Center for Applied Immunology and Pathological Processes

应用免疫学和病理过程中心

• 批准号: 10090768
• 负责人: ANDREW D YUROCHKO
• 金额: $ 215.04万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090768
• 关键词: Address; Adult; Advisory Committees; Affect; Age; Antibiotic Resistance; Antiviral resistance; Area; Arthritis; Bacterial Infections; Basic Science; Bone remodeling; Cardiovascular system; Cell Nucleus; Cell physiology; Cells; Centers of Research Excellence; Cessation of life; Chlamydia; Chronic; Clinical; Collaborations; Communicable Diseases; Core Facility; Data; Development; Discipline; Disease; Embryonic Development; Environment; Equipment; Faculty; Fostering; Foundations; Functional disorder; Funding; Future; Glare; Goals; Gonorrhea; Grant; Growth; Growth and Development function; HIV; Hand; Health; Health Sciences; Healthcare Systems; Heart Diseases; Home; Host Defense; Human; Human Resources; Hyperactivity; Immune; Immune response; Immune system; Immunology; Immunophenotyping; Immunotherapy; Individual; Infection; Infection Control; Infectious Agent; Inflammatory; Infrastructure; International; Leadership; Louisiana; Malignant Neoplasms; Mentors; Mentorship; Mission; Modeling; Molecular; Neonatal; Pathogenesis; Pathologic Processes; Pathology; Play; Process; Program Development; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Rest; Role; Schools; Science; Scientific Advances and Accomplishments; Sexually Transmitted Diseases; Site-Directed Mutagenesis; Specialist; Syphilis; Teacher Professional Development; Techniques; Therapeutic Intervention; Training; Training Programs; United States; Universities; Viral; Virus Diseases; adaptive immune response; cell growth; chronic inflammatory disease; disorder prevention; effective therapy; experience; faculty research; human disease; immune function; immunopathology; improved; insight; member; mortality; negative affect; novel therapeutics; pathogen; pathogenic bacteria; pathogenic virus; programs; recruit; response; statistics; success; synergism; tool; tumor; wound healing

PROJECT SUMMARY/ABSTRACT A properly functioning and effective immune system is needed to control infection by bacterial, viral and other pathogen invaders, growth of aberrant cells, as well as for proper embryonic development, wound healing, bone remodeling, and other normal homeostatic processes. Thus, understanding the innate and adaptive immune responses and how abnormalities affect human health in chronic inflammatory conditions, during neonatal development and how infectious diseases and cancers subvert or alter these responses is critical to improving our health, not only in the United States, but globally. Closer to home, this unfortunately remains especially true in the state of Louisiana, which ranks near the bottom in many national health studies. For example, human immunodeficiency virus (HIV) age adjusted deaths in the state are more than double the national average, while the state ranks in the top 5 in infections with the sexually transmitted diseases, Syphilis, Gonorrhea and Chlamydia. In addition, as is documented for many states in the south, Louisiana has some of the highest rates of arthritis (affecting ~1 in 4 adults in the state), heart disease and cardiovascular deaths (ranked 46/50 and 48/50 respectively), and cancer-related mortality rates (15-20% higher than the national average) in the nation. These glaring statistics support the need for additional understanding of the pathogenesis of these diseases and new options for therapeutic interventions. One common theme among these different diseases is an aberrant immune response and resulting immunopathologies. Thus, we propose a better understanding of how aberrations in the immune system result in disease is needed. We propose that a targeted growth of an immunology-centric center on our campus at LSUHSC-S will positively influence the health of our citizens. This is especially true as new research shows targeted modifications of the immune response or immunotherapy holds great promise as an effective treatment option to control and eradicate various tumors, for the treatment and mitigation of antibiotic or antiviral resistant infectious diseases, and for the prevention of chronic inflammatory diseases, etc. Diverse research into aspects of immunology, host pathogen interactions, and the immunopathology associated with an abnormal immune response is an important priority at LSU Health Sciences Center Shreveport (LSUHSC-S) within multiple centers and departments. Immunology as a discipline can effectively bridge many centers and departments currently on campus and thus serve as a nucleus for collaborative and synergistic research across diverse disciplines. Immunology as a discipline is now at the forefront of novel therapies to control bacterial infections, viral infections, to treat cancer; thus an expansion and growth of this area at LSUHSC-S will advance the mission of the school to grow basic science that has strong translational potential. The objective of this new COBRE Center for Applied Immunology and Pathological Processes (CAIPP) to establish an independent internationally recognized research and training program at LSUHSC-S. We propose to first mentor and develop federally funded junior faculty research and to develop new infrastructure to support the growth and continued hiring in this important area of biomedical science. Because Dr. Yurochko has 35 years of experience in immunology research, has been a junior PI in a COBRE center, Project Mentor for successful projects and part of a COBRE leadership team, he can draw on a wealth of experiences, along with those of the experienced leadership team, to drive the success of the CAIPP. Second, we propose long term to retain these immunology researchers as they become more senior through promotion, to become an international recognized research hub and to elevate the CAIPP within LSUHSC-S by becoming a state recognized Center. We shall take advantage of the strengths currently on campus and through targeted recruitment to grow the CAIPP COBRE around the focused understanding of “aberrant immune cell function and the resulting immunopathology”. The cores address critical research needs on campus and are ultimately essential for the long-term growth and status of research at LSUHSC-S. The cores build upon existing equipment and infrastructure and bring new expertise not currently available on campus; thus, they fill a needed gap in research infrastructure. Recent polling of the faculty document that all centers and most faculty (>80%) on campus will utilize/require both proposed cores to generate the needed new data for competitive national grant submissions. In summary, the major goals of this CAIPP COBRE application are to: establish a strong and consistent mentorship and professional development program that meet the individual needs of each investigator (and thus are tailored for the needs of that investigator); establish advanced research core facilities that support the university, the region and the state; advance the mechanistic and clinical understanding for how subversion of the immune response and functioning of immune cells influences human health and disease; and lastly to create an academically and financially independent and internationally recognized Center of Excellence. We support these major goals through our initial collaboration within centers and departments within the school and the entire northern region of the state and to then grow this collaboration through engagement and collaborations with colleagues in the rest of the state once we have established the foundation of the proposed CAIPP.

项目总结/摘要 需要一个正常运作和有效的免疫系统来控制细菌、病毒和 其他病原体入侵者，异常细胞的生长，以及适当的胚胎发育，伤口愈合， 骨重建和其他正常的稳态过程。因此，理解先天和适应性 免疫反应和异常如何影响人类健康的慢性炎症条件下， 新生儿发育以及传染病和癌症如何破坏或改变这些反应， 改善我们的健康，不仅在美国，而且在全球。在离家更近的地方，不幸的是 路易斯安那州尤其如此，该州在许多国家健康研究中排名垫底。为 例如，该州经年龄调整的人类免疫缺陷病毒（艾滋病毒）死亡人数是2008年的两倍多。 全国平均水平，而国家排名前5位的感染性传播疾病，梅毒， 淋病和衣原体。此外，正如南部许多州的记录所示，路易斯安那州有一些 关节炎（影响该州约四分之一的成年人），心脏病和心血管疾病死亡率最高 （分别为46/50和48/50），癌症相关死亡率（比全国高15-20%） 平均值）。这些明显的统计数据支持了对发病机制的进一步理解的必要性 这些疾病和治疗干预的新选择。在这些不同的主题中， 疾病是异常的免疫应答和导致的免疫病理学。因此，我们提出了一个更好的 需要了解免疫系统中的异常如何导致疾病。我们建议有针对性地 在LSUHSC-S校园内以免疫学为中心的中心的发展将对我们的健康产生积极影响。 公民这一点尤其正确，因为新的研究表明，免疫反应的靶向修饰， 免疫疗法作为控制和根除各种肿瘤的有效治疗选择具有很大的希望， 治疗和缓解抗生素或抗病毒药物耐药性传染病，以及预防 慢性炎性疾病等。 对免疫学、宿主病原体相互作用和免疫病理学方面的不同研究 与异常免疫反应相关的疾病是路易斯安那州立大学健康科学中心的一个重要优先事项 什里夫波特（LSUHSC-S）在多个中心和部门。免疫学作为一门学科， 连接目前校园内的许多中心和部门，从而成为协作和 跨学科的协同研究。免疫学作为一门学科，现在处于新的前沿。 控制细菌感染，病毒感染，治疗癌症的治疗方法;因此，这一领域的扩大和发展， LSUHSC-S的一个区域将推进学校的使命，以发展具有强大转化能力的基础科学。 潜力这个新的COBRE应用免疫学和病理过程中心的目标是 （CAIPP）建立一个独立的国际公认的研究和培训计划， LSUHSC-S。我们建议首先指导和发展联邦资助的初级教师研究， 新的基础设施，以支持生物医学科学这一重要领域的增长和持续招聘。 因为Yurochko博士有35年的免疫学研究经验，一直是COBRE的初级PI 中心，成功项目的项目导师和COBRE领导团队的一部分，他可以利用财富 经验的积累，沿着经验丰富的领导团队，推动CAIPP的成功。第二、 我们建议长期保留这些免疫学研究人员，因为他们通过晋升变得更高级， 成为国际公认的研究中心，并通过成为LSUHSC-S提升CAIPP 国家认可的中心。我们将利用目前在校园的优势，并通过有针对性的 招募围绕“异常免疫细胞功能和 产生的免疫病理学”。这些核心解决了校园内的关键研究需求， 这对LSUHSC-S的长期发展和研究状况至关重要。核心是建立在现有的设备上 和基础设施，并带来新的专业知识，目前没有在校园;因此，他们填补了一个必要的差距， 研究基础设施。最近对教师的民意调查表明，所有中心和大多数教师（>80%） 校园将利用/需要两个拟议的核心，以产生所需的新数据，为竞争性的国家赠款 意见书。总之，该CAIPP COBRE应用程序的主要目标是：建立一个强大且 一致的指导和专业发展计划，满足每个研究者的个人需求 (and因此，根据研究者的需要量身定制）;建立先进的研究核心设施， 大学、地区和国家;推进对颠覆如何进行的机械和临床理解 免疫反应和免疫细胞的功能影响人类健康和疾病;最后， 创建一个学术和财务独立和国际公认的卓越中心。我们 通过我们在学校内的中心和部门之间的初步合作来支持这些主要目标， 整个州的北方地区，然后通过参与和合作来发展这种合作 一旦我们建立了拟议的CAIPP的基础，我们将与该州其他地区的同事一起工作。