Center for Applied Immunology and Pathological Processes

项目摘要/摘要 需要一个正常运作和有效的免疫系统来控制细菌、病毒和 其他病原体入侵，异常细胞的生长，以及胚胎的正常发育，伤口愈合， 骨骼重塑和其他正常的动态平衡过程。因此，理解先天的和适应性的 慢性炎症条件下的免疫反应和异常如何影响人类健康 新生儿发育以及传染病和癌症如何颠覆或改变这些反应是至关重要的 改善我们的健康，不仅是在美国，而且是在全球。不幸的是，在离家更近的地方，这一点仍然存在 路易斯安那州尤其如此，该州在许多全国健康研究中排名接近垫底。为 例如，该州人类免疫缺陷病毒(HIV)年龄调整后的死亡人数是 全国平均水平，虽然该州在性传播疾病、梅毒、 淋病和衣原体。此外，根据南部许多州的记录，路易斯安那州有一些 关节炎(该州每4个成年人中就有1人患病)、心脏病和心血管死亡的比率最高 (分别排在第46/50和48/50位)，以及癌症相关死亡率(比全国高出15%-20% 平均)。这些明显的统计数据支持了对发病机制进一步了解的必要性 这些疾病的风险和治疗干预的新选择。这些不同的主题中有一个共同的主题 疾病是一种异常的免疫反应和由此产生的免疫病理。因此，我们提出了一种更好的 了解免疫系统的异常如何导致疾病是很有必要的。我们建议有针对性的 我校以免疫学为中心的中心的发展将对我们的健康产生积极的影响 公民们。这一点尤其正确，因为新的研究表明，免疫反应或 免疫疗法作为控制和根除各种肿瘤的有效治疗选择前景广阔， 治疗和减轻对抗生素或抗病毒有抵抗力的传染病，并预防 慢性炎症性疾病等 在免疫学、宿主病原体相互作用和免疫病理学方面的不同研究 与异常免疫反应相关的是路易斯安那州立大学健康科学中心的重要优先事项 什里夫波特(LSUHSC-S)在多个中心和部门内。免疫学作为一门学科可以有效地 将目前在校园内的许多中心和部门连接起来，从而成为协作和 跨不同学科的协同研究。免疫学作为一门学科现在处于小说的前沿 控制细菌感染、病毒感染、治疗癌症的疗法；因此，它的扩展和增长 LSUHSC-S专区将推进学校的使命，发展具有很强翻译能力的基础科学 潜力。这个新的科布雷应用免疫学和病理过程中心的目标是 (CAIPP)建立独立的国际认可的研究和培训计划 LSUHSC-S。我们建议首先指导和发展联邦资助的初级教员研究和开发 新的基础设施，以支持这一重要的生物医学科学领域的增长和继续招聘。 由于Yurochko博士在免疫学研究方面有35年的经验，一直是科布雷的初级PI 中心，成功项目的项目导师，科布雷领导团队的一员，他可以利用财富 这些经验和经验以及有经验的领导团队的经验，推动了CAIPP的成功。第二, 我们建议长期留住这些免疫学研究人员，因为他们通过晋升变得更资深， 成为国际公认的研究中心，提升大学S的CAIPP水平 一个州认可的中心。我们将利用目前校园内的优势，通过有针对性的 围绕“免疫细胞功能异常和免疫功能异常”的重点理解来培养CAIPP眼镜蛇 由此产生的免疫病理学“。这些核心解决了校园内的关键研究需求，并最终 对LSUHSC-S的长期增长和研究现状至关重要。核心建立在现有设备的基础上 和基础设施，并带来校园中目前无法获得的新专业知识；因此，它们填补了 研究基础设施。最近对所有中心和大多数教职员工(80%)的教职员工文件进行的民意调查 园区将利用/需要两个提议的核心来生成竞争性国家拨款所需的新数据 意见书。总之，CAIPP Cobre应用程序的主要目标是：建立一个强大的 始终如一的指导和专业发展计划，满足每个调查员的个人需求 (并因此为该调查员的需求量身定做)；建立先进的研究核心设施，以支持 大学、地区和国家；推进对如何颠覆的机理和临床认识 免疫细胞的免疫反应和功能影响人类健康和疾病；最后 创建一个学术和经济上独立、国际公认的卓越中心。我们 通过我们在学校内的中心和部门内的初始合作，以及 整个州北部地区，然后通过接触和合作发展这种合作 一旦我们为拟议的CAIPP奠定了基础，我们就会与该州其他地区的同事进行交流。

PROJECT SUMMARY/ABSTRACT A properly functioning and effective immune system is needed to control infection by bacterial, viral and other pathogen invaders, growth of aberrant cells, as well as for proper embryonic development, wound healing, bone remodeling, and other normal homeostatic processes. Thus, understanding the innate and adaptive immune responses and how abnormalities affect human health in chronic inflammatory conditions, during neonatal development and how infectious diseases and cancers subvert or alter these responses is critical to improving our health, not only in the United States, but globally. Closer to home, this unfortunately remains especially true in the state of Louisiana, which ranks near the bottom in many national health studies. For example, human immunodeficiency virus (HIV) age adjusted deaths in the state are more than double the national average, while the state ranks in the top 5 in infections with the sexually transmitted diseases, Syphilis, Gonorrhea and Chlamydia. In addition, as is documented for many states in the south, Louisiana has some of the highest rates of arthritis (affecting ~1 in 4 adults in the state), heart disease and cardiovascular deaths (ranked 46/50 and 48/50 respectively), and cancer-related mortality rates (15-20% higher than the national average) in the nation. These glaring statistics support the need for additional understanding of the pathogenesis of these diseases and new options for therapeutic interventions. One common theme among these different diseases is an aberrant immune response and resulting immunopathologies. Thus, we propose a better understanding of how aberrations in the immune system result in disease is needed. We propose that a targeted growth of an immunology-centric center on our campus at LSUHSC-S will positively influence the health of our citizens. This is especially true as new research shows targeted modifications of the immune response or immunotherapy holds great promise as an effective treatment option to control and eradicate various tumors, for the treatment and mitigation of antibiotic or antiviral resistant infectious diseases, and for the prevention of chronic inflammatory diseases, etc. Diverse research into aspects of immunology, host pathogen interactions, and the immunopathology associated with an abnormal immune response is an important priority at LSU Health Sciences Center Shreveport (LSUHSC-S) within multiple centers and departments. Immunology as a discipline can effectively bridge many centers and departments currently on campus and thus serve as a nucleus for collaborative and synergistic research across diverse disciplines. Immunology as a discipline is now at the forefront of novel therapies to control bacterial infections, viral infections, to treat cancer; thus an expansion and growth of this area at LSUHSC-S will advance the mission of the school to grow basic science that has strong translational potential. The objective of this new COBRE Center for Applied Immunology and Pathological Processes (CAIPP) to establish an independent internationally recognized research and training program at LSUHSC-S. We propose to first mentor and develop federally funded junior faculty research and to develop new infrastructure to support the growth and continued hiring in this important area of biomedical science. Because Dr. Yurochko has 35 years of experience in immunology research, has been a junior PI in a COBRE center, Project Mentor for successful projects and part of a COBRE leadership team, he can draw on a wealth of experiences, along with those of the experienced leadership team, to drive the success of the CAIPP. Second, we propose long term to retain these immunology researchers as they become more senior through promotion, to become an international recognized research hub and to elevate the CAIPP within LSUHSC-S by becoming a state recognized Center. We shall take advantage of the strengths currently on campus and through targeted recruitment to grow the CAIPP COBRE around the focused understanding of “aberrant immune cell function and the resulting immunopathology”. The cores address critical research needs on campus and are ultimately essential for the long-term growth and status of research at LSUHSC-S. The cores build upon existing equipment and infrastructure and bring new expertise not currently available on campus; thus, they fill a needed gap in research infrastructure. Recent polling of the faculty document that all centers and most faculty (>80%) on campus will utilize/require both proposed cores to generate the needed new data for competitive national grant submissions. In summary, the major goals of this CAIPP COBRE application are to: establish a strong and consistent mentorship and professional development program that meet the individual needs of each investigator (and thus are tailored for the needs of that investigator); establish advanced research core facilities that support the university, the region and the state; advance the mechanistic and clinical understanding for how subversion of the immune response and functioning of immune cells influences human health and disease; and lastly to create an academically and financially independent and internationally recognized Center of Excellence. We support these major goals through our initial collaboration within centers and departments within the school and the entire northern region of the state and to then grow this collaboration through engagement and collaborations with colleagues in the rest of the state once we have established the foundation of the proposed CAIPP.