间通过定期会议和使用电子通信 工具，如Slack和Trello;并将确保及时发布Atlas数据，并通过 一个API。目标3将定期评估总体和中期中心里程碑，并采取纠正措施 必要时采取行动，包括向NCI传达可能影响整体进展的任何问题， Atlas的构建和发布。