FMIP COBRE Administrative Core

项目摘要/摘要 路易斯维尔大学(UOL)科布雷功能微生物学、炎症和致病性(FMIP) 包括一个多学科的调查小组，处理跨越人类的主题方面 微生物组、宿主炎症反应和疾病结果。行政核心的目的是 为第二阶段的行政、财政和科学监督提供正式的治理结构 科布雷。继第一阶段的成功之后，我们处于有利地位，可以过渡到第二阶段并保持 协调高效的行政管理体制。口腔免疫科和感染科 疾病(OIID)和微生物学和免疫学(M&I)是跨学科的主要贡献者 该计划的性质。这些单位已经建立了联邦资助的记录，指导初级教员， 研究生培训以及校园内的协作互动。我们将继续相互支持 与国立卫生研究院资助的UOL其他项目的横向互动，包括肝脏生物学和毒理学 Cobre和KY-INBRE，这将提高UOL的整体研究形象。眼镜蛇的活动 将有助于招聘、留住教师并使其多样化。申请由资质良好、资金充裕的中心牵头 董事们。治理和评价由一个内部咨询委员会(IAC)和一个外部 由研究专题领域的五名国际专家组成的咨询委员会。确实有 三位杰出的研究项目负责人(RPL)，拥有资深的、成熟的、有资金支持的指导团队， 在初级教员的职业发展到独立资助地位和进一步职业生涯方面的记录 发展。我们已经制定了全面的指导和职业发展计划，包括里程碑和 评估指标。同样，Mentors和Cobre项目也是以形成性和终结性的方式进行评估。我们 有来自UOL的强有力的支持承诺，这将确保NIH资助之外的可持续性 句号。具体目标是：提供正式的治理结构，允许协调、指导 确定所有活动的优先次序，包括预算问题，从而确保所有职能的质量和增长 研究目标：管理初级教员的指导和职业发展进程，并加快 向独立的过渡；东非共同体和东非共同体协调科布雷的评价进程； 预算管理，包括预算对账以及编制和提交报告和财务报告；第#号决议 在出现任何冲突时对其进行管理；管理机制，以便在RPL独立时替换它们 必要时更换其他关键人员；管理试点计划以帮助维护管道 研究人员；协调机构支持；支持临床、翻译和商业化 研究项目的潜力；提供生物统计学支持；传播相关信息 防止科布雷活动；并确保遵守所有相关法规和准则。所有项目 核心将利用管理核心。

Project Summary/Abstract The University of Louisville (UoL) COBRE in Functional Microbiomics, Inflammation and Pathogenicity (FMIP) comprises a multidisciplinary group of investigators addressing thematic aspects that span the human microbiome, host inflammatory responses and disease outcomes. The purpose of the Administrative Core is to provide a formal governance structure for the administrative, fiscal and scientific oversight of this Phase 2 COBRE. Following on from the success of Phase 1, we are well-positioned to transition to Phase 2 and maintain a coordinated and efficient administrative structure. The departments of Oral Immunology and Infectious Diseases (OIID), and Microbiology and Immunology (M&I), are the main contributors to the cross-disciplinary nature of the program. These units have established records of federal funding, mentoring junior faculty, graduate student training, and collaborative interactions across campus. We will continue mutually supportive horizontal interactions with other NIH-funded programs at UoL including the Hepatobiology and Toxicology COBRE, and the KY-INBRE, which will enhance the overall research profile of UoL. The activities of the COBRE will help recruit, retain and diversify the faculty. The application is led by well-qualified and well-funded Center Directors. Governance and evaluation are supported by an Internal Advisory Committee (IAC), and an External Advisory Committee (EAC) comprised of five international experts in the thematic area of research. There are three outstanding Research Project Leaders (RPLs) with senior, established, funded mentoring teams with a track record in developing the careers of junior faculty through to independent funding status and further career devlopment. We have developed comprehensive mentoring and career development plans with milestones and evaluative metrics. Similarly, mentors and the COBRE program are evaluated formatively and summatively. We have a strong commitment of support from the UoL which will ensure sustainability beyond the NIH-funded period. The Specific Aims are: to provide the formal governance structure which allows coordination, direction and prioritization of all activities, including budget issues, thus ensuring the quality of all functions and growth of research goals; to administer the process for mentoring and career development of junior faculty and accelerate their transition to independence; coordination of the evaluative processes of the COBRE by the IAC and EAC; budget management including budget reconciliation, and preparing and submitting RPPRs and FFRs; resolution of any conflicts as they arise; management of mechanisms to replace RPLs as they become independent and replacement other key personnel as necessary; administration of the Pilot Program to help maintain a pipeline of investigators; coordination of institutional support; support of clinical, translational and commercialization potential of research projects; provision of biostatistical support; to disseminate pertinent information resulting from the COBRE activities; and ensuring compliance with all relevant regulations and guidelines. All projects and cores will utilize the Administrative Core.