Translation and Validation of a Radiofrequency-Penetrable PET insert for Simultaneous PET/MRI imaging of Neurological Disorders

用于神经系统疾病同步 PET/MRI 成像的射频可穿透 PET 插入物的转化和验证

• 批准号: 10365492
• 负责人: CRAIG S LEVIN
• 金额: $ 61.79万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-03 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10365492
• 关键词: Address; Adherence; Adoption; Agreement; Alzheimer' s Disease; Alzheimer' s disease pathology; Amyloid; Anatomy; Attenuated; Biological Markers; Brain; Breast; Caliber; Clinic; Clinical; Coiled Bodies; Collection; Computer software; Data; Data Set; Development; Digital Imaging and Communications in Medicine; Disease; Engineering; Ensure; Exhibits; FDA approved; Generations; Head; Head and neck structure; Image; Impaired cognition; Industry; Industry Collaboration; Industry Standard; Institution; Ionizing radiation; Liver; Machine Learning; Magnetic Resonance Imaging; Measurement; Methods; Modality; Modeling; Modification; Motion; National Institute on Aging; Nerve Degeneration; Neurodegenerative Disorders; Patients; Pelvis; Performance; Phase; Photons; Positron-Emission Tomography; Radiation; Radiation Dose Unit; Research; Resolution; Scanning; Standardization; Study Subject; System; Technology; Translating; Translations; Validation; Vendor; Work; base; clinical translation; comparative; computerized data processing; cost; data acquisition; data standards; design; disease classification; graphical user interface; image reconstruction; imaging study; imaging system; improved; industry partner; innovation; ionization; nervous system disorder; neuroimaging; new technology; novel; pediatric patients; radio frequency; soft tissue; software development; stem; tau Proteins; tau aggregation; translational study; transmission process

Project Summary/Abstract We propose the clinical translation and validation of an innovative “radiofrequency (RF) penetrable” dedicated positron emission tomography (PET) insert technology that can be placed within any stand- alone magnetic resonance imaging (MRI) system for acquiring simultaneous PET/MRI data. For this proposal the Stanford team will work with industry partner “PETcoil” to address technical developments required for translational studies, ensure industry level standardization of end user software and technology, and acquire first in-patient simultaneous PET/MRI data using this novel PET insert. PET/MRI exhibits some attractive features. First, combined PET/MRI is uniquely capable of providing excellent anatomical soft tissue contrast and multi-parameter information in a single a scan and, as a result, PET/MR is now commonly used for characterizing disease in regions such as the brain, head and neck, breast, liver and pelvis. Second, MRI does not introduce ionization radiation in a PET/MR study. This significant reduction of radiation dose makes PET/MRI an attractive modality for pediatric patients and those requiring recurring PET studies. Third, PET/MR imaging can occur simultaneously, unlike sequential PET/CT, resulting in temporal in addition to spatial correlation of PET with MR data. Despite these attractive features, the adoption of PET/MRI has been slow since its introduction in 2011. One main reason for this slow adoption is the high cost of procuring an integrated PET/MRI system, which is about $5M for the machine and another $1.5–2M for required room renovations to host the machine. The resulting cost (~$6-7M) is simply not affordable for most institutions. Furthermore, the permanently integrated PET/MR system designs offered by vendors such as GE and Siemens yield sub-optimal spatial resolution and sensitivity performance for the PET system component, especially for neurological imaging applications. The proposed brain-dedicated PET ring offers higher photon sensitivity and spatial resolution, and can be inserted into any existing MR system; thus a user only needs to procure the insert, and MR system modifications or room renovations are not required, reducing the entry costs roughly 10- fold. We have realized a 1st generation brain dedicated PET insert for simultaneous PET/MR and are completing a 2nd generation version, both with a spatial resolution of 2.7x2.7x2.7 mm3 and the latter achieving a photon sensitivity of >6%. In addition, this insert approach is “RF penetrable,” an important and novel concept enabling collection of PET/MR data using the MR system’s built-in body coil for RF transmission through the PET ring insert into the patient, and only a RF receiver coil resides inside the insert, thus facilitating the lower cost insert concept for achieving PET/MR. We will translate and validate the 2nd generation brain PET insert and work with our industry partner to standardize our data processing workflow. If successful, this project will enable more widespread dissemination/accessibility of PET/MRI.

项目摘要/摘要 我们提出了创新的“射频（RF）可渗透”的临床翻译和验证 专用的正电子发射断层扫描（PET）插入技术可以放置在任何独立的 单独的磁共振成像（MRI）系统，用于同时获得PET/MRI数据。为了这 提案Stanford团队将与行业合作伙伴“ Petcoil”合作，以解决技术发展 翻译研究所需的需要，确保最终用户软件的行业级别标准化和 技术，并使用这款新颖的PET插入物获得了首次接受住院简单的PET/MRI数据。宠物/MRI 表现出一些吸引人的功能。首先，组合的宠物/MRI具有独特的能力 单个A扫描中的解剖学软组织对比和多参数信息，因此， PET/MR现在通常用于表征大脑，头颈等地区的疾病 乳房，肝脏和骨盆。其次，MRI不会在PET/MR研究中引入电离辐射。这 辐射剂量的显着降低使PET/MRI成为儿科患者的吸引人方式，并且 那些需要经常出现的宠物研究的人。第三，可以简单地发生宠物/MR成像 顺序PET/CT，除了PET与MR数据的空间相关性外，还导致暂时性。尽管 这些有吸引力的功能，自2011年推出以来，宠物/MRI的采用一直很慢。 采用这种缓慢采用的原因是采购集成的宠物/MRI系统的高昂成本，这是关于 这台机器的$ 500万美元，另外15-20万美元用于托管机器所需的房间装修。这 对于大多数机构而言，最终成本（约6-700万美元）根本无法负担。此外，永久性 GE和西门子等供应商提供的综合宠物/MR系统设计产生了次优的空间 宠物系统成分的分辨率和灵敏度性能，尤其是神经成像 申请。提出的脑诊断宠物环具有较高的光子灵敏度和空间 解决方案，可以插入任何现有的MR系统；因此，用户只需要采购插入物， 不需要MR系统修改或房间翻新，降低入口成本约为10- 折叠。我们已经意识到了第一个专门用于简单宠物/MR的大脑专用宠物插入物，并且是 完成第二代版本，既有空间分辨率为2.7x2.7x2.7mm3 and the the the swiment 达到> 6％的光子灵敏度。此外，这种插入方法是“ RF可渗透”，这是一个重要的 和新颖的概念，可以使用MR System的内置身体线圈收集PET/MR数据 通过PET环插入患者，只有RF接收器线圈在该患者中 插入物，从而支持较低的成本插入概念以实现宠物/MR。我们将翻译和验证 第二代脑宠物插入物和与我们的行业合作伙伴合作以标准化数据处理 工作流程。如果成功，该项目将使PET/MRI的更多宽度传播/可访问性。