Bio-Behavioral Core

生物行为核心

• 批准号: 10765797
• 负责人: WOLF E MEHLING
• 金额: $ 89.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-25 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10765797
• 关键词: Bio; Behavioral; Core

The integrated biopsychosocial model of chronic low back pain (cLBP) acknowledges that interactions of biological, psychological and social factors determine the course of LBP. The goal of this research core is to contribute the bio-behavioral perspective. In close cooperation with the other cores of UCSF REACH, it will add the neuroscience and psychological expertise and state-of-the-art technology to be integrated with biomechanic and structural parameters. This CORE will leverage existing resources (SFVAHCS MRI), existing clinical cohorts (Spine Center; SFVAHCS), and existing datasets to conduct bio-behavioral research leading to further characterization of LBP mechanisms and improved phenotyping of patients with cLBP. We will accomplish these goals with the following Specific Aims: Aim 1: To provide, maintain, and support state-of-the-art self-report measures, quantitative sensory testing (QST) and brain imaging methods for evaluating and classifying individual processing of cLBP: A. Behavioral Self-Report Measures / Patient-Reported Outcomes using a comprehensive battery of a) NIH- recommended, b) validated supplemental and c) emergent psychological self-report outcome measures. 1) Quantitative Sensory Testing to assess perception, pain and tolerance thresholds, and various indices assessing endogenous pain modulatory capacity using validated psychophysical tests. 2) Functional MRI with application of an experimental pain task to separately evaluate components of the pain experience and determine which neural networks are mostly affected by variations of cLBP phenotypes. 3) Structural MRI and Diffusion MRI to assess cortical/subcortical structural plasticity and microstructure within various cLBP phenotypes. Aim 2: To provide infrastructure for validation and clinical utility determination for the emerging biobehavioral data elements in individuals with cLBP We will facilitate evaluation of the clinical utility in a separate sample of individuals with cLBP undergoing an intensive pain rehabilitation program. Data will be fed continuously into the Informatics Core and analyzed in close cooperation with all Cores of the Mechanistic Center and with other Centers across the BACPAC Consortium. Aim 3: To develop and provide evidence-based novel interventions for cLBP. To strengthen the Bio-Behavioral Core's capabilities for studying innovative behavioral treatment approaches, we will develop and validate innovative interventions based on mindfulness-based theories. Aim 4: To provide forums for stimulating collaboration, learning, and improving upon our current approaches where we will present new research and technology innovation to the REACH and BACPAC communities.

慢性下腰痛(CLBP)的综合生物心理社会模型承认 生物、心理和社会因素决定了LBP的进程。这一研究核心的目标是 贡献出生物行为的观点。与加州大学旧金山分校REACH的其他核心密切合作，它将增加 神经科学和心理学的专业知识和最先进的技术将与 生物力学和结构参数。此核心将利用现有资源(SFVAHCS MRI)、 临床队列(脊柱中心；SFVAHCS)和现有数据集，以进行生物行为研究，从而导致 LBP机制的进一步表征和慢性LBP患者的改进表型。我们会 实现这些目标的具体目标如下： 目标1：提供、维护和支持最先进的自我报告措施、定量感觉测试 (QST)和脑成像方法评估和分类cLBP的个体处理： A.行为自我报告措施/患者报告的结果，使用一套全面的a)NIH- 建议，b)经过验证的补充措施，c)紧急心理自我报告结果措施。 1)量化感官测试，评估知觉、疼痛和耐受阈值，以及各种指数 使用有效的心理物理测试评估内源性疼痛调节能力。 2)应用实验性疼痛任务的功能磁共振成像来分别评估疼痛的组成部分 体验并确定哪些神经网络最受cLBP表型变化的影响。 3)结构磁共振成像和弥散磁共振成像评估皮质/皮质下结构的可塑性和微结构 各种cLBP表型。 目的2：为新出现的生物行为的验证和临床效用确定提供基础设施 慢性腰痛患者的数据元素 我们将在一个单独的慢性下腰痛患者样本中促进对其临床效用的评估 强化疼痛康复计划。数据将持续输入信息学核心，并在 与机械中心的所有核心以及整个园区的其他中心密切合作 财团。 目的3：为慢性下腰痛开发和提供循证的新型干预措施。 加强生物行为核心研究创新行为治疗的能力 方法，我们将开发和验证基于正念理论的创新干预方法。 目标4：为促进协作、学习和改进我们当前的方法提供论坛 在那里，我们将向REACH和BACPAC社区展示新的研究和技术创新。