North Carolina Translational and Clinical Science Institute (NC TraCS) TL1

J.培训核心摘要 协作的跨学科团队对于实现和翻译高影响力的科学至关重要，但多个领域 为了实现这一目标， 的翻译。为了减少翻译效率的障碍，需要创新的培训计划， 培养一批具有跨翻译连续体“讲语言”技能的研究人员。UNC 拥有资源和承诺，以制定创新战略，以解决这一关键的培训 需要的这支新兴的翻译研究队伍将成为关键的团队成员和领导者， 目前各学科和环境之间的差距，调整不同学科的方法和办法， 将其纳入研究，并与广泛的利益相关者进行有效沟通。我们认为， 三个核心里程碑对于生物医学发现的转化至关重要：（1）将发现通过 商业化/创业的过程;（2）评估临床试验中的产品;（3） 将新发现或循证实践纳入综合卫生系统。 我们提出了一个新的TL 1博士后培训计划，重点是在其中一个特定的轨道沉浸 三个翻译主题我们选择了这个节目中的曲目，因为它们符合 TraCS和NIH的目标。我们将利用现有的计划和专业知识，包括TraCS， 卡罗莱纳健康信息学项目（CHIP）和计算生物学项目，临床试验 基础设施，我们的合作伙伴关系的企业商业化的新查佩尔山技术，和 医疗保健系统。经验丰富的培训核心领导团队将加入：（1）教师 具有科学和/或临床内容专业知识的导师，以进一步翻译此产品或想法，（2） 资源专家，其主要职责是操作翻译，以及（3）特定学科 信息学专家，他们可以指导受训者了解与其项目相关的信息学方法和资源。 我们的总体目标是：培养一批希望成为翻译科学家的博士后研究员， 让他们沉浸在翻译管道中三个轨道之一的研究产品的翻译中- 临床试验，商业化和创业，或卫生系统。我们将通过以下方式实现这一目标：（1） 为研究员提供教学和体验式培训，以发展和应用目标领域的技能， 成为翻译研究团队的领导者和有效成员，以及（2）增加保留 通过促进研究员过渡到个人研究培训奖，就业或 其他适当的研究支持机制。 有效的翻译是一项“团队运动”，我们的目标是创造一个培训环境， 科学与翻译所需的有效操作相结合。这项培训将使TL 1研究员做好准备， 作为跨翻译管道的领导者，可以合并和管理未来的团队。

J. Training Core Abstract Collaborative interdisciplinary teams are critical to achieve and translate high impact science, yet multiple fields of expertise, each having its own language and culture, must be integrated and coordinated to achieve the goal of translation. To diminish barriers to translational efficiency, innovative training programs are needed to develop a cadre of researchers with the skills to `speak the language' across the translational continuum. UNC possesses the resources and commitment to develop innovative strategies to address this critical training need. This emerging translational research workforce will become key team members and leaders who bridge current divides across disciplines and setting, adapt methods and approaches from different disciplines and integrate them into research, and effectively communicate with a broad group of stakeholders. In our view, three core milestones are central to the translation of biomedical discoveries: (1) moving discoveries through the process of commercialization/entrepreneurship; (2) evaluating products in clinical trials; and (3) bringing discoveries or evidence-based practices into integrated health systems. We propose a new TL1 postdoctoral training program focused toward track-specific immersion in one of these three translational themes. We have chosen the tracks in this program because they are in alignment with the goals of TraCS and the NIH. We will leverage existing programs and expertise including those of TraCS, the Carolina Health Informatics Program (CHIP) and Computational Biology programs, the clinical trials infrastructure, our Partnership for Entrepreneurial Commercialization of UNC Chapel Hill Technology, and the UNC Health Care System. The experienced Training Core Leadership Team will be joined by: (1) faculty mentors who have the scientific and/or clinical content expertise to further translate this product or idea, (2) resource experts whose primary responsibilities are to operationalize translation, and (3) discipline-specific informatics experts who can direct the trainee to informatics methods and resources relevant to their project. Our overarching goal is: to train a cadre of postdoctoral fellows who wish to become translational scientists by immersing them in the translation of research products within one of three tracks in the translational pipeline— clinical trials, commercialization and entrepreneurship, or health systems. We will accomplish this goal by: (1) providing fellows with the didactic and experiential training to develop and apply skills in their targeted area to become leaders and effective members of translational research teams, and (2) increasing retention in translational science by facilitating transition of fellows to individual research training awards, employment or other appropriate mechanisms of research support. Effective translation is a “team sport”, and our goal is to create a training environment that includes the best science coupled with effective operationalization required for translation. This training will prepare TL1 fellows to serve as leaders across the translational pipeline who can both coalesce and manage future teams.