Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto

催化加氢酰化：将 C-H 键转化为生物相关的酯和酮

• 批准号: 8596746
• 负责人: Vy M Dong
• 金额: $ 27.95万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8596746
• 关键词: 3-hydroxybutanal; Aldehydes; Alkenes; Alkynes; Amides; Amination; Antibiotics; Antineoplastic Agents; Biological Factors; Biology; Carbon; Catalysis; Cobalt; Complement; Coupling; Development; Emerging Technologies; Esters; Experimental Designs; Future; Health; Homo; Human; Hydrogen Bonding; Ketones; Knowledge; Lactams; Lactones; Lead; Medicine; Metals; Methods; Molecular Structure; Nickel; Organic Chemistry; Pharmaceutical Chemistry; Pharmacologic Substance; Reaction; Reagent; Research; Rhodium; Ruthenium; Structure; Time; Ursidae Family; Work; carbonyl group; catalyst; design; diene; drug discovery; ferryl iron; functional group; human disease; innovation; insight; novel; programs; public health relevance; scaffold; tool

DESCRIPTION (provided by applicant): The carbonyl group is a structural motif common in a diverse range of natural products and pharmaceutical agents used to treat human diseases. This project involves the systematic expansion of hydroacylation as an ideal and powerful strategy for making carbonyl-containing compounds, including both esters and ketones. This innovative approach will lead to step- and atom-economical, sustainable, and stereoselective methods that greatly bolster our ability to access molecules relevant to human health, including enantiopure heterocycles and polyketides. In addition, these studies will provide efficient ways to make building blocks that can be elaborated to bioactive structures. Besides the practical value, this project will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing challenge in modern organic chemistry.

描述(由申请人提供)：羰基是一种结构基元，在用于治疗人类疾病的各种天然产品和药剂中很常见。该项目涉及系统地扩展氢酰化反应，将其作为制造包括酯和酮在内的含酮化合物的一种理想而有力的策略。这种创新的方法将导致步骤和原子经济的、可持续的和立体选择性的方法，极大地增强我们获得与人类健康相关的分子的能力，包括对映体杂环和聚酮。此外，这些研究将提供有效的方法来制造可以精心制作成生物活性结构的积木。除了实用价值，该项目还将为各种催化剂的使用提供基本的见解，包括Rh、Ru、Co和Ni，用于碳氢键的活化和功能化-这是现代有机化学中的一个长期挑战。