Administrative Core

行政核心

• 批准号: 10494414
• 负责人: PETER Karl SORGER
• 金额: $ 25.35万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10494414
• 关键词: Administrative; Core

SUMMARY ADMINISTRATIVE COMPONENT The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach activities of the Center. The multidisciplinary, inter-institutional nature of our proposal not only places a premium on effective scientific management but also creates many opportunities for collaboration with other organizations. Exploiting these opportunities is greatly facilitated by the structure of the HMS Laboratory of Systems Pharmacology (LSP), in which the current proposal is based. The LSP was established in 2014 to support precisely the type of systems biology research proposed here and is split ~60:40 between laboratory and computational research. Our management plan reflects the belief that effective application of Systems Biology methods to understanding predictors of drug sensitivity and resistance in melanoma, brain cancer and breast cancer requires the participation of investigators with diverse skill sets spanning computational biology, clinical science, bioinformatics, systems biology, and statistical reasoning. The Administrative Core will support the efforts of this team and assist students, postdocs and junior faculty in becoming future leaders in the systems biology of cancer (Aim 1.1). The core will facilitate meetings of the different groups involved in experimental design (Aim 4 Project 1; Aim 5 Project 2; Aim 6 Project 3) and measurement and analysis methods executed by the Systems Pharmacology Core (Aim 2). It will also organize an External Advisory Committee (Aim 1.2), coordinate Center Pilot grants (Aim 1.2) and develop a Website to share information on the activities of the Center (Aim 1.1) and to distribute its results and data. The administrative core will monitor the overall scientific progress of the Center and evaluate the Center's scientific achievements using general and project-specific metrics (Aim 1.3). Finally, the Core will also support the efforts of the Center in outreach activities including website development, training, and future collaborations with visiting scientists (Aim 1.1). The plan described herein will ensure effective communication and interaction among investigators within the Center and with the NCI and other Systems Biology Centers.

摘要行政组成的行政核心包括一个由教职员工组成的团队，他们将共同负责监督该中心的研究，培训，计划和外展活动。我们的提案的多学科，机构间的性质不仅对有效的科学管理造成了溢价，而且还为与其他组织的合作创造了许多机会。 HMS Systems药理学实验室（LSP）的结构极大地促进了这些机会。 LSP成立于2014年，目的是确切支持此处提出的系统生物学研究类型，并在实验室和计算研究之间进行了〜60：40。我们的管理计划反映了这样一种信念，即系统生物学方法在理解黑色素瘤，脑癌和乳腺癌中的药物敏感性和耐药性的预测因素上，需要参与具有计算生物学，临床科学，生物信息学，系统生物学和统计推理的各种技能的研究者。行政核心将支持该团队的努力，并协助学生，博士后和初级教师成为癌症系统生物学的未来领导者（AIM 1.1）。核心将促进参与实验设计的不同小组的会议（AIM 4项目1； AIM 5项目2； AIM 6项目3）以及系统药理学核心执行的测量和分析方法（AIM 2）。它还将组织一个外部咨询委员会（AIM 1.2），协调中心飞行员赠款（AIM 1.2），并开发一个网站，以共享有关中心活动的信息（AIM 1.1）并分发其结果和数据。行政核心将使用一般和特定项目的指标（AIM 1.3）来监视该中心的整体科学进步，并评估中心的科学成就。最后，核心还将支持该中心在外展活动中的努力，包括网站开发，培训以及与访问科学家的未来合作（AIM 1.1）。本文描述的计划将确保中心内以及NCI和其他系统生物学中心之间的有效沟通和互动。