Data Management and Statistical Core

数据管理与统计核心 摘要/摘要 这里介绍的数据管理和统计(DMS)核心是加州大学的一个组成部分 宾夕法尼亚医学院(宾夕法尼亚大学)阿尔茨海默病(AD)研究中心(ADRC)。的目标是 DMS在这一应用中的核心是支持数据管理、统计、生物信息学、数据库和 宾夕法尼亚州立大学ADRC调查人员和ADRC发展项目获奖者的相关计算需求。这个 数据管理系统核心提供的服务包括：(A)支持数据表格/调查问卷的设计和开发； 数据库开发和管理、大数据(例如，基因组和成像数据)集成、数据输入、 数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序，(B) 为宾夕法尼亚的所有ADRC活动提供计算和编程支持，包括实施和整合 数据管理和研究、日常工作和异地归档所需的硬件和软件升级 为宾夕法尼亚大学发展研究中心的核心计算系统提供备份；(C)从生物统计学角度支持从 从开始到发表，包括研究设计的发展、执行样本量和力量 (D)向受训人员提供统计培训；(E) 促进宾夕法尼亚大学ADRC和其他由NIA资助的AD研究中心之间的有效工作关系 和国家阿尔茨海默氏症协调中心(NACC)。因此，DMS核心起着重要的和 在宾夕法尼亚大学ADRC中发挥重要作用，这对AD和相关疾病的研究至关重要，受试者为轻度 认知障碍(MCI)和认知正常(CN)对照由宾夕法尼亚ADRC调查人员和 他们在其他区域和区域发展中心的合作者以及继续与 全国反兴奋剂机构。

Data Management and Statistical Core Summary/Abstract The Data Management and Statistical (DMS) Core described here is an integral part of the University of Pennsylvania School of Medicine (Penn) Alzheimer’s Disease (AD) Research Center (ADRC). The goal of the DMS Core in this application is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn ADRC investigators and ADRC Developmental Project awardees. The services provided by the DMS Core include: (a) support for data form/questionnaire design and development, database development and management, big data (e.g., genomic and imaging data) integration, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn ADRC activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Penn ADRC, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the ADRC data, (d) provide statistical training to ADRC trainees, (e) promoting an effective working relationship between the Penn ADRC, other NIA funded AD Research Centers and the National Alzheimer’s Coordinating Center (NACC). Thus, the DMS Core plays an important and significant role in the Penn ADRC that is critical to research on AD and related disorders, subjects with mild cognitive impairment (MCI) and cognitively normal (CN) controls conducted by Penn ADRC investigators and their collaborators at other ADRCs as well as to the continuation of an effective working relationship with NACC.