Strategies and Methods for Complex Molecule Synthesis

本届Mira奖(R35GM130345)摘要 这项计划的目标是开发新的战略和方法来合成 生物活性次生代谢物(天然产物)。我们的很大一部分 致力于确定有效的化合物制剂，以及 它们独特的衍生物，将作为新的小分子来对抗一系列 与癌症、炎症和疼痛有关的适应症。我们的合成研究是 重点研究了C-C键裂解方法，新的对映选择性卤化反应和 环加成反应，以及其他分子编辑方法。我们当前的工作 还强调了香芹酮和吡喃酮作为可持续发展的 对映体选择性和对映体特异性合成的起始原料。最后，通过 通过合作，我们将以独特的方式进入天然产品及其 衍生物扰乱生物功能并最终提供有希望的起点 为了新的治疗方法。

Summary of Current MIRA Award (R35GM130345) The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts is dedicated to identifying efficient preparations of compounds, which, along with their unique derivatives, will serve as novel small molecules to combat a range of indications associated with cancer, inflammation, and pain. Our synthetic studies are focused on C–C bond cleavage methodology, novel enantioselective halogenation and cycloaddition reactions, as well other methods for molecular editing. Our current work also highlights new directions for the use of carvone and pyrone as a sustainable starting material for enantioselective and enantiospecific syntheses. Finally, through collaborations, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.