Population Studies and Disparities Research

人口研究和差异研究

• 批准号: 10553191
• 负责人: Jennifer L Beebe-Dimmer
• 金额: $ 3万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-08 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553191
• 关键词: Acceleration; Address; Admixture; Adult; Affect; African American; American; Arabs; Area; Automobile Driving; Behavioral; Cancer Center Support Grant; Cancer Survivor; Cancer Survivorship; Catchment Area; Characteristics; Childhood; Clinic; Clinical; Cohort Studies; Collaborations; Colon Carcinoma; Communication; Communication Research; Communities; Comprehensive Cancer Center; Custom; Data; Development; Diagnosis; Discrimination; Disease Progression; Disparity; Endometrial Carcinoma; Epigenetic Process; Ethnic Origin; Evidence based intervention; Family member; Funding; Future; Genetic; Goals; Grant; Health; Immunity; Incidence; Individual; Inflammation; Institution; Intervention; Investigation; Lesbian Gay Bisexual Transgender; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Manuscripts; Metabolic syndrome; Michigan; Minority; Minority Groups; Mission; Molecular; Molecular Epidemiology of Cancer; Obesity; Onset of illness; Outcome; Participant; Patient-Focused Outcomes; Patients; Peer Review; Physical activity; Physicians; Population; Population Heterogeneity; Population Study; Prognosis; Publishing; Quality of Care; Race; Reduce health disparities; Research; Research Project Grants; Resources; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Role; Rural; Rural Population; SEER Program; Schools; Sexual and Gender Minorities; Site; Smoking; Survivors; Susceptibility Gene; System; Targeted Research; Technology; Testing; Underserved Population; United States; Universities; Work; analytical method; biomarker discovery; cancer diagnosis; cancer epidemiology; cancer health disparity; cancer prevention; cancer risk; clinical practice; clinical research site; cohort; community based research; comorbidity; defined contribution; design; disparity elimination; disparity reduction; eHealth; end of life; epidemiology study; ethnic diversity; experience; family genetics; gender minority group; health equity; heritability pattern; high risk; high risk population; improved; interest; malignant breast neoplasm; medically underserved; member; metropolitan; mortality; neoplasm registry; novel; outreach; patient-clinician communication; population based; population health; preclinical study; programs; provider behavior; psychosocial; racial bias; racial disparity; racial diversity; recruit; risk stratification; screening; social; survivorship; symptom management; theories; treatment choice; tumor

POPULATION STUDIES AND DISPARITIES RESEARCH – ABSTRACT The Population Studies and Disparities Research (PSDR) Program is committed to identifying key genetic and behavioral risk factors underlying disease onset and progression and developing and testing novel intervention strategies to reduce risk and improve diagnosis, treatment, and outcomes with an emphasis on reducing and/or eliminating cancer health disparities among populations contained within our catchment area. This interactive Program includes 28 members from 11 departments and 3 schools at Wayne State University and $6,936,093 in peer reviewed, cancer-related funding, of which $5,793,590 is from the NCI. The PSDR Program has two overarching scientific themes. The first theme is to investigate the distribution and determinants of cancer risk, survivorship, and outcomes in a racially and ethnically diverse population. Major scientific investigations under this theme use emerging advances in genetics to address our highly-diverse catchment area population that is approximately 25% African American, includes the largest Arab-American community in the US; developing projects target both sexual and gender minority cancer survivors and rural populations within our expanded catchment area. The work is supported by the Detroit area population-based cancer registry, a founding participant in the SEER Program, a resource that is well-leveraged for extensive population-based studies of the epidemiology of lung, breast, prostate, colon, ovarian, and endometrial cancers in diverse populations. The second theme is to develop and test evidence-based interventions focused on patient, family member, and physician behaviors to reduce disparities in cancer prevention, treatment, survivorship, and end-of-life outcomes. The main focus of this theme is modifying social and behavioral factors driving risk behaviors, screening and treatment choices, the quality of physician-patient-family member communication, symptom management, and survivorship in racially and ethnically diverse adult and pediatric populations. The work is supported by a unique, custom-designed video data capture system installed in multiple clinic sites to study the ways racial bias and poor communication give rise to unequal treatment decisions and health outcomes. Future directions include the development of multi-PI grants focused on African American cancer survivors, leveraging the Detroit Research on Cancer Survivors (Detroit ROCS) cohort study. The Detroit ROCS study is the largest single cohort conducted exclusively among African American cancer survivors with a goal of understanding the determinants of poorer outcomes in this population. eHealth technologies to enhance patient-provider communication are also being developed. PSDR Program members actively collaborate with members of the MI, MT, and TBM Programs at KCI. Of the 409 manuscripts published from December 2015 to November 2019, 43% and 25% were intra- and inter-programmatic, respectively, and 74% were multi- institutional collaborations.

人口研究和差异研究-摘要