Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes
昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用
基本信息
- 批准号:10078973
- 负责人:
- 金额:$ 45.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAmericanAttentionBedsBehaviorBehavior TherapyBehavioralBehavioral MechanismsBiologicalBody CompositionBody fatBody mass indexCardiometabolic DiseaseCessation of lifeCircadian RhythmsCircadian desynchronyComplexCross-Sectional StudiesDesire for foodDiabetes MellitusDietEatingEating BehaviorEnergy IntakeEnergy MetabolismEnvironmentExposure toFoodFrequenciesFutureGlucose tolerance testGlycosylated hemoglobin AGoalsHormonesHourImpulsivityIndividualIndividual DifferencesInsulin ResistanceInterventionKnowledgeLaboratoriesLightLinkLongitudinal StudiesLongitudinal observational studyMeasuresMelatoninMetabolicMetabolismModelingObesityOutcomeOverweightParticipantPathway interactionsPhaseProcessReportingResearchResearch DesignRestRewardsRisk FactorsRoleSamplingSleepStandardizationTestingTimeWeight GainWorkadult obesitybasecardiometabolic riskcircadiandiabetes riskdietarydisabilitydiscountingdisorder riskeating in absence of hungerenvironmental interventionexperimental studyfollow up assessmenthigh body mass indexinsulin sensitivityinterestneurobehavioralneurobehavioral testobesity developmentobesity riskpreferenceprematureprospectivesleep onset
项目摘要
PROJECT SUMMARY/ABSTRACT
It is reported that 1/3rd of Americans have bedtimes after midnight, which may increase risk for
cardiometabolic disease due to misalignment of the sleep period relative to the internal
circadian rhythm and short sleep duration. Given the relationship between circadian alignment
and disruptions in eating behaviors and insulin resistance, this study will build on our previous
work by examining the neurobehavioral and dietary mechanisms that link late sleep to increased
cardiometabolic risk. There is strong evidence that late sleep timing is associated with individual
differences in neurobehavioral processes, such reduced ability to delay gratification and
impulsivity. We propose a model in which circadian misalignment affects neurobehavioral
processes and eating behaviors that increase cardiometabolic risk. In this model, exposure to
short sleep duration is a moderator of these relationships. A limitation of previous research on
circadian alignment is that most have been conducted as short term experiments in highly
controlled laboratory settings and little attention has been paid to behavioral mechanisms.
Therefore, the overarching goal of our research is to elucidate the behavioral and biological
mechanisms of cardiometabolic risk among individuals with late sleep timing living under
naturalistic conditions. We will to test our model of neurobehavioral vulnerability among late
sleepers in a 12-month longitudinal study of 100 overweight or obese adults with late sleep
timing (bedtime at 12:00 am or later). Participants will complete metabolic, sleep, diet and
circadian assessments at baseline, 6 and 12 months. We will conduct neurobehavioral and
eating assessments in the morning and evening to evaluate the role of time of day in
neurobehavioral and eating behaviors. The aims of this study are 1. To determine the role of
circadian alignment with and without short sleep duration on neurobehavioral processes,
dietary behaviors and cardiometabolic risk factors, 2. To determine if time of day impacts
neurobehavioral measures and dietary behaviors among overweight individuals with late
sleep timing, and 3. To determine how circadian misalignment predicts changes in
cardiometabolic risk over 12 months. We will test neurobehavioral measures and sleep
duration as moderators of the effects of circadian misalignment in longitudinal models. Results
of this study will advance knowledge of the complex relationship between sleep/circadian
rhythms and cardiometabolic risk in terms of both biological and behavioral contributors, thus
providing the basis for new behavioral and environmental interventions targeted to align
circadian rhythms and modify neurobehavioral processes among individuals with late sleep
timing.
项目总结/摘要
据报道,三分之一的美国人在午夜后睡觉,这可能会增加患上糖尿病的风险。
由于睡眠时间相对于内部代谢的不对准而引起的心脏代谢疾病
昼夜节律和睡眠时间短。考虑到生物钟排列
以及饮食行为和胰岛素抵抗的中断,这项研究将建立在我们以前的基础上。
通过检查将晚睡与睡眠增加联系起来的神经行为和饮食机制来工作
心脏代谢风险。有强有力的证据表明,晚睡时间与个人
神经行为过程的差异,如延迟满足的能力降低,
冲动我们提出了一个昼夜节律失调影响神经行为的模型
增加心脏代谢风险的过程和饮食行为。在这个模型中,
睡眠时间短是这些关系的调节剂。以往研究的局限性
昼夜节律的调整是,大多数已经进行了短期实验,在高度
控制实验室设置和很少注意到行为机制。
因此,我们研究的首要目标是阐明行为和生物学
睡眠时间较晚的人的心脏代谢风险机制
自然条件。我们将测试我们的神经行为脆弱性模型,
对100名超重或肥胖的晚睡成年人进行了为期12个月的纵向研究
定时(12:00或更晚就寝)。参与者将完成代谢,睡眠,饮食和
基线、6个月和12个月的昼夜节律评估。我们将进行神经行为和
在早上和晚上进行进食评估,以评估一天中的时间在
神经行为和饮食行为。本研究的目的是1。确定的作用
在短睡眠时间和不短睡眠时间的情况下对神经行为过程的昼夜节律调整,
饮食行为和心脏代谢危险因素,2.为了确定一天中的时间是否会影响
神经行为测量和饮食行为的超重个体与晚
睡眠时间,以及3.为了确定昼夜节律失调如何预测
心脏代谢风险超过12个月。我们将测试神经行为指标和睡眠
持续时间作为纵向模型中昼夜节律失调影响的调节因子。结果
这项研究的结果将进一步了解睡眠/昼夜节律之间的复杂关系,
节律和心脏代谢风险的生物和行为的贡献者,因此,
为新的行为和环境干预措施提供基础,
昼夜节律和修改神经行为过程中的个人与晚睡
时机
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kelly Glazer Baron其他文献
Kelly Glazer Baron的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kelly Glazer Baron', 18)}}的其他基金
Addressing sleep health disparities from within: A community-engaged study to understanding sleep and cardiometabolic disease risk among women of color
从内部解决睡眠健康差异:一项社区参与的研究,旨在了解有色人种女性的睡眠和心脏代谢疾病风险
- 批准号:
10815470 - 财政年份:2023
- 资助金额:
$ 45.65万 - 项目类别:
Dyadic Sleep, Biobehavioral Rhythms and Cognitive Function in Older Adults: Implications for Alzheimer’s Disease
老年人的二元睡眠、生物行为节律和认知功能:对阿尔茨海默病的影响
- 批准号:
10584241 - 财政年份:2023
- 资助金额:
$ 45.65万 - 项目类别:
Effects of behavioral sleep extension on Alzheimers disease relevant blood biomarkers and cognitive performance
行为睡眠延长对阿尔茨海默病相关血液生物标志物和认知能力的影响
- 批准号:
10288146 - 财政年份:2021
- 资助金额:
$ 45.65万 - 项目类别:
Mixed Methods Evaluation of a Couples-Based Treatment to Improve CPAP Adherence and Sleep Health Among Patients with Obstructive Sleep Apnea and Increased Risk for Alzheimer's Disease
混合方法评估以夫妻为基础的治疗方法,以改善阻塞性睡眠呼吸暂停和阿尔茨海默病风险增加患者的 CPAP 依从性和睡眠健康
- 批准号:
10339141 - 财政年份:2020
- 资助金额:
$ 45.65万 - 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
- 批准号:
10271243 - 财政年份:2020
- 资助金额:
$ 45.65万 - 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
- 批准号:
10627801 - 财政年份:2020
- 资助金额:
$ 45.65万 - 项目类别:
Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension
行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响
- 批准号:
10438889 - 财政年份:2020
- 资助金额:
$ 45.65万 - 项目类别:
Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes
昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用
- 批准号:
10364620 - 财政年份:2019
- 资助金额:
$ 45.65万 - 项目类别:
Sleep, circadian rhythms: associations with diabetes risk and mood
睡眠、昼夜节律:与糖尿病风险和情绪的关联
- 批准号:
10683676 - 财政年份:2019
- 资助金额:
$ 45.65万 - 项目类别:
Circadian and sleep pathways to cardiometabolic disease risk: role of neurobehavioral processes
昼夜节律和睡眠途径对心脏代谢疾病风险的影响:神经行为过程的作用
- 批准号:
10545057 - 财政年份:2019
- 资助金额:
$ 45.65万 - 项目类别:
相似海外基金
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348998 - 财政年份:2025
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348999 - 财政年份:2025
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Collaborative Research: Ionospheric Density Response to American Solar Eclipses Using Coordinated Radio Observations with Modeling Support
合作研究:利用协调射电观测和建模支持对美国日食的电离层密度响应
- 批准号:
2412294 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Conference: Doctoral Consortium at Student Research Workshop at the Annual Conference of the North American Chapter of the Association for Computational Linguistics (NAACL)
会议:计算语言学协会 (NAACL) 北美分会年会学生研究研讨会上的博士联盟
- 批准号:
2415059 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Conference: Polymeric Materials: Science and Engineering Division Centennial Celebration at the Spring 2024 American Chemical Society Meeting
会议:高分子材料:美国化学会 2024 年春季会议科学与工程部百年庆典
- 批准号:
2415569 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Continental-Scale Study of Jura-Cretaceous Basins and Melanges along the Backbone of the North American Cordillera-A Test of Mesozoic Subduction Models
合作研究:RUI:北美科迪勒拉山脊沿线汝拉-白垩纪盆地和混杂岩的大陆尺度研究——中生代俯冲模型的检验
- 批准号:
2346565 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
REU Site: Research Experiences for American Leadership of Industry with Zero Emissions by 2050 (REALIZE-2050)
REU 网站:2050 年美国零排放工业领先地位的研究经验 (REALIZE-2050)
- 批准号:
2349580 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Continental-Scale Study of Jura-Cretaceous Basins and Melanges along the Backbone of the North American Cordillera-A Test of Mesozoic Subduction Models
合作研究:RUI:北美科迪勒拉山脊沿线汝拉-白垩纪盆地和混杂岩的大陆尺度研究——中生代俯冲模型的检验
- 批准号:
2346564 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Conference: Latin American School of Algebraic Geometry
会议:拉丁美洲代数几何学院
- 批准号:
2401164 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant
Conference: North American High Order Methods Con (NAHOMCon)
会议:北美高阶方法大会 (NAHOMCon)
- 批准号:
2333724 - 财政年份:2024
- 资助金额:
$ 45.65万 - 项目类别:
Standard Grant