Functional Microbiomics, Inflammation and Pathogenicity

功能微生物组学、炎症和致病性

• 批准号: 10492096
• 负责人: Richard J Lamont
• 金额: $ 234.75万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492096
• 关键词: Acceleration; Autoimmune Diseases; Basic Science; Bioinformatics; Biological Assay; Biometry; Career Mobility; Centers of Research Excellence; Chronic; Communities; Complex; Dedications; Development; Disease; Ensure; Environment; Environmental Risk Factor; Evaluation; Extramural Activities; Faculty; Funding; Germ-Free; Goals; Health; Health Transition; Homeostasis; Human; Human Microbiome; Human body; Immune response; Immune system; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Inflammatory Response; Infrastructure; Institution; Interdisciplinary Study; International; Location; Mentors; Methods; Microbiology; Mucous Membrane; Natural Immunity; Outcomes Research; Pathogenicity; Pathway interactions; Phase; Pilot Projects; Postdoctoral Fellow; Process; Qualifying; Regulation; Renaissance; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Site; Specificity; Structure; System; Talents; Technology; Therapeutic Agents; Tissues; Training; Universities; animal facility; career; career development; design; experience; graduate student; host-microbe interactions; imaging capabilities; immune system function; inflammatory marker; innovation; interdisciplinary approach; intravital microscopy; microbial; microbial community; microbiome; microbiome research; microbiome sequencing; microbiota; multidisciplinary; novel; novel therapeutics; pathogen; programs; recruit; research and development; response; senior faculty; success; synergism; whole animal imaging

Project Summary/Abstract In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances establishing that the human microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances through the interface with host innate immunity. The immune system functions to restrict the potential for damage caused by the microbiota while simultaneously minimizing destructive inflammatory responses. Disruption of the intensity, duration or physical location of inflammation, however, can contribute to disease. Advances in our understanding of the microbiome, and its regulation by environmental factors, along with a realization that inflammatory processes are at the core of a number of common diseases, necessitates a cross-disciplinary perspective that accommodates the host- microbe interaction in toto. The major goal of this Phase 2 Cobre is to continue to develop and expand our thematic multidisciplinary research center for the study of the interface between the microbiome, inflammation and pathogenicity within a framework to develop the careers of junior investigators. We have assembled a team of junior investigators with complementary expertise and outstanding potential, and have partnered these project leaders with well-qualified and dedicated mentors. An integrated set of projects will make novel connections between inflammatory processes and bacterial pathogenicity, and establish the basis for the development of novel therapeutics and delivery methods. We will create a multidisciplinary program in research, training, mentoring and career development that will facilitate and accelerate the transition of junior faculty to independent extramural funded status. Research will be support by a Functional Microbiomics Core that will provide germ free animal facilities, anaerobic culture capability, microbiome sequencing and bioinformatics, assay of inflammatory markers, along with whole animal imaging and intravital microscopy. An Administrative Core will co-ordinate activities and provide additional biostatistical support, along with a Pilot Project program to ensure a pipeline of investigators. Institutional commitment through a university funded Center will ensure sustainability of the thematic research program.

项目总结/文摘