Data Management, Biostatistics & Bioinformatics Core D

数据管理、生物统计学

• 批准号: 10373919
• 负责人: Sharon Xiangwen Xie
• 金额: $ 45.27万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373919
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Bioinformatics; Biological Markers; Biometry; Clinical; Collaborations; Computer Systems; Computer software; Cytoplasmic Inclusion; Data; Data Analyses; Databases; Dementia with Lewy Bodies; Development; Disease Progression; Fostering; Generations; Genetic; Genetic Markers; Goals; Grant; Health Policy; Image; Impaired cognition; Lead; Lewy Bodies; Lewy Body Disease; Lewy neurites; Manuscripts; Medical Genetics; Methodology; Multiple System Atrophy; National Institute on Aging; Neurons; Parkinson Disease; Parkinson' s Dementia; Pathologic; Pathology; Pennsylvania; Play; Preparation; Procedures; Publications; Quality Control; Questionnaire Designs; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Role; Sample Size; Security; Services; Site; Statistical Methods; Training; United States National Institutes of Health; Universities; Yang; alpha synuclein; austin; data management; data quality; data sharing; genetic analysis; medical schools; multimodality; neuropathology; next generation; operation; programs; relational database; risk prediction model; statistics; support network; synucleinopathy; white matter

Core D: Data Management, Biostatistics and Bioinformatics Core Core Leader: Sharon X. Xie; Co-Investigator: Li-San Wang Summary/Abstract: Data Management, Biostatistics and Bioinformatics Core D The Data Management, Biostatistics and Bioinformatics Core D is an integral part of this National on Aging (NIA) U19 “Center On Alpha-synuclein Strains In Alzheimer Disease & Related Dementias” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core D is to support the data management, database, statistics, bioinformatics, and related computational needs of Penn U19 Center investigators, as well as provide data sharing support to investigators outside the U19 Center and Penn. The services provided by Core D include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn U19 Center activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Center, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the Center data, (d) integration of bioinformatics and biostatistics expertise to support analysis of genetic data and development of multimodal risk prediction models, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of Center data, (f) Implementation of data sharing between the U19 Center and other researchers outside the U19 Center and Penn in partnership with the NIA. Thus, Core D plays an important and significant role that is critical to the progress of research and the conduct of studies in the Penn U19 Center, and it will foster collaborative interactions between the Penn U19 Center and researchers outside the Center.

核心 D：数据管理、生物统计学和生物信息学核心 核心负责人：谢晓霞；联合研究员：王立三 摘要/摘要：数据管理、生物统计学和生物信息学核心 D 数据管理、生物统计学和生物信息学核心 D 是国家老龄化计划的组成部分 (NIA) U19 “阿尔茨海默病及相关痴呆症中的 α-突触核蛋白菌株中心” 宾夕法尼亚州 (Penn) 佩雷尔曼医学院 (PSOM)。 Core D 的目标是支持数据 Penn U19 中心的管理、数据库、统计、生物信息学和相关计算需求 调查人员，并为 U19 中心和宾夕法尼亚大学以外的调查人员提供数据共享支持。这 核心 D 提供的服务包括： (a) 对数据表格/调查问卷设计和开发的支持， 数据库开发和管理、数据录入、数据库审计跟踪、数据库安全、数据库备份、 和严格的数据质量控制程序，(b) 为所有宾夕法尼亚大学 U19 中心提供计算和编程支持 活动，包括数据所需的硬件和软件升级的实施和集成 中心计算系统的管理和研究、例行和档案异地备份，(c) 为项目和核心从开始到出版的所有研究方面提供生物统计支持，包括 开发研究设计、执行样本量和功效计算以及执行分析 中心数据，(d) 整合生物信息学和生物统计学专业知识，支持遗传数据分析和 开发多模式风险预测模型，(e) 开发新的统计方法和 在需要分析中心数据时扩展现有方法， (f) 数据的实施 U19 中心与 U19 中心和宾夕法尼亚大学以外的其他研究人员之间的共享 国家情报局。因此，Core D 起着重要且显着的作用，对于研究的进展和研究的进展至关重要。 在宾夕法尼亚大学 U19 中心进行研究，它将促进宾夕法尼亚大学 U19 之间的合作互动 中心和中心外的研究人员。