Project 3: The abuse liability and substitution profile of removing cigarette ventilation in the experimental tobacco marketplace

项目 3：实验烟草市场中去除卷烟通风的滥用倾向和替代概况

• 批准号: 10246920
• 负责人: Warren K Bickel
• 金额: $ 36.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246920
• 关键词: Address; Adult; Affect; Alternative Nicotine Delivery Systems; Animals; Biological Markers; Cigarette; Complement; Complex; Consumption; Data; Economics; Elasticity; Electronic cigarette; Environment; Exposure to; Gender; Goals; Grant; Health; Light; Long-Term Effects; Lung Adenocarcinoma; Mainstreaming; Measures; Methods; Modeling; Nicotine; Palate; Participant; Policies; Price; Public Health; Regulation; Research; Risk; Series; Smoke; Smokeless Tobacco; Smoker; Smoking; Taste Perception; Testing; Tobacco; Tobacco Industry; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; authority; behavioral economics; cigarette smoke; deprivation; design; evidence base; experience; non-cigarette tobacco product; preference; prospective; tobacco products; ventilation

ABSTRACT Cigarette filter ventilation is a major design feature of the majority of cigarettes sold in the United States and abroad. Although filter ventilation was initially intended to produce a lighter tasting and potentially safer cigarette by diluting mainstream cigarette smoke, data have since suggested that ventilation instead increases total harm from smoking by inducing compensatory smoking (e.g., increased puff volume and/or more cigarettes smoked per day due to reduced nicotine yields) and may increase cigarette abuse liability (addictive potential). The goal of this project is to use the recently developed Experimental Tobacco Marketplace to assess the effects of removing filter ventilation, thereby modeling a regulatory environment in which filter ventilation was banned, on behavioral economic measures of abuse liability. In a series of studies featuring both between- and within-subject design components, the research team will compare purchasing and consumption of unventilated and ventilated cigarettes across a broad range of prices, as well as examine how filter ventilation impacts the degree to which an array of alternative nicotine delivery systems (e.g., electronic cigarettes, smokeless tobacco) serve as economic substitutes for cigarettes. Moreover, we will model electronic cigarette regulatory restrictions on flavor and available nicotine concentrations to examine how such restrictions interact with cigarette filter ventilation to affect tobacco consumption. Together, the findings from this project could be used to inform and maximize the efficacy of regulatory action regarding cigarette filter ventilation and alternative nicotine delivery systems.

摘要 香烟过滤嘴通风是在美国销售的大多数香烟的主要设计特征 国内外虽然过滤通风最初是为了产生一个较轻的口味， 更安全的香烟稀释主流香烟烟雾，数据表明， 而是通过诱导补偿性吸烟（例如，增加抽吸 由于尼古丁产量减少，每天吸烟量和/或吸烟量增加）， 香烟滥用倾向（成瘾潜力）。该项目的目标是使用最近开发的 实验烟草市场评估去除过滤器通风的影响，从而建模 一个监管环境中，过滤通风被禁止，对行为经济措施， 滥用责任在一系列以受试者间和受试者内设计组件为特征的研究中， 研究小组将比较不通风和通风香烟的购买和消费 在广泛的价格范围内，以及检查过滤器通风如何影响 一系列可供选择的尼古丁输送系统（例如，电子香烟、无烟烟草）作为 香烟的经济替代品。此外，我们将模拟电子烟监管限制 研究这些限制如何与香烟相互作用， 过滤器通风影响烟草消费。总之，该项目的研究结果可用于 通知和最大限度地提高有关香烟过滤嘴通风和替代品的监管行动的效力 尼古丁输送系统。