Data Management and Statistical Core

数据管理与统计核心

• 批准号: 10264229
• 负责人: Sharon Xiangwen Xie
• 金额: $ 22.96万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264229
• 关键词: Address; Adult; African American; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Amyloid beta-Protein; Archives; Big Data; Bioinformatics; Biological Markers; Biometry; Clinical; Cognitive; Complex; Computer Systems; Computer software; Data; Data Analyses; Data Display; Data Set; Databases; Dementia; Development; Disease; Doctor of Philosophy; Funding; Generations; Genetic; Genetic Markers; Genomics; Goals; Heterogeneity; Image; Lead; Link; Liquid substance; Longitudinal Studies; Manuscripts; Measures; Medical Genetics; Methodology; Methods; National Institute on Aging; Neurodegenerative Disorders; Pathology; Pennsylvania; Phenotype; Play; Preparation; Procedures; Publications; Quality Control; Questionnaire Designs; Reporting; Research; Research Design; Research Personnel; Research Support; Role; Sample Size; Security; Services; Site; Training; Universities; Work; comorbidity; data integration; data management; data quality; data sharing; design; education research; genomic biomarker; heterogenous data; medical schools; mild cognitive impairment; multimodality; neuroimaging; neuropathology; operation; patient oriented; programs; sociodemographic factors; support network; tau Proteins

Data Management and Statistical Core Summary/Abstract The Data Management and Statistical (DMS) Core described here is an integral part of the University of Pennsylvania School of Medicine (Penn) Alzheimer’s Disease (AD) Research Center (ADRC). The goal of the DMS Core in this application is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn ADRC investigators and ADRC Developmental Project awardees. The services provided by the DMS Core include: (a) support for data form/questionnaire design and development, database development and management, big data (e.g., genomic and imaging data) integration, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn ADRC activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Penn ADRC, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the ADRC data, (d) provide statistical training to ADRC trainees, (e) promoting an effective working relationship between the Penn ADRC, other NIA funded AD Research Centers and the National Alzheimer’s Coordinating Center (NACC). Thus, the DMS Core plays an important and significant role in the Penn ADRC that is critical to research on AD and related disorders, subjects with mild cognitive impairment (MCI) and cognitively normal (CN) controls conducted by Penn ADRC investigators and their collaborators at other ADRCs as well as to the continuation of an effective working relationship with NACC.

数据管理和统计核心 总结/摘要 这里描述的数据管理和统计（DMS）核心是大学的一个组成部分， 宾夕法尼亚医学院（Penn）阿尔茨海默病（AD）研究中心（ADRC）。的目标 DMS在这个应用程序中的核心是支持数据管理，统计，生物信息学，数据库， 宾夕法尼亚州ADRC研究人员和ADRC发展项目获奖者的相关计算需求。的 DMS核心提供的服务包括：（a）支持数据表格/调查表的设计和开发， 数据库开发和管理，大数据（例如，基因组和成像数据）集成，数据输入， 数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序，（B） 计算和编程支持所有宾州ADRC活动，包括实施和整合 进行数据管理和研究所需的硬件和软件升级，并进行日常工作和异地存档 宾夕法尼亚州ADRC中心计算机系统的备份，（c）对所有研究方面的生物统计支持， 从开始到发表，包括研究设计的开发、执行样本量和把握度 计算，并执行ADRC数据的分析，（d）为ADRC学员提供统计培训，（e） 促进宾夕法尼亚州ADRC与其他NIA资助的AD研究中心之间的有效工作关系 国家阿尔茨海默氏症协调中心（NACC）因此，DMS核心发挥着重要的作用， 在宾夕法尼亚州ADRC中的重要作用，对AD和相关疾病的研究至关重要，轻度 由Penn ADRC研究者进行的认知障碍（MCI）和认知正常（CN）对照， 他们在其他发展成果中心的合作者，以及继续有效的工作关系， NACC。