Center for Applied Immunology and Pathological Processes

应用免疫学和病理过程中心

• 批准号: 10360457
• 负责人: ANDREW D YUROCHKO
• 金额: $ 216.01万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10360457
• 关键词: Address; Adult; Advisory Committees; Affect; Age; Antibiotic Resistance; Antiviral resistance; Area; Arthritis; Bacterial Infections; Basic Science; Bone remodeling; Cardiovascular system; Cell Nucleus; Cell physiology; Cells; Centers of Research Excellence; Cessation of life; Chlamydia; Chronic; Clinical; Collaborations; Communicable Diseases; Core Facility; Data; Development; Discipline; Disease; Embryonic Development; Environment; Equipment; Faculty; Fostering; Foundations; Functional disorder; Funding; Future; Glare; Goals; Gonorrhea; Grant; Growth; Growth and Development function; HIV; Hand; Health; Health Sciences; Healthcare Systems; Heart Diseases; Home; Host Defense; Human; Human Resources; Hyperactivity; Immune; Immune response; Immune system; Immunology; Immunophenotyping; Immunotherapy; Individual; Infection; Infection Control; Infectious Agent; Inflammatory; Infrastructure; International; Leadership; Louisiana; Malignant Neoplasms; Mentors; Mentorship; Mission; Modeling; Molecular; Neonatal; Pathogenesis; Pathologic Processes; Pathology; Play; Process; Program Development; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Rest; Role; Schools; Science; Scientific Advances and Accomplishments; Sexually Transmitted Diseases; Site-Directed Mutagenesis; Specialist; Syphilis; Teacher Professional Development; Techniques; Therapeutic Intervention; Training; Training Programs; United States; Universities; Viral; Virus Diseases; adaptive immune response; cell growth; chronic inflammatory disease; disorder prevention; effective therapy; experience; faculty research; human disease; immune function; immunopathology; improved; insight; member; mortality; negative affect; novel therapeutics; pathogen; pathogenic bacteria; pathogenic virus; programs; recruit; response; statistics; success; synergism; tool; translational potential; tumor; wound healing

PROJECT SUMMARY/ABSTRACT A properly functioning and effective immune system is needed to control infection by bacterial, viral and other pathogen invaders, growth of aberrant cells, as well as for proper embryonic development, wound healing, bone remodeling, and other normal homeostatic processes. Thus, understanding the innate and adaptive immune responses and how abnormalities affect human health in chronic inflammatory conditions, during neonatal development and how infectious diseases and cancers subvert or alter these responses is critical to improving our health, not only in the United States, but globally. Closer to home, this unfortunately remains especially true in the state of Louisiana, which ranks near the bottom in many national health studies. For example, human immunodeficiency virus (HIV) age adjusted deaths in the state are more than double the national average, while the state ranks in the top 5 in infections with the sexually transmitted diseases, Syphilis, Gonorrhea and Chlamydia. In addition, as is documented for many states in the south, Louisiana has some of the highest rates of arthritis (affecting ~1 in 4 adults in the state), heart disease and cardiovascular deaths (ranked 46/50 and 48/50 respectively), and cancer-related mortality rates (15-20% higher than the national average) in the nation. These glaring statistics support the need for additional understanding of the pathogenesis of these diseases and new options for therapeutic interventions. One common theme among these different diseases is an aberrant immune response and resulting immunopathologies. Thus, we propose a better understanding of how aberrations in the immune system result in disease is needed. We propose that a targeted growth of an immunology-centric center on our campus at LSUHSC-S will positively influence the health of our citizens. This is especially true as new research shows targeted modifications of the immune response or immunotherapy holds great promise as an effective treatment option to control and eradicate various tumors, for the treatment and mitigation of antibiotic or antiviral resistant infectious diseases, and for the prevention of chronic inflammatory diseases, etc. Diverse research into aspects of immunology, host pathogen interactions, and the immunopathology associated with an abnormal immune response is an important priority at LSU Health Sciences Center Shreveport (LSUHSC-S) within multiple centers and departments. Immunology as a discipline can effectively bridge many centers and departments currently on campus and thus serve as a nucleus for collaborative and synergistic research across diverse disciplines. Immunology as a discipline is now at the forefront of novel therapies to control bacterial infections, viral infections, to treat cancer; thus an expansion and growth of this area at LSUHSC-S will advance the mission of the school to grow basic science that has strong translational potential. The objective of this new COBRE Center for Applied Immunology and Pathological Processes (CAIPP) to establish an independent internationally recognized research and training program at LSUHSC-S. We propose to first mentor and develop federally funded junior faculty research and to develop new infrastructure to support the growth and continued hiring in this important area of biomedical science. Because Dr. Yurochko has 35 years of experience in immunology research, has been a junior PI in a COBRE center, Project Mentor for successful projects and part of a COBRE leadership team, he can draw on a wealth of experiences, along with those of the experienced leadership team, to drive the success of the CAIPP. Second, we propose long term to retain these immunology researchers as they become more senior through promotion, to become an international recognized research hub and to elevate the CAIPP within LSUHSC-S by becoming a state recognized Center. We shall take advantage of the strengths currently on campus and through targeted recruitment to grow the CAIPP COBRE around the focused understanding of “aberrant immune cell function and the resulting immunopathology”. The cores address critical research needs on campus and are ultimately essential for the long-term growth and status of research at LSUHSC-S. The cores build upon existing equipment and infrastructure and bring new expertise not currently available on campus; thus, they fill a needed gap in research infrastructure. Recent polling of the faculty document that all centers and most faculty (>80%) on campus will utilize/require both proposed cores to generate the needed new data for competitive national grant submissions. In summary, the major goals of this CAIPP COBRE application are to: establish a strong and consistent mentorship and professional development program that meet the individual needs of each investigator (and thus are tailored for the needs of that investigator); establish advanced research core facilities that support the university, the region and the state; advance the mechanistic and clinical understanding for how subversion of the immune response and functioning of immune cells influences human health and disease; and lastly to create an academically and financially independent and internationally recognized Center of Excellence. We support these major goals through our initial collaboration within centers and departments within the school and the entire northern region of the state and to then grow this collaboration through engagement and collaborations with colleagues in the rest of the state once we have established the foundation of the proposed CAIPP.

项目概要/摘要 需要功能正常且有效的免疫系统来控制细菌、病毒和 其他病原体入侵，异常细胞的生长，以及适当的胚胎发育，伤口愈合， 骨重塑和其他正常的稳态过程。因此，了解先天性和适应性 免疫反应以及异常如何影响慢性炎症条件下的人类健康， 新生儿发育以及传染病和癌症如何颠覆或改变这些反应对于 改善我们的健康，不仅在美国，而且在全球范围内。言归正传，不幸的是，这仍然存在 在路易斯安那州尤其如此，该州在许多国家健康研究中排名接近垫底。为了 例如，该州的人类免疫缺陷病毒 (HIV) 年龄调整死亡人数是美国的两倍多 全国平均水平，而该州的性传播疾病、梅毒、 淋病和衣原体。此外，根据南部许多州的记录，路易斯安那州有一些 关节炎（影响该州约四分之一的成年人）、心脏病和心血管疾病死亡率最高 （分别排名 46/50 和 48/50）和癌症相关死亡率（比全国高 15-20%） ）全国平均水平。这些明显的统计数据支持需要进一步了解发病机制 这些疾病和治疗干预的新选择。这些不同的主题有一个共同的主题 疾病是一种异常的免疫反应和由此产生的免疫病理学。因此，我们提出一个更好的 需要了解免疫系统的异常如何导致疾病。我们建议有针对性的 LSUHSC-S 校园内以免疫学为中心的中心的发展将对我们学生的健康产生积极影响 公民。尤其是当新的研究表明免疫反应或免疫反应有针对性的改变时 免疫疗法作为控制和根除各种肿瘤的有效治疗选择具有广阔的前景 治疗和缓解抗生素或抗病毒药物耐药性传染病，以及预防 慢性炎症性疾病等。 免疫学、宿主病原体相互作用和免疫病理学方面的多样化研究 与异常免疫反应相关是路易斯安那州立大学健康科学中心的一个重要优先事项 什里夫波特 (LSUHSC-S) 设有多个中心和部门。免疫学作为一门学科可以有效地 连接目前校园内的许多中心和部门，从而成为协作和合作的核心 跨学科的协同研究。免疫学作为一门学科现在处于新颖的前沿 控制细菌感染、病毒感染、治疗癌症的疗法；从而扩大和增长这个 LSUHSC-S 领域将推进学校发展具有强大转化能力的基础科学的使命 潜在的。新 COBRE 应用免疫学和病理过程中心的目标 (CAIPP) 在以下地点建立一个独立的国际认可的研究和培训项目 路易斯安那州立大学HSC-S。我们建议首先指导和发展联邦政府资助的初级教师研究，并开发 新的基础设施支持生物医学科学这一重要领域的增长和持续招聘。 因为Yurochko博士拥有35年的免疫学研究经验，曾在COBRE担任初级PI 中心、成功项目的项目导师以及 COBRE 领导团队的一部分，他可以利用财富 丰富的经验以及经验丰富的领导团队的经验，推动 CAIPP 的成功。第二， 我们建议长期保留这些免疫学研究人员，因为他们通过晋升变得更加资深， 成为国际公认的研究中心，并通过成为 LSUHSC-S 内的 CAIPP 来提升 国家认可的中心。我们将利用校园现有的优势，通过有针对性的 围绕对“异常免疫细胞功能和 由此产生的免疫病理学”。核心解决了校园的关键研究需求，并最终 对于 LSUHSC-S 的长期发展和研究地位至关重要。核心建立在现有设备的基础上 和基础设施，并带来校园目前尚不具备的新专业知识；因此，它们填补了所需的空白 研究基础设施。最近对教师的民意调查显示，所有中心和大多数教师 (>80%) 校园将利用/需要两个拟议的核心来生成竞争性国家拨款所需的新数据 意见书。总之，CAIPP COBRE 应用程序的主要目标是： 建立一个强大且 一致的指导和专业发展计划，满足每位研究者的个人需求 （因此是根据调查员的需要量身定制的）；建立先进的研究核心设施，支持 大学、地区和国家；推进对如何颠覆的机制和临床理解 免疫反应和免疫细胞功能影响人类健康和疾病；最后到 创建一个学术和财务独立且国际认可的卓越中心。我们 通过我们在学校内的中心和部门之间的初步合作来支持这些主要目标 该州的整个北部地区，然后通过参与和合作来扩大这种合作 一旦我们为拟议的 CAIPP 奠定了基础，我们就会与该州其他地区的同事合作。