Exploring concepts in nanophotonics and metamaterials to create a 'super-scintillator' for time-of-flight positron emission tomography
探索纳米光子学和超材料概念,创建用于飞行时间正电子发射断层扫描的“超级闪烁体”
基本信息
- 批准号:10685592
- 负责人:
- 金额:$ 19.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-17 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdoptedBiodistributionBiologicalBiological MarkersBiologyBismuthCell physiologyCellsChemicalsChemistryClinicClinicalContrast MediaDatabasesDetectionDiagnostic Neoplasm StagingDiameterDiseaseDisease ManagementDisease PathwayDoseElectromagnetic EnergyElectromagnetic FieldsElectromagneticsElectronsElementsEnhancing LesionEventFluoridesGeometryGoalsHeart DiseasesImageImage EnhancementImaging technologyInvestigationLabelLesionLightLocationMalignant NeoplasmsMeasurementMeasuresMedical ImagingMethodsModalityMolecularMolecular ProfilingMonitorNanostructuresNoiseOperative Surgical ProceduresOpticsPatientsPerformancePhotonsPlanet EarthPositioning AttributePositronPositron-Emission TomographyProceduresPropertyPublishingRadiation therapyRadioactiveRadioisotopesRadiolabeledRecurrenceResearchResolutionRoleScanningShapesSignal TransductionSystemTechniquesTechnologyThree-Dimensional ImageTimeTracerVisible RadiationVisualizationWorkabsorptionbiomedical imagingcancer therapycostcrystallinitydesigndetection sensitivitydetectorfabricationimage reconstructionimprovedmultidisciplinarynanocompositenanofabricationnanomaterialsnanoparticlenanophotonicnervous system disordernew technologynovelnovel diagnosticsnovel therapeuticspatient safetyphoton-counting detectorphotonicsresponseself assemblysimulationstandard of carethree-dimensional visualizationtooltransmission processtwo-photon
项目摘要
Abstract
Positron emission tomography (PET) is a standard of care to molecularly characterize cancer and heart disease.
It is also a well-used research tool to visualize and quantify molecular pathways of disease in neurological
disorders. We propose to develop a metamaterial to create a “super-scintillator” for time-of-flight (ToF) PET. If
successful, this technology will substantially enhance the image quality and quantitative accuracy of PET and
open new roles for the modality in the management of disease. PET employs a radiolabeled molecular contrast
agent that is injected into the patient to probe the biological mechanisms of disease. This tracer accumulates in
the cells that express certain molecular signatures, enabling 3-dimensional visualization and quantification of
disease biomarkers. The tracer molecule is labeled by a positron emitter that for every decay results in the
emission of two oppositely directed 511 kilo-electron-volt (keV) annihilation photons. ToF-PET uses the arrival
time difference between the two photons in each pair to more accurately position the emission location along
PET system detector response lines, enhancing the reconstructed image signal-to-noise ratio (RISNR). RISNR
is an image quality metric that strongly correlates with lesion detection sensitivity and accuracy. The more precise
this time difference measurement, known as the coincidence time resolution (CTR), the better the RISNR. Any
boosts in RISNR can also be employed to reduce injected radioactive dose or scanning duration, increasing
patient safety or throughput in the clinic, respectively. The long-term goal for the proposed new scintillation
technology is <10 picosecond (ps) CTR, which is over 20-fold better than the best CTR (214 ps) achieved for a
state-of-the-art clinical ToF-PET system, enabling ~5-fold higher RISNR or ~25-fold lower injected dose or scan
time compared to that system. If successful, this capability would enable new applications for PET. Current PET
systems employ scintillation crystals, which are materials that convert 511 keV photon interactions in the crystal
into flashes of visible light. We propose to use nanophotonic techniques to create a metamaterial “super”
scintillator with vastly shorter rise time and decay time and greater light yield than all known PET scintillators,
enabling the >20-fold reduction in CTR proposed. The emergence of nanophotonics and metamaterials has
revolutionized photonics. Nanostructured materials provide considerable control over internal electromagnetic
fields, enabling highly unusual optical properties not found in standard materials. This exciting investigation will
have tremendous impact by both introducing a new technology, metamaterials, to the field of biomedical imaging,
and by achieving breakthrough performance levels in PET imaging, that, if successful, will greatly expand PET’s
capabilities for characterizing disease, as well as enable new roles for PET in disease management.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CRAIG S LEVIN其他文献
CRAIG S LEVIN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CRAIG S LEVIN', 18)}}的其他基金
Exploring concepts in nanophotonics and metamaterials to create a 'super-scintillator' for time-of-flight positron emission tomography
探索纳米光子学和超材料概念,创建用于飞行时间正电子发射断层扫描的“超级闪烁体”
- 批准号:
10509318 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Translation and Validation of a Radiofrequency-Penetrable PET insert for Simultaneous PET/MRI imaging of Neurological Disorders
用于神经系统疾病同步 PET/MRI 成像的射频可穿透 PET 插入物的转化和验证
- 批准号:
10616704 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Translation and Validation of a Radiofrequency-Penetrable PET insert for Simultaneous PET/MRI imaging of Neurological Disorders
用于神经系统疾病同步 PET/MRI 成像的射频可穿透 PET 插入物的转化和验证
- 批准号:
10365492 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
RF-penetrable PET ring for acquiring simultaneous time-of-flight PET and MRI data
可穿透射频的 PET 环,用于同时采集飞行时间 PET 和 MRI 数据
- 批准号:
10268119 - 财政年份:2020
- 资助金额:
$ 19.68万 - 项目类别:
Technologies to drastically boost photon sensitivity for brain-dedicated PET
大幅提高大脑专用 PET 光子灵敏度的技术
- 批准号:
9420111 - 财政年份:2017
- 资助金额:
$ 19.68万 - 项目类别:
A new direction to achieve ultra-fast timing for positron emission tomography
实现正电子发射断层扫描超快定时的新方向
- 批准号:
9444922 - 财政年份:2017
- 资助金额:
$ 19.68万 - 项目类别:
Exploring a promising design for the next generation time-of-flight PET detector
探索下一代飞行时间 PET 探测器的有前途的设计
- 批准号:
10171564 - 财政年份:2017
- 资助金额:
$ 19.68万 - 项目类别:
Exploring a promising design for the next generation time-of-flight PET detector
探索下一代飞行时间 PET 探测器的有前途的设计
- 批准号:
9918874 - 财政年份:2017
- 资助金额:
$ 19.68万 - 项目类别:
Technologies to drastically boost photon sensitivity for brain-dedicated PET
大幅提高大脑专用 PET 光子灵敏度的技术
- 批准号:
9568754 - 财政年份:2017
- 资助金额:
$ 19.68万 - 项目类别:
Stanford Molecular Imaging Scholars (SMIS) Program
斯坦福大学分子成像学者 (SMIS) 计划
- 批准号:
10410895 - 财政年份:2016
- 资助金额:
$ 19.68万 - 项目类别:
相似海外基金
Targeted Delivery of Biodistribution-Guided Recombinant Adeno-associated Viral Vector (AAV) to Specific Hepatocytes
将生物分布引导的重组腺相关病毒载体 (AAV) 靶向递送至特定肝细胞
- 批准号:
24K18551 - 财政年份:2024
- 资助金额:
$ 19.68万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Remote control of nanoparticle biodistribution
纳米粒子生物分布的远程控制
- 批准号:
571918-2022 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Alliance Grants
Examining the role of LDLR in the biodistribution of carotenoids
检查 LDLR 在类胡萝卜素生物分布中的作用
- 批准号:
10709514 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Examining the role of LDLR in the biodistribution of carotenoids
检查 LDLR 在类胡萝卜素生物分布中的作用
- 批准号:
10534613 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Assessing the Dosimetry and Biodistribution of Actinium-225 for Targeted Alpha Therapy
评估 Actinium-225 用于靶向 Alpha 治疗的剂量测定和生物分布
- 批准号:
547302-2020 - 财政年份:2022
- 资助金额:
$ 19.68万 - 项目类别:
Postgraduate Scholarships - Doctoral
Assessing the Dosimetry and Biodistribution of Actinium-225 for Targeted Alpha Therapy
评估 Actinium-225 用于靶向 Alpha 治疗的剂量测定和生物分布
- 批准号:
547302-2020 - 财政年份:2021
- 资助金额:
$ 19.68万 - 项目类别:
Postgraduate Scholarships - Doctoral
Larve de l'insecte Chaoborus comme biomoniteur de contamination en terres rares : utilité, biodistribution et gestion subcellulaire
Chaoborus 幼虫对稀有陆地污染的生物监测:利用、生物分布和亚细胞妊娠
- 批准号:
565723-2021 - 财政年份:2021
- 资助金额:
$ 19.68万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Biodistribution, dépuration et internalisation des éléments traces métalliques chez Chaoborus
元素的生物分布、净化和内化可追溯至 Chaoborus 的 métalliques
- 批准号:
550614-2020 - 财政年份:2020
- 资助金额:
$ 19.68万 - 项目类别:
University Undergraduate Student Research Awards
Development of bioorthogonal stimulated Raman scattering microscopy for evaluation of drug biodistribution
开发用于评估药物生物分布的生物正交受激拉曼散射显微镜
- 批准号:
2424285 - 财政年份:2020
- 资助金额:
$ 19.68万 - 项目类别:
Studentship
Biodistribution and PK modeling of rat vs. human systems
大鼠与人体系统的生物分布和 PK 建模
- 批准号:
10359139 - 财政年份:2020
- 资助金额:
$ 19.68万 - 项目类别:














{{item.name}}会员




