Administrative Core

行政核心由一组教职员工组成，他们将共同监督中心的研究、培训、规划和外展活动。我们的提议具有多学科、跨机构的性质，不仅强调了有效的科学管理，而且还创造了许多与其他组织合作的机会。HMS系统药理学实验室（LSP）的结构极大地促进了这些机会的开发，目前的提案正是基于此。LSP成立于2014年，以支持这里提出的系统生物学研究类型，实验室和计算研究之间的比例为60:40。我们的管理计划反映了这样一种信念，即有效地应用系统生物学方法来理解黑色素瘤、脑癌和乳腺癌的药物敏感性和耐药性预测因素，需要具有计算生物学、临床科学、生物信息学、系统生物学和统计推理等不同技能的研究人员的参与。行政核心将支持该团队的努力，并协助学生，博士后和初级教师成为癌症系统生物学的未来领导者（Aim 1.1）。核心将促进参与实验设计（Aim 4项目1；Aim 5项目2；Aim 6项目3）和系统药理学核心（Aim 2）执行的测量和分析方法的不同小组的会议。它还将组织一个外部咨询委员会（目标1.2），协调中心试点赠款（目标1.2），并开发一个网站，以分享有关中心活动的信息（目标1.1）并分发其结果和数据。行政核心将监测中心的整体科学进展，并使用一般和特定项目的指标评估中心的科学成就（目标1.3）。最后，核心还将支持中心的外联活动，包括网站开发、培训以及未来与访问科学家的合作（目标1.1）。本文所述的计划将确保研究人员在中心内部以及与NCI和其他系统生物学中心之间的有效沟通和互动。

SUMMARY ADMINISTRATIVE COMPONENT The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center's scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.