Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto

描述（由申请人提供）：羰基是用于治疗人类疾病的多种天然产物和药物制剂中常见的结构基序。该项目涉及系统扩展氢化酰基作为一个理想的和强大的策略，以制造含羰基的化合物，包括酯和酮。这种创新的方法将导致步进和原子经济、可持续和立体选择的方法，极大地增强我们获得与人类健康相关的分子的能力，包括对映不纯杂环和聚酮。此外，这些研究将提供有效的方法来制作可以被精心制作成生物活性结构的积木。除了实用价值外，该项目还将为各种催化剂的使用提供基础见解，包括铑、钌、钴和镍，用于碳氢键的激活和功能化——这是现代有机化学中的一个长期挑战。

DESCRIPTION (provided by applicant): The carbonyl group is a structural motif common in a diverse range of natural products and pharmaceutical agents used to treat human diseases. This project involves the systematic expansion of hydroacylation as an ideal and powerful strategy for making carbonyl-containing compounds, including both esters and ketones. This innovative approach will lead to step- and atom-economical, sustainable, and stereoselective methods that greatly bolster our ability to access molecules relevant to human health, including enantiopure heterocycles and polyketides. In addition, these studies will provide efficient ways to make building blocks that can be elaborated to bioactive structures. Besides the practical value, this project will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing challenge in modern organic chemistry.