Detroit Research on Cancer Survivors (Detroit ROCS)

项目总结/摘要 尽管在早期发现和治疗方面取得了进展，但非洲裔美国人继续经历 不成比例的高癌症发病率，首先被诊断为更晚期的疾病， 死亡率比其他人群高。底特律癌症幸存者研究 （ROCS）研究（U 01 CA 199240）是针对非洲裔美国人癌症幸存者的最大单一队列研究， 了解导致这一人群预后较差的多重原因。底特律ROCS已经 收集调查数据和生物标本，目标是招募5，000名非洲人口， 被诊断患有肺癌、乳腺癌、前列腺癌、结肠直肠癌和子宫内膜癌以及任何早期- 初发癌症（诊断年龄20-49岁）和针对癌症决定因素的支持性研究 结果和生活质量。在这次更新申请中，我们将继续跟踪队列幸存者 每年进行一次，为期9年，以解决长期结果的决定因素（例如，疾病 复发、第二主要诊断、治疗相关的合并症和死亡）和生活质量。 广泛的研究议程将与我们的社区合作伙伴一起制定。我们建议：1）进行 每年对所有在世的登记参与者进行为期五年的跟踪调查， 增加生物标本; 2）与社区成员合作，制定新的研究优先事项， 为留住参与者和将研究结果传播回 3）将底特律ROCS患者数据与其他现有的健康相关和暴露来源联系起来 数据，以补充患者报告的信息;和4）扩大合作，以促进使用 更广泛的研究社区的数据和生物标本。底特律ROCS提供了大量的数据 和生物标本，以促进旨在了解和解决贫困决定因素的研究， 这一人群的结果。

Project Summary/Abstract Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The Detroit Research on Cancer Survivors (ROCS) study (U01CA199240) is the largest single cohort of African American cancer survivors aimed at understanding the multiplex causes of poorer outcomes in this population. Detroit ROCS has been collecting survey data and biospecimens with a goal of enrolling 5,000 population-based African Americans diagnosed with lung, breast, prostate, colorectal, and endometrial cancers and any early- onset cancer (diagnosed age 20-49 years) and supporting studies addressing determinants of cancer outcomes and quality of life. In this renewal application, we will continue to follow cohort survivors annually for up to 9 years to address the determinants of longer term outcomes (e.g., disease recurrence, second primary diagnoses, treatment related comorbidities and death) and quality of life. The broad research agenda will be developed with our community partners. We propose to: 1) conduct annual follow-up surveys on all living, enrolled participants for up to five additional years and collect additional biospecimens; 2) engage with members of the community to set new research priorities and to obtain input into the retention of participants and dissemination of research findings back to the community; 3) link Detroit ROCS patient data to other existing sources of health-related and exposure data to supplement patient-reported information; and 4) extend collaborations to facilitate use of the data and biospecimens by the broader research community. Detroit ROCS is providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population.