Shared Resource: Epidemiology Research

摘要 流行病学研究核心(ERC)支持底特律大都市基于人群的癌症研究。 ERC与行为和领域一起被归入人口研究核心集群 研究核心。 ERC位于底特律大都会癌症监测系统(MDCS)内，该系统是由NCI资助的 人口监测、流行病学和最终结果(SEER)计划癌症登记中心。这个 MDCS位于韦恩州立大学(WSU)，隶属于卡马诺斯癌症研究所 (KCI)。底特律和全国SEER数据都包含详细的组织学和人口信息，主要 所有新诊断的浸润性癌症患者各自的治疗和生存数据 地理覆盖范围。 环境研究中心为获取和利用非常复杂的地方和国家SEER提供必要的支持 用于研究的数据。该中心还提供流行病学咨询，并与KCI成员合作 进行癌症预防、病因、治疗和结果方面的调查。这一使命已经完成 通过各种服务，包括快速确定病例；收集医疗记录和生物检验品； 提取用于研究特定信息的医疗记录；将数据集链接到用于诊断的患者数据， 治疗和结果研究；确定以人口为基础的控制人群；研究支持和 培训涉及招募和面谈参与者的研究；数据查询和流行病学专门知识 以及在开展以人口为基础的癌症调查方面的合作。ERC通过以下方式使KCI受益 集中访问SEER数据并标准化研究中的患者、医生和医院交互 使用SEER数据进行基于人口的研究。底特律的大都市人口中有大量的 少数民族，在SEER集水区每年约25,000例癌症诊断中有22%是非洲人 美国人。这使得人群成为研究健康差距的理想对象。ERC贡献了 对KCI进行的基于人口的研究有重大意义，主要是通过确定符合条件的 参与者以及关于这些参与者的数据和生物谱的收集，部分证据是91 在本赠款期间，在对外关系与合作委员会的支持下完成了出版工作。

ABSTRACT The Epidemiology Research Core (ERC) supports population-based cancer research in metropolitan Detroit. The ERC is grouped in the Population Research Core Cluster along with the Behavioral and Field Research Core. The ERC is located within the Metropolitan Detroit Cancer Surveillance System (MDCSS), an NCI-funded population-based Surveillance, Epidemiology and End Results (SEER) Program central cancer registry. The MDCSS is located at Wayne State University (WSU), under the umbrella of the Karmanos Cancer Institute (KCI). Both Detroit and national SEER data contain detailed histological and demographic information, primary treatment and survival data for all patients with newly-diagnosed, invasive cancer in their respective geographic coverage areas. The ERC provides necessary support for access to and utilization of the very complex local and national SEER data for research. The Core also provides epidemiology consulting and collaborates with KCI members conducting investigations in cancer prevention, etiology, treatment and outcomes. This mission is achieved through services including rapid case ascertainment; collection of medical records and biospecimens; abstracting medical records for study-specific information; linkage of datasets to patient data for diagnostic, treatment, and outcomes research; identifying population-based control populations; research support and training for studies involving participant recruitment and interviewing; data queries and epidemiologic expertise and collaboration in the conduct of population-based investigations of cancer. The ERC benefits KCI by centralizing access to SEER data and standardizing patient, physician and hospital interactions for studies using SEER data for population-based research. The metropolitan Detroit population contains a large number of minorities, with 22% of the ~25,000 annual cancer diagnoses in the SEER catchment area being African American. This makes the population ideal for the study of health disparities. The ERC contributes significantly to the population-based research conducted at KCI, primarily through the identification of eligible participants and collection of data and biospecimens on these participants, evidenced in part by the 91 publications accomplished with support of the ERC during the current grant period.