Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis

主要研究者/项目负责人（最后，第一，中间）：Dong，Vy，M 项目概要/摘要： 有机金属试剂和中间体的合成和应用已成为一个 复杂治疗药物形成的基石。因此，开发新的方法， 以简单和有效的方式获得这些中间体已经成为合成的大焦点。 有机和有机金属化合物。有机锌试剂已经显示出它们本身是一种强有力的工具， 在羰基加成、交叉偶联反应（Negeshi偶联）、 以及烯烃和炔烃的官能化。随着对这些重要的亲核试剂的需求越来越大， 显然，化学家们已经找到了通过有效和可持续的方法来制造它们的方法。以前的工作 Knochel和Sato的研究表明镍和钛催化剂可以有效地将烯烃转化为有机锌， 然而，他们的工作并不强加立体化学选择性。我们的目标，在此描述，是扩大对 在使用手性钛催化剂的对映体纯方法中钛催化生成有机锌的用途， 简单的、无偏的烯烃作为起始原料。在这些立体化学活性的形成之后 亲核试剂，我们的目标是用类似于以前研究的化学方法将它们与二氧化碳偶联。 董研究小组。利用简单易得的起始材料， 不同的催化剂和底物，以获得这些物种可以改善获得有机锌 中间体以及它们在合成复杂最终产物中的用途。

Principle Investigator/Program Director (Last, first, middle): Dong, Vy, M   Project Summary/Abstract: The synthesis and implementation of organometallic reagents and intermediates has become a cornerstone in the formation of complex therapeutic agents. Thus, the development of novel methods for accessing these intermediates in a simple and efficient manner has become a large focus of the synthetic organic and organometallic community. Organozinc reagents have shown themselves to be a powerful tool in complex organic synthesis in areas such as carbonyl addition, cross coupling reactions (Negeshi coupling), and functionalization of alkenes and alkynes. As the need for these important nucleophiles becomes more apparent, chemists have sought out ways to make them by efficient and sustainable methods. Previous work by Knochel and Sato has shown that nickel and titanium catalysts can convert olefins to organozincs efficiently, however their work does not impose stereochemical selectivity. Our goal, described herein, is to expand on the use of titanium catalysis to generate organozincs in an enantiopure method using chiral titanium catalysts and simple, unbiased olefins as starting materials. Following the formation of these stereochemically active nucleophiles, we aim to couple them with carbon dioxide using chemistry similar to previous studies in the Dong research group. Utilizing simple and readily available starting materials as well as more structurally diverse catalysts and substrates to gain access to these species could improve access to organozinc intermediates as well as their use in the synthesis of complex final products.