Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

项目总结 酒精使用障碍(AUD)研究通常简单地分析复发和康复过程 时间范围，例如在治疗期间和紧接着治疗发作之后。它的长期发展轨迹 康复、复发发作的影响及其相关的神经行为标志物和沉淀物 这构成了我们对恢复进程的科学理解中的一个重大差距。我们的目标是提供一个 对康复和复发的科学理解，以及确定未来复发的新目标 预防干预措施。具体地说，将使用以下方法调查AUD基础机制的变化 竞争性神经行为决策系统(CNDS)框架，它假设成瘾和复发 产生于冲动决策系统和执行决策系统之间的监管失衡。为了追求这一目标， 患有澳元的参与者将从国际戒烟与恢复登记处(IQRR)招募，该登记处曾 成立于2011年，目前约有8775名注册者。IQRR提供了一个独特的在线资源 这使得能够对恢复过程进行科学研究，并高效地收集适合于 长期重复测量研究。我们将使用加速纵向设计，这将允许 12年来心理社会功能、复发和CNDS功能的前瞻性特征 通过招募一系列不同恢复时间的参与者进行澳元恢复，最长可达10年。超过三个人 在未来几年内，参与者将完成季度评估，包括衡量CNDS的运作情况。在目标1中，我们 我将研究AUD长期康复期间的心理社会功能，以及CNDS对其的影响 监管。在目标2中，我们将检查长期AUD恢复过程中的复发以及CNDS对复发的影响 监管。在目标3中，我们将研究影响恢复的CNDS流程的动态交互作用 计算建模。总而言之，这一严谨而创新的研究项目的结果将会得到改善 我们对澳门氏症恢复的时间动力学和潜在机制的理解。

PROJECT SUMMARY Alcohol use disorder (AUD) research typically analyzes relapse and recovery processes over short time-frames, such as during and immediately following a treatment episode. The long-term trajectories of recovery, the impact of relapse episodes, and their associated neurobehavioral markers and precipitants comprise a vital gap in our scientific understanding of the recovery process. Our goals are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions. Specifically, changes in the mechanisms underlying AUD will be investigated using the Competing Neurobehavioral Decision Systems (CNDS) framework, which posits that addiction and relapse arise from a regulatory imbalance between the impulsive and executive decision systems. To pursue this goal, participants with AUD will be recruited from the International Quit & Recovery Registry (IQRR), which was established in 2011 and currently has about 8,775 registrants. The IQRR provides a unique online resource that permits the scientific study of recovery processes and the highly efficient collection of data suitable for long-term repeated measurement research. We will use an accelerated longitudinal design, which allows the prospective characterization of psychosocial functioning, relapse, and CNDS functioning across 12 years of AUD recovery by recruiting participants with a range of different recovery lengths, up to 10 years. Over three years, participants will complete quarterly assessments, including measures of CNDS functioning. In Aim 1, we will examine the psychosocial functioning over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 2, we will examine relapse over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 3 we will examine the dynamic interaction of CNDS processes impacting the recovery using computational modeling. Together, the findings from this rigorous and innovative research project will improve our understanding of the temporal dynamics and underlying mechanisms of recovery from AUD.