UTMB Clinical and Translational Science Award

UTMB 临床和转化科学奖

• 批准号: 10376310
• 负责人: Randall J Urban
• 金额: $ 428.64万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376310
• 关键词: Address; Affect; African American; Age; Characteristics; Clinic; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Communication; Communities; Country; Course Content; Data; Discipline of Nursing; Diverse Workforce; Education; Educational Curriculum; Effectiveness; Entrepreneurship; Gender; Geriatrics; Goals; Hand; Health; Health Occupations; Health Sciences; Health system; Healthcare Activity; Heterogeneity; Hispanic; Home; Hospitals; Individual; Institutes; Institution; Institutional Review Boards; Leadership; Learning; Longevity; Medical; Methodology; Methods; Minority; Mission; Modeling; Multi-Institutional Clinical Trial; National Center for Advancing Translational Sciences; Native Americans; Outcomes Research; Participant; Patient Care; Patient-Focused Outcomes; Pediatrics; Phase; Population; Pregnancy; Research; Research Activity; Research Personnel; Research Support; Resource Sharing; Resources; Schools; Science; Services; Special Population; Structure; Technology; Testing; Texas; Training; Training and Infrastructure; Translation Process; Translational Research; Universities; Work; analytical tool; base; career; community engagement; comparative effectiveness; data resource; data sharing; design; effective intervention; effectiveness outcome; experience; health goals; improved; informatics infrastructure; informatics training; innovation; inter-institutional; interoperability; knowledge base; medical schools; meetings; multi-site trial; multidisciplinary; novel; operation; patient population; programs; racial and ethnic; science education; skills; translational pipeline

Contact PD/PI: Urban, Randall J. O. Overall Project Summary The University of Texas Medical Branch (UTMB) has participated as a CTSA hub since 2009. The academic home of our CTSA, the Institute for Translational Sciences (ITS), has brought together multidisciplinary translational teams (MTTs) and the resources necessary to accelerate discoveries toward better health for individuals and communities. Building on our existing strengths, CTSA initiatives have transformed UTMB’s learning and research culture to one that embraces multidisciplinary translational team (MTT) approaches to addressing significant health problems. We have developed novel educational curricula, significant clinical research programs in special populations with multisite clinical trials, and provided leadership in the Texas Regional CTSA consortium (TRCC) and nationally. UTMB’s CTSA hub supports the health goals of the nation by generating, testing and disseminating integrative team science, education and best practices through stakeholder involvement at all stages. Managed by a continuous improvement model using an Innovation Scorecard, we will address six specific aims, to: 1) Expand the knowledge base and practice of collaborative teams to advance the conduct of translational research through team-based innovation. Building on our team science leadership, we will test, learn, and disseminate multi-institutional teaming to enhance the quality, efficiency, effectiveness, and diversity of clinical and translational research. 2) Engage local, regional, and national stakeholders to make research more effective at meeting their needs. We will build upon our relationships to extend inter-institutional partnerships, and to work with stakeholders to disseminate scientific findings and advance the field of community engagement. 3) Harness the potential of harmonized large data platforms across the translational spectrum to improve research efficiency, develop technologies to support research teams, and share resources with researchers across the CTSA network. Our aims are designed to enhance our informatics infrastructure and training with regional and CTSA network interoperability putting existing and novel analytics tools into the hands of users. 4) Promote clinical and translational research across the lifespan including special populations. We will expand upon our significant strengths in multi-site trials in special populations to proactively engage the NCATS Trial Innovation Network for new trials originating from UTMB. 5) Improve training for a diverse workforce in the authentic skills needed to advance all phases of clinical and translational research. Our integrated U, K, and T programs will include participants with diverse professional and educational experience, as well as diverse age, gender, racial, and ethnic characteristics. 6) Develop and disseminate improved methods and processes for translation from discovery to improved health. We will apply a continuous improvement approach to understand barriers, develop effective interventions, and disseminate improvements in translational science and operations. Page 430 Project Summary/Abstract Contact PD/PI: Urban, Randall J. Narrative UTMB’s CTSA Hub will work with local, regional, and national partners to support translational research and accelerate discoveries toward better health. We will train a diverse workforce and build multidisciplinary teams to conduct efficient, high-quality clinical research across the lifespan that includes understudied populations. We will integrate our research and healthcare activities and will generate, apply and share data and best practices across institutions. Page 431

联系PD/PI：Urban，Randall J. O.整体而言 项目摘要 德克萨斯大学医学部(UTMB)自2009年以来一直作为CTSA中心参加。学术之家 在我们的CTSA中，翻译科学研究所(ITS)将多学科的翻译 团队(MTT)和必要的资源，以加速发现更好的个人和 社区。在我们现有优势的基础上，CTSA倡议改变了UTMB的学习和研究 文化转变为采用多学科翻译团队(MTT)方法来解决重大问题 健康问题。我们开发了新的教育课程，重要的临床研究项目 拥有多点临床试验的特殊人群，并在德克萨斯地区CTSA财团中发挥领导作用 (TRCC)和全国范围内。UTMB的CTSA中心通过生成、测试和 通过利益相关者的参与传播整合的团队科学、教育和最佳实践 各阶段。通过使用创新记分卡的持续改进模式进行管理，我们将解决六个问题 具体目标：1)扩展协作团队的知识库和实践，以推进实施 通过基于团队的创新实现转化性研究。在我们团队科学领导地位的基础上，我们将测试， 学习和传播多机构合作，以提高质量、效率、效力和多样性 临床和转化性研究。2)让地方、地区和国家利益攸关方参与更多研究 有效地满足他们的需求。我们将在我们关系的基础上，扩大机构间的伙伴关系，并 与利益攸关方合作，传播科学发现，推进社区参与领域。3) 利用跨翻译领域的统一大数据平台的潜力来改进研究 提高效率，开发支持研究团队的技术，并与全球各地的研究人员共享资源 CTSA网络。我们的目标是加强我们的信息基础设施和培训，与地区和 CTSA网络互操作性将现有的和新的分析工具交到用户手中。4)推广 包括特殊人群在内的整个生命周期的临床和转化性研究。我们将扩展我们的 在特殊人群中进行多点试验的显著优势，以积极参与NCATS试验创新 来自UTMB的新试验网络。5)改进对不同劳动力的正宗技能培训 需要推进临床和转化研究的所有阶段。我们集成的U、K和T计划将 包括具有不同专业和教育经验以及不同年龄、性别、种族、 和民族特色。6)制定和传播改进的方法和流程，以便从 从发现到改善健康。我们将应用持续改进的方法来了解障碍，开发 有效的干预措施，并传播翻译科学和业务方面的改进。 第430页 项目摘要/摘要 联系PD/PI：Urban，Randall J. 叙述性 UTMB的CTSA中心将与当地、地区和国家合作伙伴合作，支持翻译研究和 加速发现更好的健康。我们将培训多元化的劳动力队伍，建立多学科团队 在包括未被研究人群在内的整个生命周期内进行高效、高质量的临床研究。 我们将整合我们的研究和医疗保健活动，并将生成、应用和共享数据和最佳 各机构之间的做法。 第431页