Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes

化学合成的创新工具：金属氢化物催化、药用基序和分子探针

• 批准号: 10624041
• 负责人: Vy M Dong
• 金额: $ 47.49万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624041
• 关键词: Address; Aldehydes; Alkenes; Alkynes; Amines; Architecture; Biology; Carbon; Catalysis; Chemicals; Cobalt; Copper; Coupling; Environment; Friends; Medicine; Metals; Methods; Microscopy; Modernization; Molecular; Molecular Probes; NMR Spectroscopy; Nature; Nitrogen; Organic Synthesis; Periodicity; Pharmaceutical Chemistry; Research Project Summaries; Rhodium; Science; Styrenes; Theoretical Studies; Therapeutic; Training; Transition Elements; cancer immunotherapy; catalyst; chemical synthesis; cyclopropene; design; design and construction; diene; drug discovery; experimental study; functional group; innovation; insight; invention; theories; tool; unsaturated bonds

Project Summary Research and training in organic synthesis impacts all fields of science that require the design and construction of molecular architecture. This project will advance catalytic methods, including hydroacylation and hydroamination, as attractive and powerful tools for chemical synthesis. The coupling methods proposed are modern and innovative because they rely on common functional groups (e.g., aldehydes, amines) to generate new carbon-carbon and carbon-nitrogen bonds from unsaturated partners (e.g., styrenes, dienes, cyclopropenes), with high selectivity and atom economy. Through experimental and theoretical studies, this project will yield fundamental insights into the mechanism of various transition metal catalysts, including rhodium, cobalt, and copper. Beyond catalysis and mechanistic studies, we plan to build chemical motifs of high significance to the field of drug discovery. We target privileged motifs (e.g., chiral nitrogen-containing heterocycles) and explore chemical space (e.g., tricyclic cages bearing high sp3 character). Through partnerships with experts in other fields, we address exciting challenges in fluorescent microscopy, NMR spectroscopy, and cancer immunotherapy by designing functional molecules. This project demonstrates innovation in making molecules at the interface of catalysis, medicinal chemistry, and biology.

项目摘要 有机合成的研究和培训影响着所有需要设计和建造的科学领域。 分子结构。该项目将推进催化方法，包括加氢酰化和 氢化胺化是化学合成中有吸引力的和强有力的工具。提出的耦合方法有 现代的和创新的，因为它们依赖于共同的官能团（例如，醛、胺）来生成 来自不饱和配偶体的新的碳-碳和碳-氮键（例如，苯乙烯，二烯， 环丙烯），具有高选择性和原子经济性。通过实验和理论研究， 该项目将产生对各种过渡金属催化剂的机理的基本见解，包括铑， 钴和铜。除了催化和机理研究，我们计划建立高分子的化学基序， 对药物发现领域的重要性。我们针对特权图案（例如，手性含氮 杂环）和探索化学空间（例如，具有高SP3特性的三环笼）。通过 与其他领域的专家合作，我们解决了荧光显微镜，核磁共振， 光谱学和通过设计功能分子的癌症免疫疗法。这个项目展示 在催化、药物化学和生物学的界面上制造分子的创新。

项目成果

Intermolecular Hydroamination of 1,3-Dienes To Generate Homoallylic Amines.

• DOI: 10.1021/jacs.7b09188
• 发表时间: 2017-10-11
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Yang XH;Lu A;Dong VM
• 通讯作者: Dong VM

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis.

• DOI: 10.1021/jacs.2c12779
• 发表时间: 2023-02-10
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Li, Qi;Wang, Zhen;Dong, Vy M.;Yang, Xiao-Hui
• 通讯作者: Yang, Xiao-Hui

Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation.

• DOI: 10.1021/jacs.8b06069
• 发表时间: 2018-08-15
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Wu X;Cruz FA;Lu A;Dong VM
• 通讯作者: Dong VM

Catalytic Hydrothiolation: Counterion-Controlled Regioselectivity.

• DOI: 10.1021/jacs.8b11395
• 发表时间: 2019-02
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Xiao-Hui Yang;Ryan T Davison;Shao-Zhen Nie;F. Cruz;Tristan M McGinnis;V. Dong

Catalytic Alkyne Arylation Using Traceless Directing Groups.

• DOI: 10.1002/anie.201804955
• 发表时间: 2018-10-08
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Park JW;Kang B;Dong VM
• 通讯作者: Dong VM