Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes

昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用

基本信息

  • 批准号:
    10364620
  • 负责人:
  • 金额:
    $ 41.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-02-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT It is reported that 1/3rd of Americans have bedtimes after midnight, which may increase risk for cardiometabolic disease due to misalignment of the sleep period relative to the internal circadian rhythm and short sleep duration. Given the relationship between circadian alignment and disruptions in eating behaviors and insulin resistance, this study will build on our previous work by examining the neurobehavioral and dietary mechanisms that link late sleep to increased cardiometabolic risk. There is strong evidence that late sleep timing is associated with individual differences in neurobehavioral processes, such reduced ability to delay gratification and impulsivity. We propose a model in which circadian misalignment affects neurobehavioral processes and eating behaviors that increase cardiometabolic risk. In this model, exposure to short sleep duration is a moderator of these relationships. A limitation of previous research on circadian alignment is that most have been conducted as short term experiments in highly controlled laboratory settings and little attention has been paid to behavioral mechanisms. Therefore, the overarching goal of our research is to elucidate the behavioral and biological mechanisms of cardiometabolic risk among individuals with late sleep timing living under naturalistic conditions. We will to test our model of neurobehavioral vulnerability among late sleepers in a 12-month longitudinal study of 100 overweight or obese adults with late sleep timing (bedtime at 12:00 am or later). Participants will complete metabolic, sleep, diet and circadian assessments at baseline, 6 and 12 months. We will conduct neurobehavioral and eating assessments in the morning and evening to evaluate the role of time of day in neurobehavioral and eating behaviors. The aims of this study are 1. To determine the role of circadian alignment with and without short sleep duration on neurobehavioral processes, dietary behaviors and cardiometabolic risk factors, 2. To determine if time of day impacts neurobehavioral measures and dietary behaviors among overweight individuals with late sleep timing, and 3. To determine how circadian misalignment predicts changes in cardiometabolic risk over 12 months. We will test neurobehavioral measures and sleep duration as moderators of the effects of circadian misalignment in longitudinal models. Results of this study will advance knowledge of the complex relationship between sleep/circadian rhythms and cardiometabolic risk in terms of both biological and behavioral contributors, thus providing the basis for new behavioral and environmental interventions targeted to align circadian rhythms and modify neurobehavioral processes among individuals with late sleep timing.
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Kelly Glazer Baron其他文献

Kelly Glazer Baron的其他文献

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{{ truncateString('Kelly Glazer Baron', 18)}}的其他基金

Addressing sleep health disparities from within: A community-engaged study to understanding sleep and cardiometabolic disease risk among women of color
从内部解决睡眠健康差异:一项社区参与的研究,旨在了解有色人种女性的睡眠和心脏代谢疾病风险
  • 批准号:
    10815470
  • 财政年份:
    2023
  • 资助金额:
    $ 41.08万
  • 项目类别:
Dyadic Sleep, Biobehavioral Rhythms and Cognitive Function in Older Adults: Implications for Alzheimer’s Disease
老年人的二元睡眠、生物行为节律和认知功能:对阿尔茨海默病的影响
  • 批准号:
    10584241
  • 财政年份:
    2023
  • 资助金额:
    $ 41.08万
  • 项目类别:
Effects of behavioral sleep extension on Alzheimers disease relevant blood biomarkers and cognitive performance
行为睡眠延长对阿尔茨海默病相关血液生物标志物和认知能力的影响
  • 批准号:
    10288146
  • 财政年份:
    2021
  • 资助金额:
    $ 41.08万
  • 项目类别:
Mixed Methods Evaluation of a Couples-Based Treatment to Improve CPAP Adherence and Sleep Health Among Patients with Obstructive Sleep Apnea and Increased Risk for Alzheimer's Disease
混合方法评估以夫妻为基础的治疗方法,以改善阻塞性睡眠呼吸暂停和阿尔茨海默病风险增加患者的 CPAP 依从性和睡眠健康
  • 批准号:
    10339141
  • 财政年份:
    2020
  • 资助金额:
    $ 41.08万
  • 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
  • 批准号:
    10271243
  • 财政年份:
    2020
  • 资助金额:
    $ 41.08万
  • 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
  • 批准号:
    10627801
  • 财政年份:
    2020
  • 资助金额:
    $ 41.08万
  • 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
  • 批准号:
    10438889
  • 财政年份:
    2020
  • 资助金额:
    $ 41.08万
  • 项目类别:
Sleep, circadian rhythms: associations with diabetes risk and mood
睡眠、昼夜节律:与糖尿病风险和情绪的关联
  • 批准号:
    10683676
  • 财政年份:
    2019
  • 资助金额:
    $ 41.08万
  • 项目类别:
Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes
昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用
  • 批准号:
    10545057
  • 财政年份:
    2019
  • 资助金额:
    $ 41.08万
  • 项目类别:
Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes
昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用
  • 批准号:
    10078973
  • 财政年份:
    2019
  • 资助金额:
    $ 41.08万
  • 项目类别:

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