Administrative Core

行政核心

• 批准号: 10900843
• 负责人: PETER Karl SORGER
• 金额: $ 50.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900843
• 关键词: Address; Administrator; Affect; Area; Atlases; Award; Back; Benchmarking; Biological Assay; Biological Specimen Banks; Budgets; Clinical; Collection; Communication; Communication Tools; Competence; Complex; Computer software; Consultations; Core Facility; Cutaneous; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Storage and Retrieval; Disease; Electronic Mail; Emerging Technologies; Ensure; European; Evaluation; Faculty; Funding; Goals; Hematology; Home; Human; Image; Imaging technology; Incubators; Infrastructure; Institution; Laboratories; Measures; Mediation; Medical; Methods; Participant; Pathologist; Pharmacology; Process; Protocols documentation; Publishing; Quality Control; Reagent; Research; Research Personnel; Resolution; Resources; Running; Schedule; Scientist; Software Engineering; Synapses; System; Technology; Technology Assessment; Training; United States National Institutes of Health; Universities; Validation; Work; cohort; data analysis pipeline; data pipeline; data repository; experience; improved; indexing; inter-institutional; interest; medical schools; meetings; member; new technology; operation; premalignant; programs; prospective; quality assurance; software development; technology development; tool; tumor

ADMINISTRATIVE CORE – SUMMARY ABSTRACT The Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH Center) will construct two pre-cancer atlases (PCAs) by combining the expertise of investigators from multiple institutions in the Longwood Medical Area (LMA), Harvard University and the Broad Institute. By leveraging the expertise and resources of the Laboratory of Systems Pharmacology (LSP) at Harvard Medical School, where the majority of PATCH Center operations will be co-located, the Administrative Core will ensure bi-directional exchange of findings and resources with other PCA/HCAs and with participants in the Human Tumor Atlas Network. The Administrative Core will be responsible for providing logistical and organizational support for Center activities, for coordinating workflows across institutions and for interaction with the Human Tumor Atlas Network (HTAN). Working closely with the HTAN Data Coordinating Center (HTAN-DCC) and the NCI, the Administrative Core will ensure that data, tools and protocols are collected and shared following standards set by the HTAN Steering Committee. Aim 1 will establish an Executive Committee to lead the PATCH Center and its functional units (Biospecimen, Characterization and Data Analysis) and three subcommittees: (i) a Quality Control and Assurance (QA) Subcommittee will be responsible for implementing QA/QC processes and compliance with SOPs (ii) a Milestone and Benchmark (MB) Subcommittee will be responsible for ensuring timely completion of milestones and benchmarks and for addressing any problems that arise (iii) a Technology Development and Evaluation (TD) Subcommittee will be responsible for evaluating new and emerging technologies, troubleshooting problems with existing technologies, and working closely with other members of the HTAN on technology assessment, improvement and integration. Pathologist Sandro Santagata will serve as quality assurance officer and apply his experience in CLIA laboratory operations to competency and proficiency training across the Center. Aim 2 will develop and maintain effective communication strategies within the PATCH Center and between HTAN centers through regular meetings and using electronic communication tools such as Slack and Trello; and will ensure timely release of Atlas data and transfer to the HTAN-DCC via an API. Aim 3 will perform regular evaluation of overall and interim center milestones and take corrective action when required, including communicating to the NCI any problems likely to affect overall progress in Atlas construction and release.

行政核心——摘要摘要 皮肤和血液起源癌前图谱中心（PATCH中心）将建设 两个癌前图谱 (PCA)，结合了来自多个机构的研究人员的专业知识 朗伍德医学区 (LMA)、哈佛大学和布罗德研究所。通过利用专业知识和 哈佛医学院系统药理学实验室 (LSP) 的资源，其中大多数 PATCH 中心运营将位于同一地点，管理核心将确保双向交换 与其他 PCA/HCA 以及人类肿瘤图谱网络参与者的研究结果和资源。这 行政核心将负责为中心活动提供后勤和组织支持， 用于协调跨机构的工作流程以及与人类肿瘤图谱网络 (HTAN) 的交互。 与 HTAN 数据协调中心 (HTAN-DCC) 和管理核心 NCI 密切合作 将确保按照 HTAN 制定的标准收集和共享数据、工具和协议 指导委员会。 目标1将成立执行委员会来领导PATCH中心及其职能单位 （生物样本、表征和数据分析）和三个小组委员会：(i) 质量控制和 保证 (QA) 小组委员会将负责实施 QA/QC 流程并遵守 SOP (ii) 里程碑和基准 (MB) 小组委员会将负责确保及时完成 里程碑和基准以及解决出现的任何问题 (iii) 技术开发和 评估（TD）小组委员会将负责评估新兴技术， 使用现有技术解决问题，并与 HTAN 的其他成员密切合作 技术评估、改进和集成。病理学家桑德罗·桑塔加塔 (Sandro Santagata) 将担任质量 保证官并将其在 CLIA 实验室运营方面的经验应用于能力和熟练程度 整个中心的培训。目标 2 将在范围内制定并维持有效的沟通策略 PATCH 中心和 HTAN 中心之间通过定期会议并使用电子通信 Slack 和 Trello 等工具；并将确保及时发布 Atlas 数据并通过以下方式传输至 HTAN-DCC： 一个 API。目标 3 将定期评估总体和中期中心里程碑并采取纠正措施 必要时采取行动，包括向 NCI 传达任何可能影响总体进展的问题 Atlas 构建和发布。