Strategies and Methods for Complex Molecule Synthesis

项目概要/摘要 该计划的目标是开发新的策略和方法， 生物活性次级代谢产物（天然产物）。我们的大部分 将致力于鉴定这些复杂分子的有效制剂。 这些化合物及其独特的衍生物将作为新的小分子， 对抗一系列与癌症以及炎症和疼痛相关的适应症。 我们的合成研究将导致新的应用C-C键活化方法 在有机合成以及网络分析方法的准备， 拓扑复杂分子我们的工作还将突出新的使用方向， 香芹酮作为一种可持续的合成原料。最后，与 合作者，我们将获得独特的进入使用天然产品及其 衍生物干扰生物功能，并最终提供有希望的起点 用于新的疗法。

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–C bond activation methodology in organic synthesis as well as a Network Analysis approach to the preparation of topologically complex molecules. Our work will also highlight new directions for the use of carvone as a sustainable starting material for synthesis. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.