Strategies and Methods for Complex Molecule Synthesis

复杂分子合成的策略和方法

• 批准号: 10079497
• 负责人: Richmond Sarpong
• 金额: $ 59.95万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079497
• 关键词: Address; Agriculture; Biological; Biological Process; Carbon; Complex; Disease; Goals; Health; Human; Hydrogen; Inflammation; Lead; Malignant Neoplasms; Methodology; Methods; Natural Products; Organic Synthesis; Pain; Pathway Analysis; Pharmaceutical Preparations; Preparation; Work; combat; novel; novel therapeutics; programs; small molecule

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–C bond activation methodology in organic synthesis as well as a Network Analysis approach to the preparation of topologically complex molecules. Our work will also highlight new directions for the use of carvone as a sustainable starting material for synthesis. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.

项目摘要/摘要 这项计划的目标是开发新的战略和方法来合成 生物活性次生代谢物(天然产物)。我们的很大一部分 将致力于确定这些复杂分子的有效制剂。 这些化合物及其独特的衍生物将作为新的小分子用于 抗击一系列与癌症、炎症和疼痛有关的适应症。 我们的合成研究将导致C-C键活化方法学的新应用 以及网络分析方法在有机合成中的应用 拓扑结构复杂的分子。我们的工作还将突出新的使用方向 香芹酮作为一种可持续的合成起始原料。最后，使用 合作者，我们将获得独特的进入使用天然产品和他们的 衍生物扰乱生物功能并最终提供有希望的起点 为了新的治疗方法。