Inflammation and Pathogenesis Training Program

炎症与发病机制培训计划

• 批准号: 10438562
• 负责人: Richard J Lamont
• 金额: $ 15.28万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438562
• 关键词: Inflammation; Pathogenesis; Training Programs

Abstract The major objective of this new training program is to produce skilled, rigorous, and creative scientists who will make novel connections between inflammatory processes and human pathogenesis. The University of Louisville is well-positioned to have high impact by selecting trainees with leadership potential from its existing Integrated Programs in Biomedical Sciences (IPIBS) for continued training on research topics that bridge microbiology and immunology. This interdisciplinary approach will bring together 35 faculty who are all highly productive scientists with extensive mentoring experience, and well-funded research programs, focused on i) inflammatory ontogeny and immune surveillance of cancer, ii) mechanisms of autoimmune disorders, iii) cellular and molecular mechanisms of host-microbial interactions, iv) animal models of infectious disease, v) the role of the microbiota in regulation of inflammatory diseases, vi) polymicrobial communities and inflammation, and vii) inflammation-driven disease and its impact on host physiology. Pre-candidacy support from IPIBS, in which all students receive stipends and benefits funded by the University of Louisville, includes laboratory rotations, advanced didactic training in immunology; inflammation; microbiology; and pathogenesis. Pre-candidacy training also includes research survival skills, including grant development and composition, oral presentations, scientific writing and publishing, professional networking, along with extensive training in the responsible conduct of research. To attain the highest positive peer-to-peer impact, each year two students who have demonstrated exceptional performance while successfully completing their first two years of graduate education as IPIBS Fellows, will be selected for two years of support from the T32 training grant. Students from diverse backgrounds who show the most potential, based on their achievements as IPIBS Fellows in graduate coursework, a qualifying exam, and in their research projects, will be selected in order to foster their academic leadership skills and excellence as research scientists. This additional training will occur through student organization of a program-specific discussion club, hosting two high profile speakers per year in disciplines that highlight important relationships between inflammation and pathogenesis and rigorous review of their research progress by a training mentor and dissertation committee. The program will be overseen by two Directors working closely with a Steering Committee, including an independent evaluation of the training program’s organization, leadership, objectives and outcomes by Internal and External Advisory Committees.

摘要 这个新的培训计划的主要目标是培养熟练，严谨和创造性的科学家，他们将 在炎症过程和人类发病机制之间建立新的联系。大学 路易斯维尔是有利的地位，有很高的影响力，选择学员的领导潜力，从其现有的 生物医学科学综合课程（IPIBS），用于研究主题的继续培训， 微生物学和免疫学。这种跨学科的方法将汇集35名教师谁都是高度 富有成效的科学家，具有丰富的指导经验和资金充足的研究项目，重点是i） 炎性个体发生和癌症的免疫监视，ii）自身免疫性疾病的机制，iii） 宿主-微生物相互作用的细胞和分子机制，iv）感染性疾病的动物模型，v） 微生物群在调节炎性疾病中的作用，vi）多种微生物群落，以及 炎症，和vii）炎症驱动的疾病及其对宿主生理学的影响。候选人提名前的支持 从IPIBS，其中所有学生获得由路易斯维尔大学资助的津贴和福利，包括 实验室轮换，免疫学、炎症、微生物学和发病机制方面的高级教学培训。 候选人资格前培训还包括研究生存技能，包括赠款开发和组成， 口头报告，科学写作和出版，专业网络，沿着广泛的培训， 负责任地进行研究。为了达到最高的积极的对等影响，每年两名学生 他们在成功完成前两年的课程时表现出色， 作为IPIBS研究员的研究生教育，将被选为T32培训补助金的两年支持。 来自不同背景的学生谁表现出最大的潜力，根据他们的成就作为IPIBS 研究生课程，资格考试和研究项目的研究员将被选中，以便 培养他们的学术领导能力和卓越的研究科学家。这种额外的培训将在 通过学生组织的特定程序的讨论俱乐部，每年举办两个高知名度的发言人 在强调炎症和发病机制之间重要关系的学科中， 由培训导师和论文委员会审查他们的研究进展。该计划将 由两名主任与指导委员会密切合作进行监督，包括对 培训计划的组织、领导、目标和成果由内部和外部咨询 委员会。