Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

项目摘要 酒精使用障碍（AUD）研究通常在短期内分析复发和恢复过程 时间范围，例如在治疗事件期间和紧接治疗事件之后。长期的发展轨迹 恢复，复发事件的影响，以及相关的神经行为标志物和促发因素 构成了我们对复苏过程的科学理解中的一个重要空白。我们的目标是提供一个 对康复和复发的科学理解，以及确定未来复发的新目标 预防干预。具体而言，AUD潜在机制的变化将使用 竞争神经行为决策系统（CNDS）框架，该框架假定成瘾和复发 产生于冲动和执行决策系统之间的调节失衡。为了实现这一目标， AUD参与者将从国际戒烟与恢复登记处（IQRR）招募，该登记处 成立于2011年，目前约有8，775名注册人。IQRR提供独特的在线资源 这允许对恢复过程进行科学研究，并高效收集适合于 长期重复测量研究。我们将采用加速纵向设计， 12年的社会心理功能、复发和CNDS功能的前瞻性表征 通过招募具有不同恢复长度（最长10年）的参与者来恢复澳元。超过三 2010年，参与者将完成季度评估，包括国家安全理事会运作的措施。目标1： 将研究澳元长期复苏过程中的社会心理功能以及CNDS对其的影响 调控在目标2中，我们将研究澳元长期复苏过程中的复发以及CNDS对其的影响 调控在目标3中，我们将研究CNDS过程的动态相互作用对恢复的影响， 计算建模总之，这个严谨而创新的研究项目的结果将改善 我们对AUD恢复的时间动态和潜在机制的理解。

PROJECT SUMMARY Alcohol use disorder (AUD) research typically analyzes relapse and recovery processes over short time-frames, such as during and immediately following a treatment episode. The long-term trajectories of recovery, the impact of relapse episodes, and their associated neurobehavioral markers and precipitants comprise a vital gap in our scientific understanding of the recovery process. Our goals are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions. Specifically, changes in the mechanisms underlying AUD will be investigated using the Competing Neurobehavioral Decision Systems (CNDS) framework, which posits that addiction and relapse arise from a regulatory imbalance between the impulsive and executive decision systems. To pursue this goal, participants with AUD will be recruited from the International Quit & Recovery Registry (IQRR), which was established in 2011 and currently has about 8,775 registrants. The IQRR provides a unique online resource that permits the scientific study of recovery processes and the highly efficient collection of data suitable for long-term repeated measurement research. We will use an accelerated longitudinal design, which allows the prospective characterization of psychosocial functioning, relapse, and CNDS functioning across 12 years of AUD recovery by recruiting participants with a range of different recovery lengths, up to 10 years. Over three years, participants will complete quarterly assessments, including measures of CNDS functioning. In Aim 1, we will examine the psychosocial functioning over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 2, we will examine relapse over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 3 we will examine the dynamic interaction of CNDS processes impacting the recovery using computational modeling. Together, the findings from this rigorous and innovative research project will improve our understanding of the temporal dynamics and underlying mechanisms of recovery from AUD.