Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes
Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes
批准号:
10624041
负责人:
Vy M Dong
金额:
$47.49万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-05-01 至 2028-07-31
关键词:
AddressAldehydesAlkenesAlkynesAminesArchitectureBiologyCarbonCatalysisChemicalsCobaltCopperCouplingEnvironmentFriendsMedicineMetalsMethodsMicroscopyModernizationMolecularMolecular ProbesNMR SpectroscopyNatureNitrogenOrganic SynthesisPeriodicityPharmaceutical ChemistryResearch Project SummariesRhodiumScienceStyrenesTheoretical StudiesTherapeuticTrainingTransition Elementscancer immunotherapycatalystchemical synthesiscyclopropenedesigndesign and constructiondienedrug discoveryexperimental studyfunctional groupinnovationinsightinventiontheoriestoolunsaturated bonds
中文摘要
项目总结
英文摘要
Project Summary
Research and training in organic synthesis impacts all fields of science that require the design and construction
of molecular architecture. This project will advance catalytic methods, including hydroacylation and
hydroamination, as attractive and powerful tools for chemical synthesis. The coupling methods proposed are
modern and innovative because they rely on common functional groups (e.g., aldehydes, amines) to generate
new carbon-carbon and carbon-nitrogen bonds from unsaturated partners (e.g., styrenes, dienes,
cyclopropenes), with high selectivity and atom economy. Through experimental and theoretical studies, this
project will yield fundamental insights into the mechanism of various transition metal catalysts, including rhodium,
cobalt, and copper. Beyond catalysis and mechanistic studies, we plan to build chemical motifs of high
significance to the field of drug discovery. We target privileged motifs (e.g., chiral nitrogen-containing
heterocycles) and explore chemical space (e.g., tricyclic cages bearing high sp3 character). Through
partnerships with experts in other fields, we address exciting challenges in fluorescent microscopy, NMR
spectroscopy, and cancer immunotherapy by designing functional molecules. This project demonstrates
innovation in making molecules at the interface of catalysis, medicinal chemistry, and biology.
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DOI:
10.1021/jacs.7b09188
发表时间:
2017-10-11
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Yang XH, Lu A, Dong VM]
通讯作者:
Dong VM
DOI:
10.1021/jacs.2c12779
发表时间:
2023-02-10
期刊:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子:
15
作者:
[Li, Qi, Wang, Zhen, Dong, Vy M., Yang, Xiao-Hui]
通讯作者:
Yang, Xiao-Hui
DOI:
10.1021/jacs.8b06069
发表时间:
2018-08-15
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Wu X, Cruz FA, Lu A, Dong VM]
通讯作者:
Dong VM
DOI:
10.1021/jacs.8b11395
发表时间:
2019-02
期刊:
Journal of the American Chemical Society
影响因子:
15
作者:
[Xiao-Hui Yang;Ryan T Davison;Shao-Zhen Nie;F. Cruz;Tristan M McGinnis;V. Dong]
通讯作者:
Xiao-Hui Yang;Ryan T Davison;Shao-Zhen Nie;F. Cruz;Tristan M McGinnis;V. Dong
DOI:
10.1002/anie.201804955
发表时间:
2018-10-08
期刊:
Angewandte Chemie (International ed. in English)
影响因子:
--
作者:
[Park JW, Kang B, Dong VM]
通讯作者:
Dong VM
共 14 条
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:10005641
-
项目类别:
-
资助金额:$9.12万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:9788994
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项目类别:
-
资助金额:$3.34万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:10383678
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项目类别:
-
资助金额:$43.57万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
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批准号:10388773
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项目类别:
-
资助金额:$7.05万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:10601545
-
项目类别:
-
资助金额:$0.28万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-inspired Catalysis, Shuttle Catalysis , and Tandem Catalysis
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批准号:10649303
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项目类别:
-
资助金额:$6.98万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis
-
批准号:10371806
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项目类别:
-
资助金额:$10.16万
-
财政年份:2018
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
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批准号:8596746
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项目类别:
-
资助金额:$27.95万
-
财政年份:2013
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负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
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批准号:8689122
-
项目类别:
-
资助金额:$27.94万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
-
批准号:8839795
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项目类别:
-
资助金额:$27.87万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and ketones
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批准号:9505179
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项目类别:
-
资助金额:$9.26万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and ketones
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批准号:9094629
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项目类别:
-
资助金额:$27.78万
-
财政年份:2013
-
负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
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批准号:6830722
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项目类别:
-
资助金额:$4.4万
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财政年份:2003
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负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
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批准号:7147906
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项目类别:
-
资助金额:$3.09万
-
财政年份:2003
-
负责人:Vy M Dong
-
依托单位:
Development of a Novel Imine-yne Metathesis Reaction
-
批准号:6648966
-
项目类别:
-
资助金额:$3.97万
-
财政年份:2003
-
负责人:Vy M Dong
-
依托单位:
海外基金