Functional Microbiomics, Inflammation and Pathogenicity

在过去的几十年里，微生物学和免疫学领域经历了复兴，推动了 部分原因是技术进步塑造了我们对微生物作为复合体的组成部分的理解， 多菌、互动的社区。这种微生物群可以在许多基本方面发挥作用 人类的健康和疾病，在许多情况下是通过与宿主的接口产生天然免疫的。免疫者 系统的功能是限制微生物群造成的潜在损害，同时最大限度地减少 破坏性炎症反应。破坏炎症的强度、持续时间或物理位置， 然而，它可能会导致疾病。我们对微生物组的理解的进展以及一个认识 炎症过程是许多常见疾病的核心，这就需要跨学科的 在TOTO中适应宿主-微生物相互作用的视角。这个科布雷的主要目标是 建立一个专题多学科研究中心，研究微生物群之间的界面， 炎症和致病性。我们已经组建了一支初级调查员团队， 专业知识和突出的潜力，并与这些项目负责人合作，拥有高素质和敬业的 导师。一套完整的互补项目将在炎症性疾病之间建立新的联系 过程和细菌致病性，并为开发新的治疗方法和 投递方式。我们将在研究、教育、指导和职业方面创建一个多学科的项目 促进和加速初级教员向独立的校外资助的过渡 状态。研究将得到一个功能微生物核心的支持，该核心将提供无菌动物设施， 厌氧培养能力，微生物组测序和生物信息学，炎症标记物的分析，以及 病理服务。一个行政核心将协调各项活动，并提供额外的生物统计学和 生物成像支持，以及一个试点项目计划，以确保调查人员的渠道。体制性 承诺还将有助于确保主题研究计划的长期可持续性。

In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances which have shaped our understanding of microbes as components of complex, polymicrobial, interactive communities. This microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances through the interface with host innate immunity. The immune system functions to restrict the potential for damage caused by the microbiota while simultaneously minimizing destructive inflammatory responses. Disruption of the intensity, duration or physical location of inflammation, however, can contribute to disease. Advances in our understanding of the microbiome, along with a realization that inflammatory processes are at the core of a number of common diseases, necessitates a cross-disciplinary perspective that accommodates the host-microbe interaction in toto. The major goal of this COBRE is to establish a thematic multidisciplinary research center for the study of the interface between the microbiome, inflammation and pathogenicity. We have assembled a team of junior investigators with complementary expertise and outstanding potential, and have partnered these project leaders with well-qualified and dedicated mentors. An integrated set of complementary projects will make novel connections between inflammatory processes and bacterial pathogenicity, and establish the basis for the development of novel therapeutics and delivery methods. We will create a multidisciplinary program in research, education, mentoring and career development that will facilitate and accelerate the transition of junior faculty to independent extramural funded status. Research will be support by a Functional Microbiomics Core that will provide germ free animal facilities, anaerobic culture capability, microbiome sequencing and bioinformatics, assay of inflammatory markers, and pathology services. An Administrative Core will co-ordinate activities and provide additional biostatistical and bioimaging support, along with a Pilot Project program to ensure a pipeline of investigators. Institutional commitment will also help ensure long term sustainability of the thematic research program.