Total Synthesis of Bioactive Natural Products

 描述（由申请人提供）：该项目的目标是开发合成异戊烯化吲哚生物碱家族生物活性分子的新策略。我们构建的复杂天然产物及其独特的衍生物只能使用我们的策略获得，这些衍生物将提供小分子，作为识别通过新机制发挥作用的抗癌化合物的起点。我们的合成研究也应该导致深入了解异戊二烯化吲哚生物碱的一个子集的生物合成， 生物起源尚未建立。具体而言，我们打算开发策略，以合成不同结构类别的异戊二烯化吲哚生物碱，包括citrinalins，cyclopiamine，citrinadins和stephacidins。

 DESCRIPTION (provided by applicant): The goal of this program is to develop new strategies for the synthesis of bioactive molecules in the prenylated indole alkaloid family. The complex natural products that we construct, and their unique derivatives which are only accessible using our strategies, will provide small molecules that will serve as a starting point to identify anticancer compounds that function via novel mechanisms. Our synthetic studies should also lead to insights into the biosynthesis of a subset of the prenylated indole alkaloids for which the biogenesis is not established. Specifically, we intend to develop strategies to synthesize different structural classes of prenylated indole alkaloids including the citrinalins, cyclopiamine, citrinadins and the stephacidins.