Population Studies and Disparities Research

人口研究和差异研究

• 批准号: 10348665
• 负责人: Jennifer L Beebe-Dimmer
• 金额: $ 3.88万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-08 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10348665
• 关键词: Address; Admixture; Adult; Affect; African American; American; Arabs; Area; Automobile Driving; Behavioral; Cancer Center Support Grant; Cancer Survivor; Cancer Survivorship; Catchment Area; Characteristics; Childhood; Clinic; Clinical; Cohort Studies; Collaborations; Colon Carcinoma; Communication; Communication Research; Communities; Comprehensive Cancer Center; Custom; Data; Development; Diagnosis; Discrimination; Disease Progression; Endometrial Carcinoma; Epidemiology; Epigenetic Process; Ethnic Origin; Evidence based intervention; Family member; Funding; Future; Genetic; Goals; Grant; Health; Heritability; Immunity; Incidence; Individual; Inflammation; Intervention; Investigation; Lesbian Gay Bisexual Transgender; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Manuscripts; Metabolic syndrome; Michigan; Minority; Minority Groups; Mission; Molecular; Molecular Epidemiology of Cancer; Molecular Genetics; Obesity; Onset of illness; Outcome; Participant; Patient-Focused Outcomes; Patients; Pattern; Peer Review; Physical activity; Physicians; Population; Population Heterogeneity; Population Study; Prognosis; Publishing; Quality of Care; Race; Reduce health disparities; Research; Research Project Grants; Resources; Risk; Risk Behaviors; Risk Factors; Role; Rural; Rural Population; SEER Program; Schools; Sexual and Gender Minorities; Site; Smoking; Survivors; Susceptibility Gene; System; Targeted Research; Technology; Testing; Treatment outcome; Underserved Population; United States; Universities; Work; analytical method; base; biomarker discovery; cancer diagnosis; cancer epidemiology; cancer health disparity; cancer prevention; cancer risk; clinical practice; clinical research site; cohort; community based research; comorbidity; defined contribution; design; disparity elimination; disparity reduction; eHealth; end of life; ethnic diversity; experience; family genetics; gender minority group; health equity; high risk; high risk population; improved; interest; malignant breast neoplasm; medically underserved; member; metropolitan; mortality; neoplasm registry; novel; outreach; patient-clinician communication; population based; population health; preclinical study; programs; provider behavior; psychosocial; racial bias; racial diversity; recruit; risk stratification; screening; social; survivorship; symptom management; theories; treatment choice; tumor

POPULATION STUDIES AND DISPARITIES RESEARCH – ABSTRACT The Population Studies and Disparities Research (PSDR) Program is committed to identifying key genetic and behavioral risk factors underlying disease onset and progression and developing and testing novel intervention strategies to reduce risk and improve diagnosis, treatment, and outcomes with an emphasis on reducing and/or eliminating cancer health disparities among populations contained within our catchment area. This interactive Program includes 28 members from 11 departments and 3 schools at Wayne State University and $6,936,093 in peer reviewed, cancer-related funding, of which $5,793,590 is from the NCI. The PSDR Program has two overarching scientific themes. The first theme is to investigate the distribution and determinants of cancer risk, survivorship, and outcomes in a racially and ethnically diverse population. Major scientific investigations under this theme use emerging advances in genetics to address our highly-diverse catchment area population that is approximately 25% African American, includes the largest Arab-American community in the US; developing projects target both sexual and gender minority cancer survivors and rural populations within our expanded catchment area. The work is supported by the Detroit area population-based cancer registry, a founding participant in the SEER Program, a resource that is well-leveraged for extensive population-based studies of the epidemiology of lung, breast, prostate, colon, ovarian, and endometrial cancers in diverse populations. The second theme is to develop and test evidence-based interventions focused on patient, family member, and physician behaviors to reduce disparities in cancer prevention, treatment, survivorship, and end-of-life outcomes. The main focus of this theme is modifying social and behavioral factors driving risk behaviors, screening and treatment choices, the quality of physician-patient-family member communication, symptom management, and survivorship in racially and ethnically diverse adult and pediatric populations. The work is supported by a unique, custom-designed video data capture system installed in multiple clinic sites to study the ways racial bias and poor communication give rise to unequal treatment decisions and health outcomes. Future directions include the development of multi-PI grants focused on African American cancer survivors, leveraging the Detroit Research on Cancer Survivors (Detroit ROCS) cohort study. The Detroit ROCS study is the largest single cohort conducted exclusively among African American cancer survivors with a goal of understanding the determinants of poorer outcomes in this population. eHealth technologies to enhance patient-provider communication are also being developed. PSDR Program members actively collaborate with members of the MI, MT, and TBM Programs at KCI. Of the 409 manuscripts published from December 2015 to November 2019, 43% and 25% were intra- and inter-programmatic, respectively, and 74% were multi- institutional collaborations.

人口研究和差异研究-摘要 人口研究和差异研究（PSDR）计划致力于确定关键的遗传 和行为风险因素的基础疾病发作和进展，并开发和测试新的 干预策略，以降低风险，改善诊断，治疗和结果，重点是 减少和/或消除我们的集水区内人口之间的癌症健康差距。 这个互动计划包括来自韦恩州立大学11个系和3个学校的28名成员 以及6，936，093美元的同行评审，癌症相关资金，其中5，793，590美元来自NCI。PSDR 该计划有两个主要的科学主题。第一个主题是调查分布和 癌症风险、生存率和结果的决定因素。主要 这一主题下的科学研究利用遗传学的新进展来解决我们高度多样化的 集水区人口约25%是非洲裔美国人，包括最大的阿拉伯裔美国人， 在美国的社区;发展项目的目标是性和性别少数癌症幸存者和农村 在我们扩大的集水区内的人口。这项工作是由底特律地区人口为基础的支持 癌症登记处，SEER计划的创始参与者，这是一种广泛利用的资源 基于人群的肺癌、乳腺癌、前列腺癌、结肠癌、卵巢癌和子宫内膜癌流行病学研究 在不同的人群中。第二个主题是制定和测试以证据为基础的干预措施， 患者，家庭成员和医生的行为，以减少癌症预防，治疗， 生存率和生命结束的结果。这个主题的主要焦点是修改社会和行为因素 驾驶风险行为，筛查和治疗选择，医生-患者-家属质量 不同种族成人和儿童的沟通、症状管理和生存率 人口。这项工作是由一个独特的，定制设计的视频数据采集系统安装在多个支持 研究种族偏见和沟通不畅如何导致不平等的治疗决定， 健康成果。未来的方向包括发展以非洲裔美国人为重点的多PI赠款 癌症幸存者，利用底特律癌症幸存者研究（底特律ROCS）队列研究。底特律 ROCS研究是专门在非裔美国人癌症幸存者中进行的最大的单一队列研究， 目的是了解这一人群中不良结局的决定因素。电子保健技术，以提高 病人与提供者之间的沟通也在发展之中。PSDR计划成员积极合作， 在KCI的MI，MT和TBM计划的成员。在2015年12月发表的409篇手稿中， 到2019年11月，43%和25%分别是项目内和项目间的，74%是多项目的。 机构合作。