Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension

项目摘要/摘要 在美国，每两个成年人中就有一个至少患有一种心脏代谢性疾病(CMD)，包括高血压、心脏病 疾病、糖尿病或中风。尽管睡眠时间短与心脏代谢健康之间存在联系，但很少有人 研究试图通过延长睡眠时间来降低患CMD的风险。睡眠延长是一个很有前途的研究领域。 干预措施。到目前为止，一些小规模的研究已经证明了睡眠和CMD的短期改善。 危险因素，如血压和血糖控制。然而，这些研究因其短小而受到限制。 术语设计和将延长睡眠视为一种实验性操作而不是可持续的行为 变化。在这项研究中，我们建议进行一项随机对照试验来测试我们的行为睡眠 扩展干预与健康教育对照组在睡眠和CMD危险因素方面的比较 患有高血压前期/I期高血压的成年人。睡眠延长干预以3口井为基础 既定的行为改变原则：自我监控(可穿戴式睡眠跟踪器)、教育(电子邮件内容) 和激励增强(简短的电话辅导)。在这项为期12个月的研究中，我们将包括 干预期(1-8周，每周干预)，维护期(2-6个月，每月干预) 随访期(无干预)。这项研究的主要结果将是睡眠时间和主要 次要结果将是24小时动态血压监测，这使我们能够评估两者 日常生活中白天和夜间的血压。12个月睡眠时间变化的评价 将使我们能够测试我们的行为睡眠延长干预对急性和持续性的疗效 睡眠时间和CMD危险因素的变化以及重要的心理、行为和 生理调节因素，如自我报告的困倦、体重指数、饮食、体力活动、血糖控制和 发炎。这项研究的成功完成将提供有关以下影响的关键信息 纳入睡眠所需的健康和生活质量重要指标的行为睡眠延长 推广到CMD风险干预措施，如饮食和体力活动计划。这样做的长期目标是 研究是开发、测试和传播有效的、可扩展的睡眠干预措施，以减少慢性 疾病风险和改善疾病管理。

PROJECT SUMMARY/ABSTRACT One in two adults in the U.S. have at least one cardiometabolic disease (CMD) including hypertension, heart disease diabetes or stroke. Despite links between short sleep duration and cardiometabolic health, few studies have sought to improve CMD risk by extending sleep. A promising area of research is sleep extension interventions. To date, several small studies have demonstrated short term improvements in sleep and CMD risk factors such as blood pressure and glycemic control. However, these studies are limited by their short term design and viewing sleep extension as an experimental manipulation rather than a sustainable behavior change. In this study, we are proposing to conduct a randomized controlled trial to test our behavioral sleep extension intervention compared to a health education control group on sleep and CMD risk factors among adults with prehypertension/stage I hypertension. The sleep extension intervention is based on 3 well established behavior change principles: self-monitoring (wearable sleep tracker), education (email content) and motivational enhancement (brief telephone coaching). During this 12 month study, we will include an intervention period (weeks 1-8, weekly intervention), maintenance period (months 2-6, monthly intervention) and follow-up period (no intervention). The primary outcome for this study will be sleep duration and the main secondary outcome will be 24-h ambulatory blood pressure monitoring, which allows us to evaluate both daytime and nighttime blood pressures in daily life. The evaluation of sleep duration changes of 12-months will allow us to test the efficacy of our behavioral sleep extension intervention on acute and sustained changes in sleep duration and CMD risk factors as well as important psychological, behavioral and physiological mediators such as self-reported sleepiness, BMI, diet, physical activity, glycemic control and inflammation. Successful completion of this study will provide critical information about the impact of behavioral sleep extension on important measures of health and quality of life needed to incorporate sleep extension into CMD risk interventions, such as diet and physical activity programs. The long-term goal of this research is to develop, test and disseminate effective and scalable sleep interventions to reduce chronic disease risk and improve disease management.