BIOSTATISTIC AND DATA MANAGEMENT CORE

项目概要：这里的生物统计学和数据管理核心（Core E）提案是计划项目资助（PPG）申请的一部分，旨在阐明遗传性和散发性额颞叶痴呆（FTD）或额颞叶变性（FTLD）的脑变性机制。该核心支持所有数据管理、统计和计算需求，并维护PPG数据库，以获取该PPG内所有核心和项目1-4的患者导向研究数据。的 提供的服务包括：（a）支持数据表格/调查表的设计和开发、数据库开发和管理、数据输入、数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序;（B）为所有PPG活动提供计算和编程支持，包括数据管理和研究所需的硬件和软件升级的实施和整合，以及计算系统的常规和归档异地备份 PPG的核心，包括PPG数据库;（c）从研究开始到发表的所有研究方面的生物统计支持，包括研究设计的开发、样本量和把握度计算、随机化方案以及PPG数据分析;以及（d）在数据分析需要时开发新的统计方法。因此，核心E发挥着重要和显著的作用，这对研究进展和本PPG研究的开展至关重要。本核心中提出的研究与本PPG中其他核心和所有4个项目中进行的补充研究一起，将有助于更好地了解FTLD伴tau病理学和FTLD伴TDP-43病理学的神经退行性机制，这可能会加强为这些疾病开发更好的诊断和治疗干预措施的努力。

PROJECT SUMMARY: The Biostatistics and Data Management Core (Core E) proposal here is part of a Program Project Grant (PPG) application to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementias (FTD) or frontotemporal lobar degeneration (FTLD). This core supports all data management, statistical, and computing needs, as well as maintains the PPG database for data from patient-oriented studies for all Cores and Projects 1-4 within this PPG. The provided services includes: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures; (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, as well as routine and archival off-site backup of computing systems central to the PPG, including the PPG database; (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, randomization schemes, and performing analyses of PPG data; and (d) development of new statistical methodologies where needed for data analysis. Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in this PPG. The studies proposed in this Core taken together with the complementary studies conducted in the other Cores and all 4 Projects in this PPG will lead to a better understanding of the neurodegenerative mechanisms underiying FTLD with tau pathology and FTLD with TDP-43 pathology which is likely to enhance efforts to develop better diagnostics and therapeutic interventions for these disorders.