ARBi - Assessment and Rehabilitation of Binocular Sensorimotor Disorders
ARBi - 双眼感觉运动障碍的评估和康复
基本信息
- 批准号:10366392
- 负责人:
- 金额:$ 59.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAdultAffectAmblyopiaAsthenopiaAttentionBasic ScienceBehaviorBehavioralBinocular VisionBlindnessClutteringsComplexCustomDataDepth PerceptionDevelopmentDevicesDiplopiaDiseaseEducationEffectivenessEnvironmentEsotropiaEvaluationExotropiaEyeEye MovementsFailureFeedbackFoundationsGaitGoalsHeadHead MovementsHealthImageImpairmentInterventionLaboratoriesLeadLifeMaintenanceMeasurementMeasuresMethodologyMethodsMonitorMonocular VisionMotorOccupationsOperative Surgical ProceduresOutcomePatientsPerceptionPerformancePersonsPosturePrevalencePsychophysicsPublic HealthQuality of lifeReadingRehabilitation therapyResearchRetinaRiskSensorimotor functionsSensorySportsStimulusStimulus Deprivation-Induced AmblyopiaStrabismusStructureSyndromeSystemTechnologyTherapeuticTimeTrainingTranslatingVisionVisualVisual FieldsVisual impairmentVisual system structureWalkingbaseclinical practicecommercializationcomputer frameworkcritical perioddigitalevidence basegazegraspimprovedinnovationmonocularmotor controlmotor deficitmotor impairmentmotor rehabilitationmovienoveloculomotoroculomotor behaviorpersonalized medicinepreservationpreventrecidivismremediationsample fixationsensory inputsensory mechanismsensory systemside effectsocioeconomicsstandard carestatisticsstereoscopicsuccesssynergismtargeted treatmenttreatment responsevirtualvirtual realityvisual dysfunctionvisual performancevisual tracking
项目摘要
PROJECT SUMMARY
Binocular vision relies on a synergy between sensory and motor fusional mechanisms that jointly construct a
single percept of the environment from the differing images formed on the two retinae. A stereoscopic sensory
representation of the environment is required for accurate binocular eye movements, which in turn are required
for stereoscopic sensory vision. A failure in either component of this system, especially during development, can
lead to permanent binocular vision impairment. Sensory impairments can include amblyopia, diplopia and
suppression, oculomotor impairments can include strabismus and vergence insufficiency, while socio-economic
sequelae include lost education, sport and job opportunities and elevated adverse health risks. The current
treatments for amblyopia (occlusion and penalization) are primarily monocular and do not promote binocular
perception or eye movement coordination. Similarly, treatments for strabismus do not typically address binocular
perception. These limitations are at least partly due to a lack of practical methodologies for the assessment of
sensory-motor function and partly due to a lack of coordinated sensory-motor therapies.
Recent data show that there is significant plasticity in both sensory systems and motor systems, even in adults.
Many groups are now exploring methods to promote sensory plasticity with digitally modified images in
dichoptic games and movies, but considerably less attention has been directed to motor plasticity or sensory
and motor plasticity together. We hypothesize that additional therapeutic gains and a lower risk of adverse side
effects may be achieved with a combined sensory-motor therapeutic approach that is monitored by effective
sensory-motor endpoints. We argue i) that the pace of commercialization of virtual reality therapies for
anisometropic amblyopia intensifies the need simultaneously to understand sensory and oculomotor deficits in
strabismic amblyopia and ii) that the high levels of recidivism following surgical intervention may benefit from
combined sensorimotor rehabilitation. In Aim 1, we develop and evaluate efficient methods to measure sensory
and motor deficits in people with binocular vision impairment and to provide a quantitative framework for
evidence-based assessment of sensory-motor therapy. In Aim 2, we measure the impact across the visual field
of strabismus on the three-dimensional representation of virtual and natural environments to understand how
the distribution of naturally occurring depth statistics across the visual field may impact the development of
binocular sensory and motor deficits and moderate their response to treatment. In Aim 3, we develop and
evaluate feedback-based methods that aim to facilitate and maintain ocular alignment and examine the
potential benefit of simultaneous sensory and motor interventions for binocular visual function. In each Aim, we
employ both laboratory stimuli, because of their high level of control, and natural and virtual 3D scenes,
because of their rich structure and relevance to real-world deficits. The overall goal is to demonstrate the
theoretical foundation for combined sensory and motor therapeutic approaches to binocular visual dysfunction.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARTIN S BANKS其他文献
MARTIN S BANKS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARTIN S BANKS', 18)}}的其他基金
A New Approach to Restoring Visual Acuity and Stereopsis in Adults with Amblyopia
恢复成人弱视患者视力和立体视觉的新方法
- 批准号:
10047179 - 财政年份:2010
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
6794034 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
6936515 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
7922276 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
8073465 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
7466717 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
6521945 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
6658194 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
Improvements in 3D Visualization for Vision Research
视觉研究 3D 可视化的改进
- 批准号:
7826604 - 财政年份:2002
- 资助金额:
$ 59.49万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 59.49万 - 项目类别:
Research Grant