Bio-Behavioral Core

生物行为核心

• 批准号: 10765797
• 负责人: WOLF E MEHLING
• 金额: $ 89.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-25 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10765797
• 关键词: Bio; Behavioral; Core

The integrated biopsychosocial model of chronic low back pain (cLBP) acknowledges that interactions of biological, psychological and social factors determine the course of LBP. The goal of this research core is to contribute the bio-behavioral perspective. In close cooperation with the other cores of UCSF REACH, it will add the neuroscience and psychological expertise and state-of-the-art technology to be integrated with biomechanic and structural parameters. This CORE will leverage existing resources (SFVAHCS MRI), existing clinical cohorts (Spine Center; SFVAHCS), and existing datasets to conduct bio-behavioral research leading to further characterization of LBP mechanisms and improved phenotyping of patients with cLBP. We will accomplish these goals with the following Specific Aims: Aim 1: To provide, maintain, and support state-of-the-art self-report measures, quantitative sensory testing (QST) and brain imaging methods for evaluating and classifying individual processing of cLBP: A. Behavioral Self-Report Measures / Patient-Reported Outcomes using a comprehensive battery of a) NIH- recommended, b) validated supplemental and c) emergent psychological self-report outcome measures. 1) Quantitative Sensory Testing to assess perception, pain and tolerance thresholds, and various indices assessing endogenous pain modulatory capacity using validated psychophysical tests. 2) Functional MRI with application of an experimental pain task to separately evaluate components of the pain experience and determine which neural networks are mostly affected by variations of cLBP phenotypes. 3) Structural MRI and Diffusion MRI to assess cortical/subcortical structural plasticity and microstructure within various cLBP phenotypes. Aim 2: To provide infrastructure for validation and clinical utility determination for the emerging biobehavioral data elements in individuals with cLBP We will facilitate evaluation of the clinical utility in a separate sample of individuals with cLBP undergoing an intensive pain rehabilitation program. Data will be fed continuously into the Informatics Core and analyzed in close cooperation with all Cores of the Mechanistic Center and with other Centers across the BACPAC Consortium. Aim 3: To develop and provide evidence-based novel interventions for cLBP. To strengthen the Bio-Behavioral Core's capabilities for studying innovative behavioral treatment approaches, we will develop and validate innovative interventions based on mindfulness-based theories. Aim 4: To provide forums for stimulating collaboration, learning, and improving upon our current approaches where we will present new research and technology innovation to the REACH and BACPAC communities.

慢性腰痛（CLBP）的综合生物心理社会模型承认 生物，心理和社会因素决定了LBP的进程。该研究核心的目的是 贡献生物行为的观点。与UCSF的其他核心密切合作，它将添加 神经科学和心理专业知识和最先进的技术将与 生物力学和结构参数。该核心将利用现有资源（SFVAHCS MRI），现有 临床队列（脊柱中心； SFVAHCS）和现有的数据集进行生物行为研究，导致 LBP机制的进一步表征和CLBP患者的表型改善。我们将 实现以下特定目标来实现这些目标： 目标1：提供，维护和支持最新的自我报告措施，定量感官测试 （QST）和大脑成像方法用于评估和分类CLBP的个人处理： A.行为自我报告措施 /患者报告的结果，使用a）NIH-的综合电池 建议，b）经过验证的补充和c）出现的心理自我报告结果指标。 1）定量感觉测试评估感知，疼痛和公差阈值以及各种指标 使用经过验证的心理物理测试评估内源性疼痛调节能力。 2）功能性MRI通过应用实验性疼痛任务分别评估疼痛的组成部分 经验并确定哪些神经网络主要受CLBP表型变化的影响。 3）结构MRI和扩散MRI评估皮质/皮层结构可塑性和微观结构 各种CLBP表型。 目标2：为新兴生物行为提供验证和临床实用性确定基础架构 CLBP个体的数据元素 我们将促进对CLBP的单独样本中的临床实用性的评估 密集疼痛康复计划。数据将连续馈送到信息学核心中并进行分析 与机械中心的所有核心以及BACPAC的其他中心密切合作 财团。 目标3：开发并为CLBP提供基于证据的新颖干预措施。 增强生物行为核心研究创新行为治疗的能力 方法，我们将根据基于正念的理论制定和验证创新干预措施。 目标4：提供刺激协作，学习和改进我们当前方法的论坛 我们将向Reach和Bacpac社区展示新的研究和技术创新。