Total Synthesis of Bioactive Natural Products

 描述(由申请人提供)：该计划的目标是开发合成戊烯基吲哚生物碱家族中的生物活性分子的新策略。我们构建的复杂天然产品及其独特的衍生品只有通过我们的策略才能获得，它们将提供小分子，作为鉴定通过新机制发挥作用的抗癌化合物的起点。我们的合成研究还应有助于深入了解一组戊烯基化吲哚生物碱的生物合成 生物发生还没有建立起来。具体地说，我们打算开发策略来合成不同结构类别的戊烯基化吲哚生物碱，包括桔青素、环匹胺、桔红素和千金藤素。

 DESCRIPTION (provided by applicant): The goal of this program is to develop new strategies for the synthesis of bioactive molecules in the prenylated indole alkaloid family. The complex natural products that we construct, and their unique derivatives which are only accessible using our strategies, will provide small molecules that will serve as a starting point to identify anticancer compounds that function via novel mechanisms. Our synthetic studies should also lead to insights into the biosynthesis of a subset of the prenylated indole alkaloids for which the biogenesis is not established. Specifically, we intend to develop strategies to synthesize different structural classes of prenylated indole alkaloids including the citrinalins, cyclopiamine, citrinadins and the stephacidins.