Biostatistics and Database Core

生物统计学和数据库核心

• 批准号: 10454268
• 负责人: Sharon Xiangwen Xie
• 金额: $ 17.27万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454268
• 关键词: Aging; Archives; Bioinformatics; Biological; Biometry; Cells; Characteristics; Clinical; Collaborations; Complex; Computer Systems; Computer software; Data; Data Analyses; Databases; Development; Frontotemporal Lobar Degenerations; Functional disorder; Generations; Genetic; Genetic Markers; Goals; Grant; Graph; Heterogeneity; Image; Knowledge; Lead; Life; Manuscripts; Medical Genetics; Methodology; Pathologic; Pathology; Pattern; Pennsylvania; Play; Preparation; Procedures; Program Research Project Grants; Publications; Quality Control; Questionnaire Designs; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Role; Sample Size; Security; Services; Site; Statistical Methods; Syndrome; Universities; data management; data quality; frontotemporal degeneration; high dimensionality; insight; medical schools; neuroimaging; neuropathology; novel; open source; operation; protein TDP-43; relational database; single-cell RNA sequencing; statistics; support network; tool; transcriptome; transcriptomics

The Biostatistics and Database Core E is an integral part of this program project grant (PPG) “From cells to complex syndromes: Using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core E is to support the data management, database, statistics, bioinformatics, and related computational needs of the PPG investigators. The services provided by Core E include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the PPG, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the PPG data, (d) support graph theoretic analysis in collaboration with the Neuroimaging Core C, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of the PPG data, Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in the PPG.

生物统计学和数据库核心E是该计划项目资助（PPG）“从细胞到 复杂综合征：利用网络了解TDP相关额颞叶变性的异质性 宾夕法尼亚大学佩雷尔曼医学院（PSOM）的“与衰老”。核心E的目标 是支持数据管理，数据库，统计，生物信息学和相关的计算需求， PPG调查员。核心E提供的服务包括：（a）支持数据表格/问卷设计 数据库开发和管理，数据输入，数据库审计跟踪，数据库安全， 数据库备份和严格的数据质量控制程序，（B）为所有人提供计算和编程支持 PPG活动，包括实施和整合硬件和软件升级， 数据管理和研究，PPG中心计算系统的常规和归档异地备份， (c)为项目和核心的所有研究方面提供从开始到出版的生物统计支持，包括 开发研究设计，进行样本量和把握度计算，并进行 PPG数据，（d）与神经影像核心C合作支持图论分析，（e） 制定新的统计方法，并在需要时推广现有方法， 因此，核心E发挥着重要而显著的作用，对 研究和PPG研究的开展。