Renewal: Strategies and Methods for Complex Molecule Synthesis

项目摘要/摘要 这项计划的目标是开发新的战略和方法来合成 生物活性次生代谢物(天然产物)。很大一部分 我们将致力于确定这些复合体的有效制剂 分子。这些化合物及其独特的衍生品将作为新的小分子 对抗一系列与癌症相关的适应症的分子以及 炎症和疼痛。我们的合成研究将导致C-H，C-C的新应用 C-N键功能化方法在有机合成中的应用及进展 骨架编辑的概念及其在拓扑学准备中的应用 复杂的分子。最后，与合作者合作，我们将获得独特的进入 使用天然产物及其衍生物来扰乱生物功能和 最终为新的疗法提供了有希望的起点。

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–H, C–C and C–N bond functionalization methodology in organic synthesis as well as advancing the concept of skeletal editing and its application to the preparation of topologically complex molecules. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.