Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto

催化加氢酰化：将 C-H 键转化为生物相关的酯和酮

• 批准号: 8689122
• 负责人: Vy M Dong
• 金额: $ 27.94万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689122
• 关键词: 3-hydroxybutanal; Aldehydes; Alkenes; Alkynes; Amides; Amination; Antibiotics; Antineoplastic Agents; Biological Factors; Biology; Carbon; Catalysis; Cobalt; Complement; Coupling; Development; Emerging Technologies; Esters; Experimental Designs; Future; Health; Homo; Human; Hydrogen Bonding; Ketones; Knowledge; Lactams; Lactones; Lead; Medicine; Metals; Methods; Molecular Structure; Nickel; Organic Chemistry; Pharmaceutical Chemistry; Pharmacologic Substance; Reaction; Reagent; Research; Rhodium; Ruthenium; Structure; Time; Ursidae Family; Work; carbonyl group; catalyst; design; diene; drug discovery; ferryl iron; functional group; human disease; innovation; insight; novel; programs; public health relevance; scaffold; tool

DESCRIPTION (provided by applicant): The carbonyl group is a structural motif common in a diverse range of natural products and pharmaceutical agents used to treat human diseases. This project involves the systematic expansion of hydroacylation as an ideal and powerful strategy for making carbonyl-containing compounds, including both esters and ketones. This innovative approach will lead to step- and atom-economical, sustainable, and stereoselective methods that greatly bolster our ability to access molecules relevant to human health, including enantiopure heterocycles and polyketides. In addition, these studies will provide efficient ways to make building blocks that can be elaborated to bioactive structures. Besides the practical value, this project will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing challenge in modern organic chemistry.

描述（由申请人提供）：羰基是用于治疗人类疾病的各种天然产物和药物制剂中常见的结构基序。该项目涉及加氢酰化的系统扩展，作为制备含羰基化合物（包括酯和酮）的理想和强有力的策略。这种创新的方法将导致步骤和原子经济，可持续和立体选择性的方法，大大提高了我们获得与人类健康相关的分子的能力，包括对映体纯杂环化合物和聚酮化合物。此外，这些研究将提供有效的方法，使积木，可以详细说明生物活性结构。除了实用价值外，该项目还将提供使用各种催化剂的基本见解，包括铑，钌，钴和镍，用于活化和官能化碳-氢键-这是现代有机化学中的一个长期挑战。