Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes
Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes
批准号:
10624041
负责人:
Vy M Dong
金额:
$47.49万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-05-01 至 2028-07-31
关键词:
AddressAldehydesAlkenesAlkynesAminesArchitectureBiologyCarbonCatalysisChemicalsCobaltCopperCouplingEnvironmentFriendsMedicineMetalsMethodsMicroscopyModernizationMolecularMolecular ProbesNMR SpectroscopyNatureNitrogenOrganic SynthesisPeriodicityPharmaceutical ChemistryResearch Project SummariesRhodiumScienceStyrenesTheoretical StudiesTherapeuticTrainingTransition Elementscancer immunotherapycatalystchemical synthesiscyclopropenedesigndesign and constructiondienedrug discoveryexperimental studyfunctional groupinnovationinsightinventiontheoriestoolunsaturated bonds
中文摘要
项目摘要
有机合成的研究和培训影响着所有需要设计和建造的科学领域。
分子结构。该项目将推进催化方法,包括加氢酰化和
氢胺化是化学合成中有吸引力且强大的工具。提出的耦合方法有
现代的和创新的,因为它们依赖于共同的官能团(例如,醛、胺)来生成
来自不饱和配偶体的新的碳-碳和碳-氮键(例如,苯乙烯,二烯,
环丙烯),具有高选择性和原子经济性。通过实验和理论研究,
该项目将产生对各种过渡金属催化剂的机理的基本见解,包括铑,
钴和铜。除了催化和机理研究,我们计划建立高分子的化学基序,
对药物发现领域的重要性。我们针对特权图案(例如,手性含氮
杂环)和探索化学空间(例如,具有高SP3特性的三环笼)。通过
与其他领域的专家合作,我们解决了荧光显微镜,核磁共振,
光谱学和通过设计功能分子的癌症免疫疗法。这个项目展示
在催化、药物化学和生物学的界面上制造分子的创新。
英文摘要
Project Summary
Research and training in organic synthesis impacts all fields of science that require the design and construction
of molecular architecture. This project will advance catalytic methods, including hydroacylation and
hydroamination, as attractive and powerful tools for chemical synthesis. The coupling methods proposed are
modern and innovative because they rely on common functional groups (e.g., aldehydes, amines) to generate
new carbon-carbon and carbon-nitrogen bonds from unsaturated partners (e.g., styrenes, dienes,
cyclopropenes), with high selectivity and atom economy. Through experimental and theoretical studies, this
project will yield fundamental insights into the mechanism of various transition metal catalysts, including rhodium,
cobalt, and copper. Beyond catalysis and mechanistic studies, we plan to build chemical motifs of high
significance to the field of drug discovery. We target privileged motifs (e.g., chiral nitrogen-containing
heterocycles) and explore chemical space (e.g., tricyclic cages bearing high sp3 character). Through
partnerships with experts in other fields, we address exciting challenges in fluorescent microscopy, NMR
spectroscopy, and cancer immunotherapy by designing functional molecules. This project demonstrates
innovation in making molecules at the interface of catalysis, medicinal chemistry, and biology.
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DOI:
10.1021/jacs.7b09188
发表时间:
2017-10-11
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Yang XH, Lu A, Dong VM]
通讯作者:
Dong VM
DOI:
10.1021/jacs.2c12779
发表时间:
2023-02-10
期刊:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子:
15
作者:
[Li, Qi, Wang, Zhen, Dong, Vy M., Yang, Xiao-Hui]
通讯作者:
Yang, Xiao-Hui
DOI:
10.1021/jacs.8b06069
发表时间:
2018-08-15
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Wu X, Cruz FA, Lu A, Dong VM]
通讯作者:
Dong VM
DOI:
10.1021/jacs.8b11395
发表时间:
2019-02
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Xiao-Hui Yang;Ryan T Davison;Shao-Zhen Nie;F. Cruz;Tristan M McGinnis;V. Dong]
通讯作者:
Xiao-Hui Yang;Ryan T Davison;Shao-Zhen Nie;F. Cruz;Tristan M McGinnis;V. Dong
DOI:
10.1002/anie.201804955
发表时间:
2018-10-08
期刊:
Angewandte Chemie (International ed. in English)
影响因子:
--
作者:
[Park JW, Kang B, Dong VM]
通讯作者:
Dong VM
共 14 条
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:10005641
-
项目类别:
-
资助金额:$9.12万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:9788994
-
项目类别:
-
资助金额:$3.34万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:10383678
-
项目类别:
-
资助金额:$43.57万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:10388773
-
项目类别:
-
资助金额:$7.05万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:10601545
-
项目类别:
-
资助金额:$0.28万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-inspired Catalysis, Shuttle Catalysis , and Tandem Catalysis
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批准号:10649303
-
项目类别:
-
资助金额:$6.98万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:10371806
-
项目类别:
-
资助金额:$10.16万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
-
批准号:8596746
-
项目类别:
-
资助金额:$27.95万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
-
批准号:8689122
-
项目类别:
-
资助金额:$27.94万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
-
批准号:8839795
-
项目类别:
-
资助金额:$27.87万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and ketones
-
批准号:9505179
-
项目类别:
-
资助金额:$9.26万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and ketones
-
批准号:9094629
-
项目类别:
-
资助金额:$27.78万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
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批准号:6830722
-
项目类别:
-
资助金额:$4.4万
-
财政年份:2003
-
负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
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批准号:7147906
-
项目类别:
-
资助金额:$3.09万
-
财政年份:2003
-
负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
-
批准号:6648966
-
项目类别:
-
资助金额:$3.97万
-
财政年份:2003
-
负责人:Vy M Dong
-
依托单位:
海外基金