Strategies and Methods for Complex Molecule Synthesis

复杂分子合成的策略和方法

• 批准号: 10387754
• 负责人: Richmond Sarpong
• 金额: $ 7万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10387754
• 关键词: Address; Agriculture; Award; Biological; Biological Process; Carbon; Collaborations; Complex; Disease; Goals; Health; Human; Inflammation; Lead; Malignant Neoplasms; Methodology; Methods; Molecular; Natural Products; Pain; Pharmaceutical Preparations; Preparation; Pyrones; Reaction; Work; combat; cycloaddition; halogenation; novel; novel therapeutics; programs; small molecule

Summary of Current MIRA Award (R35GM130345) The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts is dedicated to identifying efficient preparations of compounds, which, along with their unique derivatives, will serve as novel small molecules to combat a range of indications associated with cancer, inflammation, and pain. Our synthetic studies are focused on C–C bond cleavage methodology, novel enantioselective halogenation and cycloaddition reactions, as well other methods for molecular editing. Our current work also highlights new directions for the use of carvone and pyrone as a sustainable starting material for enantioselective and enantiospecific syntheses. Finally, through collaborations, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.

当前MIRA奖（R35 GM 130345）的摘要 该计划的目标是开发新的策略和方法， 生物活性次级代谢产物（天然产物）。我们的大部分 致力于鉴定化合物的有效制剂，其沿着 它们独特的衍生物，将作为新的小分子，以打击一系列的 与癌症、炎症和疼痛相关的适应症。我们的合成研究是 专注于C-C键断裂方法，新型对映选择性卤化和 环加成反应，以及其他用于分子编辑的方法。当前工作 还强调了香芹酮和吡喃酮作为一种可持续的 对映选择性和对映特异性合成的起始材料。最后通过 合作，我们将获得独特的进入使用天然产品及其 衍生物干扰生物功能，并最终提供有希望的起点 用于新的疗法。