COBRE-Administrative Core

路易斯维尔大学（UofL）COBRE在功能微生物，炎症和致病性 包括一个多学科的研究小组，研究微生物组，炎症， 和致病性研究。UofL是唯一准备调查这些问题，在一个协调和 COBRE与UofL资助的许多倡议和赠款横向整合 在相关领域的应用。口腔免疫学和传染病，微生物学和 免疫学和生物工程都有助于该中心的跨学科性质。这些单位 建立了联邦资金，指导初级教师，研究生培训和合作的记录 校园内的互动。这个应用程序是由合格和资金充足的中心主任领导。有 五名杰出的PI学员，拥有资深、成熟、受资助的辅导团队。我们提议的眼镜蛇 对整个UofL的研究产生重大的积极影响，并将有助于招聘和留住教师。无菌 即将建立的动物设施将是该国为数不多的几个动物设施之一。许多项目针对慢性 炎症性疾病在少数民族社区的发病率过高。其他项目 涉及鼠疫和类鼻疽病具有国家和国际意义。行政核心将 提供全面的管理，并确保COBRE项目和核心在一个有凝聚力的， 协调的方式。所有项目和核心都将使用行政核心。具体目标是：提供 一个正式的治理结构，以便协调、指导和确定各项活动的优先次序，包括预算 问题，确保所有职能的质量;评估进展情况;解决出现的任何冲突; 指导初级教师的正式流程;提供一种机制，在学员成为 独立;提供一个机制，以取代任何可能离开的关键个人;为以下方面提供试点资金： 初级教师，以确保调查人员的管道;提供生物统计和生物成像支持;以及 传播COBRE活动产生的相关信息。

The University of Louisville (UofL) COBRE in Functional Microbiomics, Inflammation and Pathogenicity comprises a multidisciplinary group of investigators addressing thematic aspects of microbiome, inflammation and pathogenicity studies. The UofL is uniquely poised to investigate these problems in a coordinated and efficient fashion, and the COBRE is horizontally integrated with a number of UofL funded initiatives and grant applications in related areas. The departments of Oral Immunology and Infectious Diseases, Microbiology and Immunology, and Bioengineering all contribute to the cross-disciplinary nature of the center. These units have established records of federal funding, mentoring junior faculty, graduate student training, and collaborative interactions across campus. This application is led by well-qualified and well-funded Center Directors. There are five outstanding PI-mentees with senior, established, funded mentoring teams. Our proposed COBRE will have a major positive impact on research throughout UofL, and will help recruit and retain faculty. The germ free animal facility to be established will be one of only a few in the country. Many of the projects address chronic inflammatory diseases that occur at disproportionately high incidence in minority communities. Other projects involving plague and melioidosis have national and international significance. The Administrative Core will provide overall governance and will ensure that the COBRE projects and cores work together in a cohesive and coordinated manner. All projects and cores will utilize the Administrative Core. The Specific Aims are: to provide a formal governance structure to allow coordination, direction and prioritization of activities, including budget issues, ensuring the quality of all functions; to evaluate progress; to resolve any conflicts as they arise; to provide a formalized process for mentoring junior faculty; to provide a mechanism to replace mentees as they become independent; to provide a mechanism to replace any key individuals who may leave; to provide pilot funding for junior faculty to ensure a pipeline of investigators; to provide biostatistical and bioimaging support; and to disseminate pertinent information resulting from the COBRE activities.