Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
基本信息
- 批准号:10371806
- 负责人:
- 金额:$ 10.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AlcoholsAlkenesAlkynesAreaAttentionBiologicalCarbonCarbon DioxideCarboxylic AcidsCatalysisChemistryCommunitiesComplexCouplingDevelopmentGenerationsGoalsGrowthImprove AccessInvestigationKnowledgeLigandsLiteratureMethodsMolecularNatural ProductsNickelNitrogenOrganic SynthesisOxygenPalladiumPharmacologic SubstanceReactionReagentReportingResearchResearch PersonnelStructureSynthesis ChemistrySystemTherapeutic AgentsTitaniumTransition ElementsTranslatingWorkcatalystchemical synthesisdesigndieneexperienceimprovedinnovationinsightinterestnovelprofessorprogramsscaffoldtherapeutic targettitanocenetool
项目摘要
Principle Investigator/Program Director (Last, first, middle): Dong, Vy, M
Project Summary/Abstract:
The synthesis and implementation of organometallic reagents and intermediates has become a
cornerstone in the formation of complex therapeutic agents. Thus, the development of novel methods for
accessing these intermediates in a simple and efficient manner has become a large focus of the synthetic
organic and organometallic community. Organozinc reagents have shown themselves to be a powerful tool in
complex organic synthesis in areas such as carbonyl addition, cross coupling reactions (Negeshi coupling),
and functionalization of alkenes and alkynes. As the need for these important nucleophiles becomes more
apparent, chemists have sought out ways to make them by efficient and sustainable methods. Previous work
by Knochel and Sato has shown that nickel and titanium catalysts can convert olefins to organozincs efficiently,
however their work does not impose stereochemical selectivity. Our goal, described herein, is to expand on the
use of titanium catalysis to generate organozincs in an enantiopure method using chiral titanium catalysts and
simple, unbiased olefins as starting materials. Following the formation of these stereochemically active
nucleophiles, we aim to couple them with carbon dioxide using chemistry similar to previous studies in the
Dong research group. Utilizing simple and readily available starting materials as well as more structurally
diverse catalysts and substrates to gain access to these species could improve access to organozinc
intermediates as well as their use in the synthesis of complex final products.
首席研究员/项目主任(后、一、中):董、维、M
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vy M Dong其他文献
Vy M Dong的其他文献
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{{ truncateString('Vy M Dong', 18)}}的其他基金
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
10005641 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
9788994 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes
化学合成的创新工具:金属氢化物催化、药用基序和分子探针
- 批准号:
10624041 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
10383678 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
10388773 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
10601545 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Innovative Tools for Chemical Synthesis: Cyclase-inspired Catalysis, Shuttle Catalysis , and Tandem Catalysis
化学合成的创新工具:环化酶催化、穿梭催化和串联催化
- 批准号:
10649303 - 财政年份:2018
- 资助金额:
$ 10.16万 - 项目类别:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
催化加氢酰化:将 C-H 键转化为生物相关的酯和酮
- 批准号:
8596746 - 财政年份:2013
- 资助金额:
$ 10.16万 - 项目类别:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
催化加氢酰化:将 C-H 键转化为生物相关的酯和酮
- 批准号:
8689122 - 财政年份:2013
- 资助金额:
$ 10.16万 - 项目类别:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
催化加氢酰化:将 C-H 键转化为生物相关的酯和酮
- 批准号:
8839795 - 财政年份:2013
- 资助金额:
$ 10.16万 - 项目类别:
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