Bio-Behavioral Core

生物行为核心将推动高影响力的、集成的生物医学、行为和社会科学 艾滋病毒预防和护理研究--从概念化到提交提案，从数据收集到 解读和传播。虽然有效的联合抗逆转录病毒疗法(ART)可以减少艾滋病毒 随着艾滋病的传播，新的感染继续发生，每年确诊的病例都超过了死亡人数。每一种生物医学 预防和治疗艾滋病毒感染的战略(如ART、PrEP、PEP、阴道套环、避孕套、 杀微生物剂、未来的疫苗和广泛中和的单抗]具有行为成分 影响疗效和有效性的药物。除非生物医学策略是可接受的，广泛传播的， 并坚持并考虑到精神健康、药物使用和健康等共病 和社会差异，它们对艾滋病流行的影响将是有限的。生物行为核心将提供 综合生物医学、行为和社会科学以及临床观点的综合方法 在艾滋病毒预防和治疗研究方面，以综合学理论为指导框架，推进生物医学 行为研究。核心有三个具体目标：(1)刺激高影响力的生物行为研究 关于生物医学和行为科学之间的新出现的优先主题；(2)提供关于 生物措施的选择、样本采集和化验以及对结果数据的解释；以及(3) 通过与艾滋病毒和非艾滋病毒护理提供者建立伙伴关系，优先考虑临床前景。 生物行为核心将通过包括专家在内的一系列职能来实现其目标 向艾滋病毒中心研究人员咨询研究设计、干预开发、生物标记物、社会 科学理论，以及与提供者的研究伙伴关系；科学工作组，综合各种 由生物医学、临床和社会科学研究人员组成的团队走到一起，开发出具有竞争力的 应对最紧迫的临床、科学和政策挑战的研究建议；以及年度研讨会 将杰出的研究人员带到艾滋病毒中心，对选定的紧迫科学进行深入探索 两难境地，以激发新的科学问题，并最终提出多学科研究拨款建议。我们 将确定架起学科孤岛的共同科学目标；建立协作的跨学科团队 解决这些目标；并支持综合生物行为研究议程。核心总监将是 Laurie Bauman博士，社会学家，儿科学教授，预防干预主任 阿尔伯特·爱因斯坦医学院的研究中心。核心联席董事，医学博士，Michael Yen是一位 哥伦比亚大学医学副教授，管理PLWH的护理，提供PrEP相关 他是CUMC艾滋病临床试验小组(ACTG)的研究员。通过其强大的 在行为、社会和生物医学科学以及临床研究和护理方面的成员和附属机构，生物- 行为核心将提供必要的基础设施，以支持中心范围的学习社区。

The Bio-Behavioral Core will advance high-impact, integrated biomedical, behavioral, and social science research in HIV prevention and care from conceptualization to proposal submission and from data collection to interpretation and dissemination. Although effective combination antiretroviral therapy (ART) can reduce HIV transmission, new infections continue to occur, and diagnoses surpass deaths each year. Every biomedical strategy for preventing and treating HIV infection (e.g., ART, PrEP, PEP, intravaginal rings, condoms, microbicides, and future vaccines and broadly neutralizing monoclonal antibodies] has behavioral components that influence efficacy and effectiveness. Unless biomedical strategies are acceptable, widely disseminated, and adhered to and take into consideration co-morbidities such as mental health and substance use and health and social disparities, their impact on the AIDS epidemic will be limited. The Bio-Behavioral Core will provide a comprehensive approach that integrates biomedical, behavioral and social science, and clinical perspectives for HIV prevention and treatment research, using Syndemics Theory as a guiding framework for advancing bio- behavioral research. The Core has three Specific Aims: (1) to stimulate high-impact bio-behavioral research on emerging priority topics at the interface of biomedical and behavioral science; (2) to provide expertise on selection of biological measures, sample collection and assay, and interpretation of resulting data; and (3) to prioritize clinical perspectives through partnerships with HIV and non-HIV care providers. The Bio-Behavioral Core will accomplish its Aims through a range of functions that include expert consultation to HIV Center researchers on research design, intervention development, biomarkers, social science theories, and research partnerships with providers; Scientific Working Groups, integrated diverse teams of biomedical, clinical, and social science researchers who come together to develop competitive research proposals that meet the most pressing clinical, scientific, and policy challenges; and annual Symposia that bring preeminent researchers to the HIV Center for intensive exploration of selected pressing scientific dilemmas to stimulate new scientific questions and, ultimately, multidisciplinary research grant proposals. We will identify shared scientific goals that bridge disciplinary silos; build collaborative interdisciplinary teams to address these goals; and support an integrated bio-behavioral research agenda. The Core Director will be Laurie Bauman, Ph.D., a sociologist, Professor of Pediatrics, and Director of the Prevention Intervention Research Center at the Albert Einstein College of Medicine. Core Co-Director, Michael Yin, M.D., is an Associate Professor of Medicine at Columbia University who manages care for PLWH, provides PrEP-related services, and is an investigator in the CUMC AIDS Clinical Trials Group (ACTG). Through the strengths of its Members and Affiliates in behavioral, social, and biomedical sciences and clinical research and care, the Bio- Behavioral Core will provide essential infrastructure to support a Center-wide learning community.