North Carolina Translational and Clinical Science Institute (NC TraCS) TL1

J.培训核心摘要 协作的跨学科团队是实现和转化具有高度影响力的科学的关键，但涉及多个领域 为了实现这一目标，必须整合和协调各种专业知识，每种专业知识都有自己的语言和文化 翻译的问题。为了减少翻译效率的障碍，需要创新的培训计划来 培养一支有能力在整个翻译过程中“说这种语言”的研究人员队伍。北卡罗来纳大学 拥有资源并致力于制定创新战略来解决这一关键培训问题 需要。这支新兴的翻译研究队伍将成为搭建桥梁的关键团队成员和领导者 当前跨学科和背景的划分，采用不同学科和 将它们整合到研究中，并有效地与广泛的利益相关者群体进行沟通。在我们看来， 三个核心里程碑是生物医学发现转化的核心：(1)通过 商业化/创业的过程；(2)在临床试验中评估产品；以及(3)带来 将新发现或循证实践纳入综合卫生系统。 我们提出了一个新的TL1博士后培训计划，专注于其中之一的轨迹特定沉浸 三个翻译主题。我们之所以选择这个节目中的赛道，是因为它们与 TraCS和NIH的目标。我们将利用现有的计划和专业知识，包括TraCS、 卡罗莱纳健康信息学计划(CHIP)和计算生物学计划，临床试验 基础设施，我们的北卡罗来纳大学教堂山技术企业商业化伙伴关系，以及 北卡罗来纳大学医疗保健系统。经验丰富的培训核心领导团队将加入：(1)教职员工 具有科学和/或临床内容专业知识以进一步翻译本产品或想法的导师，(2) 主要负责实施翻译的资源专家，以及(3)特定学科 信息学专家，他们可以指导学员使用与其项目相关的信息学方法和资源。 我们的总体目标是：培养一批希望在以下方面成为翻译科学家的博士后 让他们沉浸在翻译管道中的三个轨道之一的研究产品的翻译中- 临床试验、商业化和创业，或卫生系统。我们将通过以下方式实现这一目标：(一) 为研究员提供教学和体验式培训，以发展和应用其目标领域的技能 成为翻译研究团队的领导者和有效成员，以及(2)提高在 通过促进研究员向个人研究培训奖、就业或 其他适当的研究支持机制。 有效的翻译是一项团队运动，我们的目标是创造一个包括最好的翻译的培训环境 科学加上有效的可操作性是翻译所必需的。该培训将为TL1研究员做好准备 作为翻译渠道的领导者，既能联合起来，又能管理未来的团队。

J. Training Core Abstract Collaborative interdisciplinary teams are critical to achieve and translate high impact science, yet multiple fields of expertise, each having its own language and culture, must be integrated and coordinated to achieve the goal of translation. To diminish barriers to translational efficiency, innovative training programs are needed to develop a cadre of researchers with the skills to `speak the language' across the translational continuum. UNC possesses the resources and commitment to develop innovative strategies to address this critical training need. This emerging translational research workforce will become key team members and leaders who bridge current divides across disciplines and setting, adapt methods and approaches from different disciplines and integrate them into research, and effectively communicate with a broad group of stakeholders. In our view, three core milestones are central to the translation of biomedical discoveries: (1) moving discoveries through the process of commercialization/entrepreneurship; (2) evaluating products in clinical trials; and (3) bringing discoveries or evidence-based practices into integrated health systems. We propose a new TL1 postdoctoral training program focused toward track-specific immersion in one of these three translational themes. We have chosen the tracks in this program because they are in alignment with the goals of TraCS and the NIH. We will leverage existing programs and expertise including those of TraCS, the Carolina Health Informatics Program (CHIP) and Computational Biology programs, the clinical trials infrastructure, our Partnership for Entrepreneurial Commercialization of UNC Chapel Hill Technology, and the UNC Health Care System. The experienced Training Core Leadership Team will be joined by: (1) faculty mentors who have the scientific and/or clinical content expertise to further translate this product or idea, (2) resource experts whose primary responsibilities are to operationalize translation, and (3) discipline-specific informatics experts who can direct the trainee to informatics methods and resources relevant to their project. Our overarching goal is: to train a cadre of postdoctoral fellows who wish to become translational scientists by immersing them in the translation of research products within one of three tracks in the translational pipeline— clinical trials, commercialization and entrepreneurship, or health systems. We will accomplish this goal by: (1) providing fellows with the didactic and experiential training to develop and apply skills in their targeted area to become leaders and effective members of translational research teams, and (2) increasing retention in translational science by facilitating transition of fellows to individual research training awards, employment or other appropriate mechanisms of research support. Effective translation is a “team sport”, and our goal is to create a training environment that includes the best science coupled with effective operationalization required for translation. This training will prepare TL1 fellows to serve as leaders across the translational pipeline who can both coalesce and manage future teams.