Genetic Susceptibility to Cancers of the Prostate and Urinary Bladder

对前列腺癌和膀胱癌的遗传易感性

• 批准号: 7578330
• 负责人: Jennifer L Beebe-Dimmer
• 金额: $ 13.28万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578330
• 关键词: 22q13; Address; African American; Alleles; Area; Arsenic; Bioinformatics; Bladder; Cancer Control; Cancer-Predisposing Gene; Candidate Disease Gene; Case-Control Studies; Characteristics; Chromosomes; Chromosomes, Human, Pair 22; Clinical; Collection; Coupled; DNA; Data; Development; Disease; Early Diagnosis; Environment; Epidemiologist; Etiology; Familiarity; Family; Funding; Genes; Genetic; Genetic Determinism; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic Research; Genetic Variation; Genotype; Goals; Health; Hereditary Malignant Neoplasm; Individual; Inherited; Investigation; Joints; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Maps; Measures; Mediating; Metabolism; Methodology; Methods; Methylation; Michigan; National Cancer Institute; New England; Participant; Play; Population Study; Primary Prevention; Principal Investigator; Prostate; Research; Research Design; Research Project Grants; Research Proposals; Risk; Role; Sampling; Specimen; Susceptibility Gene; Training; United States; Universities; Urologic Cancer; Variant; Water; Work; anticancer research; base; cancer diagnosis; cancer genetics; cancer risk; cancer site; career; case control; design; epidemiology study; experience; follow-up; genetic analysis; genetic epidemiology; genetic linkage analysis; genome-wide linkage; interest; men; novel; population based; tool

DESCRIPTION (provided by applicant): Project Summary: The overall goal of this proposed research is to estimate the effects of genetic factors on risk of prostate and bladder cancers in two established studies chosen for their distinct design and methodology as well as the candidate's experience and familiarity with the two study populations. The first aim will focus on African American men with inherited forms of prostate cancer participating in the Prostate Cancer Genetics Project. We will perform follow-up investigations of a recent finding suggesting linkage on chromosome 22 among African American families participating in this large family-based study designed to localize one or more prostate-cancer susceptibility genes. We also plan to develop new recruitment strategies to increase participation of African American families to more fully characterize the clinical and genetic characteristics of African Americans with hereditary prostate cancer. The second aim of the project focuses on genetic modifiers of arsenic-mediated bladder cancer risk. We have proposed to investigate the association of several candidate genes that are suspected of influencing the methylation of inorganic arsenic and bladder-cancer risk. We will pool our data with collaborators from the New England Study of Environment and Health to estimate the separate and joint effects of genotype and arsenic exposure. This research plan, which involves the use of largely traditional approaches of genetic analysis to explore novel areas of genetic research, coupled with the proposed formal genetic coursework and experience in a genetics laboratory will serve to broadly develop the genetic training of a cancer epidemiologist who plans to devote her research career to the study of urologic cancers. Relevance: Cancers of the prostate and urinary bladder are two of the most common cancers diagnosed in the United States with strong evidence that genetic susceptibility is an important factor in the development of both cancers. Identifying individuals with an inherited predisposition would be important in developing strategies for the primary prevention and or early detection of disease.

描述（由申请人提供）： 项目摘要：这项拟议研究的总体目标是在两项既定研究中评估遗传因素对前列腺癌和膀胱癌风险的影响，这两项研究因其独特的设计和方法以及候选人对两个研究人群的经验和熟悉程度而被选择。第一个目标将重点关注参与前列腺癌遗传学项目的患有遗传性前列腺癌的非裔美国男性。我们将对最近的一项发现进行后续调查，该发现表明参与这项旨在定位一个或多个前列腺癌易感基因的大型家庭研究的非裔美国家庭中 22 号染色体上存在连锁。我们还计划制定新的招募策略，以增加非裔美国家庭的参与，以更全面地描述患有遗传性前列腺癌的非裔美国人的临床和遗传特征。该项目的第二个目标侧重于砷介导的膀胱癌风险的基因修饰。我们提议研究几个被怀疑影响无机砷甲基化和膀胱癌风险的候选基因的关联。我们将与新英格兰环境与健康研究的合作者汇集数据，以估计基因型和砷暴露的单独和联合影响。该研究计划主要涉及使用传统的遗传分析方法来探索遗传研究的新领域，再加上拟议的正式遗传课程和遗传学实验室的经验，将有助于广泛发展计划将其研究生涯致力于泌尿系统癌症研究的癌症流行病学家的遗传培训。相关性：前列腺癌和膀胱癌是美国最常见的两种癌症，有强有力的证据表明遗传易感性是这两种癌症发生的重要因素。识别具有遗传倾向的个体对于制定疾病的一级预防和/或早期检测策略非常重要。