Data Management, Biostatistics & Bioinformatics Core D

数据管理、生物统计学

• 批准号: 10020333
• 负责人: Sharon Xiangwen Xie
• 金额: $ 50.07万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10020333
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Bioinformatics; Biological Markers; Biometry; Clinical; Collaborations; Computer Systems; Computer software; Cytoplasmic Inclusion; Data; Data Analyses; Databases; Development; Disease Progression; Fostering; Generations; Genetic; Genetic Markers; Goals; Grant; Health Policy; Image; Impaired cognition; Lead; Lewy Bodies; Lewy Body Dementia; Lewy Body Disease; Lewy neurites; Manuscripts; Medical Genetics; Methodology; Multiple System Atrophy; National Institute on Aging; Neurons; Parkinson Disease; Parkinson' s Dementia; Pathologic; Pathology; Pennsylvania; Play; Preparation; Procedures; Publications; Quality Control; Questionnaire Designs; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Role; Sample Size; Security; Services; Site; Statistical Methods; Training; United States National Institutes of Health; Universities; Yang; alpha synuclein; austin; data management; data quality; data sharing; genetic analysis; medical schools; multimodality; neuropathology; next generation; operation; programs; relational database; risk prediction model; statistics; support network; synucleinopathy; white matter

Core D: Data Management, Biostatistics and Bioinformatics Core Core Leader: Sharon X. Xie; Co-Investigator: Li-San Wang Summary/Abstract: Data Management, Biostatistics and Bioinformatics Core D The Data Management, Biostatistics and Bioinformatics Core D is an integral part of this National on Aging (NIA) U19 “Center On Alpha-synuclein Strains In Alzheimer Disease & Related Dementias” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core D is to support the data management, database, statistics, bioinformatics, and related computational needs of Penn U19 Center investigators, as well as provide data sharing support to investigators outside the U19 Center and Penn. The services provided by Core D include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn U19 Center activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Center, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the Center data, (d) integration of bioinformatics and biostatistics expertise to support analysis of genetic data and development of multimodal risk prediction models, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of Center data, (f) Implementation of data sharing between the U19 Center and other researchers outside the U19 Center and Penn in partnership with the NIA. Thus, Core D plays an important and significant role that is critical to the progress of research and the conduct of studies in the Penn U19 Center, and it will foster collaborative interactions between the Penn U19 Center and researchers outside the Center.

核心D：数据管理，生物统计学和生物信息学核心