Novel Strategies for Natural Products Synthesis

描述（由申请人提供）：该计划的目标是定义新的策略和方法，用于合成二萜生物碱家族中的生物活性分子。我们构建的复杂分子可以提供研究离子通道的工具，并可能最终用于开发新的治疗方法。我们的合成研究也应该导致更好地理解有机官能团的反应性，因为我们的目标在拥挤的环境中拥有众多的官能团。具体而言，我们打算开发策略，以合成不同结构类别的二萜生物碱，包括coryphine，kobusine和cossonidine。我们期望我们独特的合成策略和方法来简化获得独特的离子通道增效剂。

DESCRIPTION (provided by applicant): The goal of this program is to define new strategies and methods for the synthesis of bioactive molecules in the diterpenoid alkaloid family. The complex molecules that we construct can provide tools to study ion channels and may ultimately be used to develop new therapeutics. Our synthetic studies should also lead to a better understanding of organic functional group reactivity since our targets possess a multitude of functional groups in a congested setting. Specifically, we intend to develop strategies to synthesize different structural classes of diterpenoid alkaloids including coryphine, kobusine and cossonidine. We expect our unique strategies and methods for synthesis to streamline access to unique ion channel potentiators.