Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network

尤尼斯·肯尼迪·施赖弗 (Eunice Kennedy Shriver) NICHD 合作多中心新生儿研究网络

• 批准号: 10352227
• 负责人: Ravi Mangal Patel
• 金额: $ 23.32万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10352227
• 关键词: Address; Administrator; Admission activity; Advocate; Applications Grants; Area; Biology; Birth; Cardiovascular system; Caring; Centers for Disease Control and Prevention (U.S.); Cesarean section; Child; Child Health; Child Welfare; Child health care; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communicable Diseases; Communities; Country; Data Collection; Development; Discipline of obstetrics; Disease; Doctor of Philosophy; Environment; Faculty; Family; Financial Support; Fostering; Funding; Future; Goals; Grant; Gynecology; Health; Healthcare; Healthcare Systems; Hematological Disease; Hospitals; Infant; Infrastructure; Institutes; Institution; International; Laboratories; Lead; Leadership; Letters; Link; Liquid substance; Lung; Malignant Neoplasms; Maternal-fetal medicine; Medical; Medical Staff; Medicine; Mission; Mucosal Immunity; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Neonatology; Neurodevelopmental Impairment; Neurosciences; Newborn Infant; Nursing Research; Observational Study; Operative Surgical Procedures; Outcome; Pathology; Patients; Pediatrics; Peer Review; Perinatal; Perinatal Infection; Personal Satisfaction; Physiology; Population Heterogeneity; Premature Infant; Prevention; Process; Productivity; Progress Reports; Public Health Nursing; Publications; Research; Research Personnel; Research Priority; Research Project Grants; Risk Factors; Role; Science; Scientist; Services; Site; Sodium; Strategic Planning; Talents; Time; Training; Translating; Translational Research; Transplantation Immunology; United States National Institutes of Health; Universities; University Hospitals; Very Low Birth Weight Infant; Work; biomedical referral center; clinical care; clinical center; drug development; epidemiology study; experience; fetal; follow-up; gut inflammation; high risk; high risk infant; improved; innovation; interest; lung injury; maternal risk; medical schools; metropolitan; mortality; multidisciplinary; neonatal care; neonatal morbidity; pediatric department; perinatal medicine; professor; programs; public health relevance; recruit; research facility; response; success; survival outcome; vaccine development

 DESCRIPTION (provided by applicant): This application highlights the ability and commitment of Emory University's Division of Neonatology to continue its 24 year participation in the Eunice Kennedy Shriver NICHD Multicenter Neonatal Research Network (NRN). An overview of the robust research environment at Emory and the active research programs of the Division are detailed. We provide medical services and recruit study patients at three hospitals in metropolitan Atlanta, which include: Grady Memorial Hospital, the largest hospital in Georgia; Emory University Hospital Midtown, a high-risk maternal center; and Children's Healthcare of Atlanta at Egleston, a tertiary referral center. These sites care for over 7,000 births, 1,750 neonatal admissions and 350 surgical cases per year, with a diverse population with unparalleled pathology, providing an excellent setting to address important research questions. The Neonatal Division has collaborated effectively with the other Pediatric divisions and departments at Emory and at other institutions. A unique strength is our close academic link to scientists at the Centers for Disease Control and Prevention as well as strong institutional research strength and programs in the neurosciences; developmental lung biology; transplant/immunology; infectious diseases, particularly neonatal-perinatal infections; drug and vaccine development; mucosal immunity/intestinal inflammation; cancer and blood disorders; cardiovascular development and biology; and epidemiologic studies and clinical trials in neonatal-perinatal medicine. In response to the RFA, our grant application reviews Emory's participation in the NRN; clinical and research facilities; obstetrical and neonatal cooperation; medical staff and support services; the diverse population available for clinical research; maternal-fetal medicine; perinatal data collection; the high-risk infant follow-up program; our superb experienced research nurses; neonatologist research and staffing; and special research strengths of Emory and Atlanta. Dr. David Carlton, Alternate-PI since 2007, will lead the Emory site as PD/PI. He is a recognized lung biologist, with demonstrated ability to work collaboratively with other investigators, clinical centers, and scientific groups. Dr. Lucky Jain, an established clinical investigator and internationally renowned researcher in the area of lung fluid clearance, will resume his role as alternate PD/PI. Dr. Ira Adams-Chapman, NRN follow-up PI, is an established follow-up investigator who has made important contributions to the NRN. Dr. Carlton and our entire Neonatal Division are enthusiastic in their commitment to the NRN and the advancement of neonatal medicine through collaborative NRN studies.



项目成果

Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.

• DOI: 10.1016/j.jpeds.2011.05.042
• 发表时间: 2011-12
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
• 通讯作者: Higgins, Rosemary D.

Cytokines and posthemorrhagic ventricular dilation in premature infants.

• DOI: 10.1055/s-0032-1316443
• 发表时间: 2012-10
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Ambalavanan N;Carlo WA;McDonald SA;Das A;Schendel DE;Thorsen P;Hougaard DM;Skogstrand K;Higgins RD;Cytokine and Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network
• 通讯作者: Cytokine and Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network

Vitamin A supplementation in extremely low-birth-weight infants: subgroup analysis in small-for-gestational-age infants.

• DOI: 10.1055/s-0032-1333410
• 发表时间: 2013-10
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Londhe VA;Nolen TL;Das A;Higgins RD;Tyson JE;Oh W;Devaskar SU;Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
• 通讯作者: Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Immunogenicity of Haemophilus influenzae type b protein conjugate vaccines in very low birth weight infants.

B 型流感嗜血杆菌蛋白结合疫苗对极低出生体重婴儿的免疫原性。

• DOI: 10.1097/01.inf.0000437263.04493.7c
• 发表时间: 2013
• 期刊: The Pediatric infectious disease journal
• 作者: D'Angio,CarlT;Murray,TheresaE;Li,Lei;Heyne,RoyJ;O'Shea,TMichael;Schelonka,RobertL;Shankaran,Seetha;Duara,Shahnaz;Goldberg,RonaldN;Stoll,BarbaraJ;Stevenson,DavidK;Vohr,BettyR;Phelps,DaleL;Carlo,WaldemarA;Pichichero,M
• 通讯作者: Pichichero,M

Male/female differences in indomethacin effects in preterm infants.

早产儿吲哚美辛作用的男性/女性差异。

• DOI: 10.1016/j.jpeds.2005.07.032
• 发表时间: 2005
• 期刊: The Journal of pediatrics
• 作者: Ohlsson,Arne;Roberts,RobinS;Schmidt,Barbara;Davis,Peter;Moddeman,Diane;Saigal,Saroj;Solimano,Alfonso;Vincer,Michael;Wright,Linda;TrialOfIndomethacinProphylaxisInPretermsTippInvestigators
• 通讯作者: TrialOfIndomethacinProphylaxisInPretermsTippInvestigators