Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis

该研究计划的重点是通过电力解决化学结构和反应性的差距 催化作用。受到金属酶的启发，我的实验室设计，研究和发明了创新的工具， 化学合成克服了对手性助剂和化学计量活化剂的需要。的 所提出的交叉偶联方法的特征在于使用共同的官能团（例如，醛，胺， 炔和烯烃），并生成新的碳-碳和碳-氮键， 经济通过这种方法可以获得广泛的手性基序，并且所获得的见解将 最终增强我们控制化学反应性和构建化学结构的能力。这又 知识大大增强了我们发现治疗人类疾病的新药的能力， 大规模生产这些药品。该计划具有许多新的方向， 令人信服的初步数据，包括环化酶启发的催化，穿梭催化，串联催化。 除了实用价值外，该计划还将为各种催化剂的使用提供基本见解， 包括铑、钌、钴和镍，用于碳-氢的活化和官能化 键-现代有机化学中的一个长期存在的挑战。

This research program focuses on addressing gaps in chemical structure and reactivity through the power of catalysis. Inspired by metalloenzymes, my laboratory designs, studies, and invents innovative tools for chemical synthesis that overcome the need for chiral auxiliaries and stoichiometric activating agents. The cross-coupling methods proposed feature the use of common functional groups (e.g., aldehydes, amines, alkynes, and alkenes) and generate new carbon-carbon and carbon-nitrogen bond with excellent atom economy. A wide range of chiral motifs can be accessed by this approach and the insights gained will ultimately enhance our ability to control chemical reactivity and build chemical structures. In turn, this knowledge greatly augments our ability to discover new medicines for treating human diseases, as well as prepare these medicines on large scale. The program features many new directions supported by compelling preliminary data including cyclase-inspired catalysis, shuttle catalysis, and tandem catalysis. Besides the practical value, this program will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds—a long standing challenge in modern organic chemistry.