Detroit Research on Cancer Survivors (Detroit ROCS)

项目摘要/摘要 尽管在早期发现和治疗方面取得了进展，但非裔美国人继续经历 癌症发病率高得不成比例，首先被诊断为更晚期的疾病， 并遭受比其他人口更高的死亡率。底特律对癌症幸存者的研究 (ROCS)研究(U01CA199240)是针对非洲裔美国癌症幸存者的最大单一队列 在理解这一人群较差结果的多重原因方面。底特律的ROC一直是 收集调查数据和生物样本，目标是招收5,000名非洲人 美国人被诊断出患有肺癌、乳腺癌、前列腺癌、结直肠癌和子宫内膜癌，以及任何早期- 初发癌症(确诊年龄为20-49岁)和针对癌症决定因素的支持性研究 结果和生活质量。在这次续签申请中，我们将继续跟踪队列幸存者 每年最多9年，以处理较长期结果的决定因素(例如，疾病 复发、二次初次诊断、与治疗相关的合并症和死亡)和生活质量。 广泛的研究议程将与我们的社区合作伙伴一起制定。我们建议：1)开展 对所有在世的人进行年度跟踪调查，登记的参与者最多额外五年并收集 增加生物样品；2)与社区成员接触，确定新的研究优先事项和 为留住参与者和将研究结果传回给 社区；3)将底特律ROCS患者数据与其他现有的健康相关和暴露来源联系起来 数据以补充患者报告的信息；以及4)扩大合作以促进使用 来自更广泛的研究界的数据和生物质谱学。底特律ROCS正在提供大量数据 和生物检疫剂，以促进旨在了解和解决穷人决定因素的研究 在这一人群中的结果。

Project Summary/Abstract Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The Detroit Research on Cancer Survivors (ROCS) study (U01CA199240) is the largest single cohort of African American cancer survivors aimed at understanding the multiplex causes of poorer outcomes in this population. Detroit ROCS has been collecting survey data and biospecimens with a goal of enrolling 5,000 population-based African Americans diagnosed with lung, breast, prostate, colorectal, and endometrial cancers and any early- onset cancer (diagnosed age 20-49 years) and supporting studies addressing determinants of cancer outcomes and quality of life. In this renewal application, we will continue to follow cohort survivors annually for up to 9 years to address the determinants of longer term outcomes (e.g., disease recurrence, second primary diagnoses, treatment related comorbidities and death) and quality of life. The broad research agenda will be developed with our community partners. We propose to: 1) conduct annual follow-up surveys on all living, enrolled participants for up to five additional years and collect additional biospecimens; 2) engage with members of the community to set new research priorities and to obtain input into the retention of participants and dissemination of research findings back to the community; 3) link Detroit ROCS patient data to other existing sources of health-related and exposure data to supplement patient-reported information; and 4) extend collaborations to facilitate use of the data and biospecimens by the broader research community. Detroit ROCS is providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population.