Strategies and Methods for Complex Molecule Synthesis

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Summary of Current MIRA Award (R35GM130345) The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts is dedicated to identifying efficient preparations of compounds, which, along with their unique derivatives, will serve as novel small molecules to combat a range of indications associated with cancer, inflammation, and pain. Our synthetic studies are focused on C–C bond cleavage methodology, novel enantioselective halogenation and cycloaddition reactions, as well other methods for molecular editing. Our current work also highlights new directions for the use of carvone and pyrone as a sustainable starting material for enantioselective and enantiospecific syntheses. Finally, through collaborations, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.