HELical Biodegradable Photochemical(HELP)Stents for AVF Maturation
HELical Biodegradable Photochemical(HELP)Stents for AVF Maturation
批准号:
9202757
负责人:
PRABIR ROY-CHAUDHURY
金额:
$27.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-15 至 2021-06-30
关键词:
Absorbable ImplantsAchievementAddressAnimalsArteriovenous fistulaBiodegradationBiologyBlood VesselsBlood flowCaliberCaringCathetersCellsChemicalsClinicalDialysis procedureDrug Delivery SystemsEndothelial CellsEngineeringFailureFamily suidaeFunctional disorderFutureGenerationsGenesHemodialysisHyperplasiaIn VitroInfectionInflammationLegal patentMagnesiumMedicineModelingMorbidity - disease rateNamesOperative Surgical ProceduresOutcomeOxidative StressPatient-Focused OutcomesPatientsPharmaceutical PreparationsPhysiologicalPredispositionProductionRiskSeriesSmall Business Technology Transfer ResearchStenosisStentsSystemTechnologyTestingTherapeuticThrombosisTimeToxic effectTreatment EfficacyUremiaVeinsVenousbasebiomaterial compatibilitycostcost effectivedesigneconomic costeffective therapyhemodynamicsimprovedin vivoinnovationinnovative technologiesinterestnovelnovel therapeuticspreventprogramsresearch studyscale upshear stresssystemic toxicity
中文摘要
摘要
英文摘要
ABSTRACT
Although arteriovenous fistulae (AVFs) are the preferred mode of dialysis vascular access, over 50% fail to
“mature”, in that they do not develop an adequate blood flow or diameter to support hemodialysis. This results
in a very significant clinical morbidity and economic cost. At a pathogenetic level, AVF maturation failure is due
to (a) small vessels (b) “bad” non-laminar hemodynamic profiles that likely result in a more aggressive
stenosis, due to endothelial cell dysfunction and (c) abnormal baseline vascular biology due to uremia and
oxidative stress.
The central hypothesis for this proposal is that the placement of a HELical biodegradable Photochemically
etched (HELP) stent at the time of AVF creation will (a) dilate small veins (b) create “good” hemodynamics
through the generation of spiral laminar flow (c) have the future potential to optimize “local uremic vascular
biology” through selected coatings (drugs, cells or chemicals), and so “help” with AVF maturation.
We plan to address this central hypothesis through a series of specific aims that focus on (a) fabrication of
HELP stents that have an optimized flow profile in-vitro (Specific Aim 1 = Engineering Aim) (b) demonstration
of in-vivo degradation and toxicity profiles (Specific Aim 2 = Biocompatibility and Toxicity Aim) (c) in-vivo proof
of principle experiments to document therapeutic efficacy (flow and diameter; Specific Aim 3 = Therapeutic
Aim).
In summary, there is clearly a huge and unmet clinical need for novel therapies to enhance AVF maturation
(there are currently no effective therapies for this). In addition, the innovative photochemical technology
described in this proposal lends itself to mass production and subsequent economies of scale. As a result we
strongly believe that the HELP stent is an important platform technology that could deliver improved patient
outcomes at reduced cost, thus adding overall value to the care of hemodialysis patients.
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TRIO Professional Development Core
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依托单位:
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批准号:9918649
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财政年份:2020
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依托单位:
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财政年份:2018
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依托单位:
North Carolina Translational and Clinical Science Institute (NC TraCS) TL1
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批准号:10364744
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财政年份:2018
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依托单位:
Localized Delivery of Sirolimus to Hemodialysis Vascular Access Grafts
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批准号:10017609
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项目类别:
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资助金额:$19.4万
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财政年份:2017
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
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批准号:8635063
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项目类别:
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资助金额:$0.0万
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财政年份:2013
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
A luminal vascular coating to reduce time to maturation and failures of AV-Fistulas for hemodialysis access
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批准号:8906287
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项目类别:
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资助金额:$85.08万
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财政年份:2013
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Hemodynamics, Uremia & Vascular Biology: Interactive Pathways for AVF Maturation
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批准号:9223568
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项目类别:
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资助金额:$0.0万
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财政年份:2013
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Hemodynamics, Uremia & Vascular Biology: Interactive Pathways for AVF Maturation
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批准号:8966673
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项目类别:
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资助金额:$0.0万
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财政年份:2013
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依托单位:
Biodegradable Magensium Stents to Enhance AV Fistula Maturation
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财政年份:2012
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依托单位:
Biodegradable Magensium Stents to Enhance AV Fistula Maturation
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项目类别:
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财政年份:2012
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Real Time Nitric Oxide Measurements as a Determinant of AV Fistula Maturation
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项目类别:
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财政年份:2010
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Real Time Nitric Oxide Measurements as a Determinant of AV Fistula Maturation
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批准号:7976550
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项目类别:
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资助金额:$23.23万
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财政年份:2010
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Clinical, Hemodynamic and Biological Markers of AV Fistula Maturation
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批准号:7899525
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项目类别:
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资助金额:$34.97万
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财政年份:2009
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Clinical, Hemodynamic and Biological Markers of AV Fistula Maturation
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批准号:8137098
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项目类别:
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资助金额:$34.49万
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财政年份:2008
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Clinical, Hemodynamic and Biological Markers of AV Fistula Maturation
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批准号:7923347
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项目类别:
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资助金额:$34.51万
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财政年份:2008
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
Clinical, Hemodynamic and Biological Markers of AV Fistula Maturation
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资助金额:$34.71万
-
财政年份:2008
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负责人:PRABIR ROY-CHAUDHURY
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依托单位:
海外基金