Epigenomic and Genomic Factors emerging from Poor Social Determinants of Health and their impact on Breast Cancer associated with Obesity and Comorbidities in African American and Latino Women
不良健康社会决定因素中出现的表观基因组和基因组因素及其对与非裔美国人和拉丁裔女性肥胖和合并症相关的乳腺癌的影响
基本信息
- 批准号:10349525
- 负责人:
- 金额:$ 32.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-28 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:African AmericanAfrican American populationAgeAreaBiological MarkersBiological PhenomenaBlood specimenBreast Cancer Risk FactorCancer cell lineCardiovascular DiseasesChronicClinicalCommunicable DiseasesCommunitiesCountyDNA MethylationDNA Sequence AlterationDataDiabetes MellitusDiagnosisDiseaseEnvironmental HealthEnvironmental Risk FactorEpigenetic ProcessExposure toGenesGenomicsGonadal Steroid HormonesGrowthGrowth FactorHealthHealthcareHispanicHouseholdHypertensionIncidenceIncidence StudyIncomeIndividualInflammatoryInterventionLatinaLatina PopulationLatinoLatino PopulationLengthLife StyleLiteratureLocationLos AngelesMalignant - descriptorMalignant NeoplasmsMedicineMental HealthMolecularMolecular GeneticsMorbidity - disease rateMutationNeoplasm MetastasisNon-Insulin-Dependent Diabetes MellitusNormal CellObesityOutcomeOutcome StudyParticipantPathway interactionsPhysical environmentPopulationPostmenopausePovertyPrecipitating FactorsPremenopauseRNA methylationReduce health disparitiesResearchResourcesRiskRoleScienceServicesSocial EnvironmentSpecimenTechnologyTimeTissue SampleTranslational ResearchTumor AngiogenesisTumor Suppressor GenesUniversitiesWomanbreast cancer progressioncancer health disparitycancer riskcancer stem cellcancer typechemokinecohortcomorbiditycytokinedemographicsenvironmental stressorepigenomicsfederal poverty levelhealth care availabilityhealth disparityhealth inequalitieshistone modificationhormone receptor-positivemalignant breast neoplasmmethylation patternmortalitynext generation sequencingprecision medicinepublic health relevanceracial and ethnicresponsesocialsocial disadvantagesocial health determinantssocial stressorsocioeconomicsstem cell populationtelomeretumor progression
项目摘要
Abstract:
The Purpose of this study is to determine how social and epigenomic factors that are associated with social
determinants of health cause increase in Obesity and Comorbidities, resulting in increased risk for breast cancer.
Specifically, this study will examine cancer health disparities associated with obesity and other comorbidities in
African American and Latina populations residing South Los Angeles. Multiple reasons have been presented in
the literature suggesting both socioeconomic and biological phenomena which may contribute to these
disparities. Charles R. Drew University of Medicine and Science (CDU) serves the most underserved and under-
resourced populations located in the Service Planning Area 6 (SPA6) region of South Los Angeles. Our
communities comprise primarily of African Americans (27%) and Latinos (68%). From the residents in SPA6,
31% of the population lives in poverty (household income < 100% federal poverty level (FPL)) and median
household income is $36,400, while Los Angeles county is at 17% FPL and with median household income of
$56,241. Healthcare and physical environment resources are significantly poor compared to west Los Angeles
(SPA5).
The Hypothesis and Rationale of this proposed study are: Underserved and Under-resourced communities
with poor social determinants of health, are more likely to develop health disparities such as Obesity, Diabetes
(T2D), and Hypertension (HTN). These individuals are at increased risk for developing several types of cancers.
We will study the incidence and progression of Breast Cancer in these individuals. We will employ biomarkers
such as: Sex Hormones, Growth Factors, Inflammatory Cytokines, DNA Methylation, RNA Methylation, and
Histone Modifications as they relate to Epigenomic and Genomic changes and their association with risk and
clinical outcomes. To accomplish the objectives of our proposal, we will employ the following specific research
aims:
抽象的:
本研究的目的是确定与社会相关的社会和表观基因组因素如何
健康的决定因素会导致肥胖和合并症增加,从而增加患乳腺癌的风险。
具体来说,这项研究将检查与肥胖和其他合并症相关的癌症健康差异
居住在洛杉矶南部的非裔美国人和拉丁裔人口。多种原因已在
文献表明社会经济和生物现象可能有助于这些
差异。查尔斯·R·德鲁医学与科学大学 (CDU) 为服务最匮乏和最缺乏的地区提供服务
位于南洛杉矶服务规划区 6 (SPA6) 地区的资源人口。我们的
社区主要由非裔美国人 (27%) 和拉丁裔美国人 (68%) 组成。来自SPA6的居民,
31% 的人口生活在贫困中(家庭收入 < 100% 联邦贫困线 (FPL)),中位数
家庭收入为 36,400 美元,而洛杉矶县的 FPL 为 17%,家庭收入中位数为
56,241 美元。医疗保健和自然环境资源与洛杉矶西部相比明显较差
(SPA5)。
本拟议研究的假设和基本原理是: 服务不足和资源不足的社区
健康的社会决定因素较差,更有可能出现肥胖、糖尿病等健康差异
(T2D)和高血压(HTN)。这些人患多种癌症的风险增加。
我们将研究这些人乳腺癌的发病率和进展。我们将采用生物标志物
例如:性激素、生长因子、炎症细胞因子、DNA 甲基化、RNA 甲基化,以及
组蛋白修饰与表观基因组和基因组变化及其与风险和风险的关联
临床结果。为了实现我们提案的目标,我们将进行以下具体研究
目标:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jaydutt V. Vadgama其他文献
CCL2/CCR2 signaling in cancer pathogenesis
- DOI:
10.1186/s12964-020-00589-8 - 发表时间:
2020-05-29 - 期刊:
- 影响因子:8.900
- 作者:
Qiongyu Hao;Jaydutt V. Vadgama;Piwen Wang - 通讯作者:
Piwen Wang
RETRACTED ARTICLE: A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells
- DOI:
10.1007/s10549-017-4211-y - 发表时间:
2017-03-23 - 期刊:
- 影响因子:3.000
- 作者:
Yanyuan Wu;Trinh Tran;Sami Dwabe;Marianna Sarkissyan;Juri Kim;Miguel Nava;Sheilah Clayton;Richard Pietras;Robin Farias-Eisner;Jaydutt V. Vadgama - 通讯作者:
Jaydutt V. Vadgama
Retraction Note: A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells
- DOI:
10.1007/s10549-024-07371-1 - 发表时间:
2024-05-10 - 期刊:
- 影响因子:3.000
- 作者:
Yanyuan Wu;Trinh Tran;Sami Dwabe;Marianna Sarkissyan;Juri Kim;Miguel Nava;Sheilah Clayton;Richard Pietras;Robin Farias-Eisner;Jaydutt V. Vadgama - 通讯作者:
Jaydutt V. Vadgama
Jaydutt V. Vadgama的其他文献
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{{ truncateString('Jaydutt V. Vadgama', 18)}}的其他基金
Workshop for Junior Biostatisticians in Health Research
健康研究初级生物统计学家研讨会
- 批准号:
10655012 - 财政年份:2022
- 资助金额:
$ 32.66万 - 项目类别:
Accelerating Excellence in Translational Science (AXIS) - Admin Supplement
加速转化科学卓越 (AXIS) - 管理补充
- 批准号:
10212868 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
Charles Drew University/UCLA Cancer Center Partnership to Eliminate Cancer Health
查尔斯德鲁大学/加州大学洛杉矶分校癌症中心合作消除癌症健康
- 批准号:
8137688 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
Charles Drew University/UCLA Cancer Center Partnership to Eliminate Cancer Health
查尔斯德鲁大学/加州大学洛杉矶分校癌症中心合作消除癌症健康
- 批准号:
8530618 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
Charles Drew University/UCLA Cancer Center Partnership to Eliminate Cancer Health
查尔斯德鲁大学/加州大学洛杉矶分校癌症中心合作消除癌症健康
- 批准号:
8720904 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
Charles Drew University/UCLA Cancer Center Partnership to Eliminate Cancer Health
查尔斯德鲁大学/加州大学洛杉矶分校癌症中心合作消除癌症健康
- 批准号:
7943137 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
CDU-UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities
CDU-UCLA 癌症中心合作消除癌症健康差异
- 批准号:
9150511 - 财政年份:2009
- 资助金额:
$ 32.66万 - 项目类别:
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