FMIP COBRE Administrative Core

项目总结/摘要 路易斯维尔大学（UoL）COBRE在功能微生物，炎症和致病性（FMIP） 包括一个多学科的调查小组，处理跨越人类的专题方面， 微生物组、宿主炎症反应和疾病结果。行政核心的目的是 为第二阶段的行政、财政和科学监督提供正式的治理结构 眼镜蛇继第一阶段的成功之后，我们已经做好了向第二阶段过渡的准备， 一个协调和有效的行政结构。口腔免疫科和感染科 疾病（OIID）和微生物学和免疫学（M&I）是跨学科的主要贡献者。 方案的性质。这些单位已经建立了联邦资助，指导初级教师， 研究生培训和校园内的协作互动。我们将继续相互支持 与UoL其他NIH资助项目的横向互动，包括肝脏生物学和毒理学 COBRE和KY-INBRE，这将提高UoL的整体研究概况。COBRE的活动 将有助于招聘、留住和多样化教师。该应用程序是由资格和资金充足的中心领导 董事们。治理和评价由内部咨询委员会和外部咨询委员会提供支持。 咨询委员会由专题研究领域的五名国际专家组成。有 三名杰出的研究项目负责人（RPL），拥有资深的、成熟的、受资助的指导团队， 在发展初级教师的职业生涯，通过独立的资金地位和进一步的职业生涯的跟踪记录 发展。我们制定了全面的指导和职业发展计划，其中包括里程碑， 评价指标。同样，导师和COBRE计划的评价形成和总结。我们 有来自UoL的支持的坚定承诺，这将确保可持续性超出NIH资助的 期具体目标是：提供正式的治理结构， 包括预算问题，从而确保所有职能的质量和 研究目标;管理初级教师的指导和职业发展过程，并加快 过渡到独立;由临时行政理事会和东非共同体协调委员会的评价进程; 预算管理，包括预算调节，以及编制和提交RPPR和FFRs;决议 管理取代独立的保护区地雷的机制， 必要时更换其他关键人员;管理试点计划，以帮助维护管道 研究者;协调机构支持;支持临床、转化和商业化 研究项目的潜力;提供生物统计支持;传播相关信息， 从COBRE的活动;并确保遵守所有相关的法规和指导方针。所有项目 核心将使用管理核心。

Project Summary/Abstract The University of Louisville (UoL) COBRE in Functional Microbiomics, Inflammation and Pathogenicity (FMIP) comprises a multidisciplinary group of investigators addressing thematic aspects that span the human microbiome, host inflammatory responses and disease outcomes. The purpose of the Administrative Core is to provide a formal governance structure for the administrative, fiscal and scientific oversight of this Phase 2 COBRE. Following on from the success of Phase 1, we are well-positioned to transition to Phase 2 and maintain a coordinated and efficient administrative structure. The departments of Oral Immunology and Infectious Diseases (OIID), and Microbiology and Immunology (M&I), are the main contributors to the cross-disciplinary nature of the program. These units have established records of federal funding, mentoring junior faculty, graduate student training, and collaborative interactions across campus. We will continue mutually supportive horizontal interactions with other NIH-funded programs at UoL including the Hepatobiology and Toxicology COBRE, and the KY-INBRE, which will enhance the overall research profile of UoL. The activities of the COBRE will help recruit, retain and diversify the faculty. The application is led by well-qualified and well-funded Center Directors. Governance and evaluation are supported by an Internal Advisory Committee (IAC), and an External Advisory Committee (EAC) comprised of five international experts in the thematic area of research. There are three outstanding Research Project Leaders (RPLs) with senior, established, funded mentoring teams with a track record in developing the careers of junior faculty through to independent funding status and further career devlopment. We have developed comprehensive mentoring and career development plans with milestones and evaluative metrics. Similarly, mentors and the COBRE program are evaluated formatively and summatively. We have a strong commitment of support from the UoL which will ensure sustainability beyond the NIH-funded period. The Specific Aims are: to provide the formal governance structure which allows coordination, direction and prioritization of all activities, including budget issues, thus ensuring the quality of all functions and growth of research goals; to administer the process for mentoring and career development of junior faculty and accelerate their transition to independence; coordination of the evaluative processes of the COBRE by the IAC and EAC; budget management including budget reconciliation, and preparing and submitting RPPRs and FFRs; resolution of any conflicts as they arise; management of mechanisms to replace RPLs as they become independent and replacement other key personnel as necessary; administration of the Pilot Program to help maintain a pipeline of investigators; coordination of institutional support; support of clinical, translational and commercialization potential of research projects; provision of biostatistical support; to disseminate pertinent information resulting from the COBRE activities; and ensuring compliance with all relevant regulations and guidelines. All projects and cores will utilize the Administrative Core.